Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny [0.03%]
五种高风险人乳头瘤病毒类型的整合频率和APOBEC3谱型符合进化树原则
Alexander Hesselberg Løvestad,Adina Repesa,Jean-Marc Costanzi et al.
Alexander Hesselberg Løvestad et al.
Persistent infection with Human Papillomavirus (HPV) is responsible for almost all cases of cervical cancers, and HPV16 and HPV18 associated with the majority of these. These types differ in the proportion of viral minor nucleotide variants...
Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma [0.03%]
合并靶向磷脂酰肌醇3-激酶/哺乳动物雷帕霉素靶蛋白和丝裂原活化蛋白激酶/细胞外信号调节激酶通路治疗默克尔细胞癌
Arturo Temblador,Dimitrios Topalis,Graciela Andrei et al.
Arturo Temblador et al.
Merkel cell carcinoma (MCC) is an aggressive type of skin cancer, which is caused either by integration of the oncogenic Merkel cell polyomavirus (MCPyV) or by accumulation of UV-light induced mutations. Since the response to immune-checkpo...
The oncogenic gamma herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) hijack retinoic acid-inducible gene I (RIG-I) facilitating both viral and tumour immune evasion [0.03%]
Epstein-Barr病毒（EBV）和卡波西肉瘤疱疹病毒（KSHV）劫持视黄酸诱导基因I（RIG-I），从而促进病毒和肿瘤免疫逃逸
Alana Nash,Elizabeth J Ryan
Alana Nash
Herpesviruses evade host immunity to establish persistent lifelong infection with dormant latent and replicative lytic phases. Epstein-Barr virus (EBV) and Kaposi's Sarcoma-associated virus (KSHV) are double-stranded DNA herpesviruses that ...
HPV and head and neck cancers: Towards early diagnosis and prevention [0.03%]
人乳头状瘤病毒与头部和颈部癌症：走向早期诊断与预防
Luisa Galati,Susanna Chiocca,Daria Duca et al.
Luisa Galati et al.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with an increasing trend of its incidence. Alcohol consumption, smoking, and viral infections, such as the mucosal high-risk (HR) human papillomaviruses...
Detection of high-risk HPV in FFPE specimens of various tumours using the BD Onclarity™ HPV Assay [0.03%]
用于固定福尔马林衍生石蜡包埋肿瘤样本的高危型HPV检测的BD OnclarityTM HPV检测试剂盒
Robert van der Geize,Natalie Methorst,Maarten Niemantsverdriet
Robert van der Geize
Analysis of high-risk HPV status on formalin-fixed paraffin-embedded (FFPE) tissue material is valuable for cervical-, head and neck-, anogenital- and other types of cancer, but commercial HPV assays have been developed specifically for cer...
Women with a positive high-risk human papillomavirus (HPV) test remain at increased risk of HPV infection and cervical precancer ≥15 years later [0.03%]
高危人乳头瘤病毒（HPV）初筛阳性的妇女在随后的15年里仍然面临较高的HPV感染和宫颈癌前病变风险
Federica Inturrisi,Johannes A Bogaards,Albert G Siebers et al.
Federica Inturrisi et al.
Little is known about the long-term association between high-risk human papillomavirus (hrHPV) test results in women participating in a hrHPV-based cervical cancer screening program. To address this question, we collected data of 2217 women...
Small DNA tumor viruses and human cancer: Preclinical models of virus infection and disease [0.03%]
小DNA肿瘤病毒与人类癌症：病毒感染与疾病的临床前模型
Megan E Spurgeon
Megan E Spurgeon
Human tumor viruses cause various human cancers that account for at least 15% of the global cancer burden. Among the currently identified human tumor viruses, two are small DNA tumor viruses: human papillomaviruses (HPVs) and Merkel cell po...
Human papillomavirus seroprevalence and seroconversion following baseline detection of nine human papillomavirus types in young women [0.03%]
年轻女性基线检测出九种人乳头瘤病毒后的人乳头瘤病毒血清流行率和血清转换率
Darron R Brown,Xavier Castellsagué,Daron Ferris et al.
Darron R Brown et al.
Background: Estimates of the humoral immune response to incident human papillomavirus (HPV) infections are limited. Methods: In this po...
Clinical Trial
Tumour virus research. 2022 Jun:13:200236. DOI:10.1016/j.tvr.2022.200236 2022
Carly A Burmeister,Saif F Khan,Georgia Schäfer et al.
Carly A Burmeister et al.
Cervical cancer is the fourth most common female cancer worldwide and results in over 300 000 deaths globally. The causative agent of cervical cancer is persistent infection with high-risk subtypes of the human papillomavirus and the E5, E6...
Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults [0.03%]
HIV阳性和HIV阴性成人中口腔人乳头瘤病毒的流行率、持续感染及危险因素
James Riddell th,Andrew F Brouwer,Heather M Walline et al.
James Riddell th et al.
Background: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls. ...