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Interpretable machine learning of clinical MALDI-TOF spectra discriminates carbapenem-resistant Klebsiella pneumoniae while revealing phylogenetic heterogeneity that limits model generalizability

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Introduction: Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant public health threat. Rapid detection of CRKP and its resistance mechanisms is essential for optimizing antibiotic therapy and infection control.... ...