HTLV-1 HBZ inhibits DHX9 to reprogram circRNA biogenesis in ATLL [0.03%]
人类T细胞白血病病毒I型HBZ通过抑制DHX9重新编程环状RNA的生成在ATLL中的作用
Julien Ladet,Mateo Bazire,Nicolas Fontrodona et al.
Julien Ladet et al.
Human T-cell Leukemia Virus type 1 (HTLV-1) drives Adult T-cell Leukemia/Lymphoma (ATLL) through sustained expression of the viral oncoprotein HBZ. Although HBZ is known to reshape host transcriptional programs, its role in post-transcripti...
HPV8-E6 drives coordinated transcriptional and epigenetic reprogramming of keratinocytes [0.03%]
HPV8-E6通过协调转录和表观遗传重编程驱动角质形成细胞的转化
Martin Hufbauer,Adnan Syed,Felix Bormann et al.
Martin Hufbauer et al.
Beta human papillomaviruses (betaHPVs) act as cofactors in keratinocyte carcinogenesis, but how they reprogram host gene regulation remains unclear. Here, we combined transcriptomic, small RNA and epigenomic profiling to dissect the impact ...
Targeting EBV-associated gastric cancer by lytic induction therapy with nanatinostat [0.03%]
纳米丁那斯他特诱导溶解疗法针对EB病毒相关的胃癌
Man Wu,Shin Yee Hui,Andrew Skora et al.
Man Wu et al.
Latent Epstein-Barr virus (EBV) infection is associated with multiple lymphoid and epithelial cancers in humans. Targeting EBV through lytic induction therapy represents a potential strategy for treating virus-associated malignancies, such ...
Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells [0.03%]
肿瘤溶解病毒劫持GOT1和嘧啶体以促进肿瘤细胞中的嘧啶合成及复制
Ning Tang,Yabin Gong,Changrun Zhao et al.
Ning Tang et al.
Oncolytic viruses selectively infect and kill tumor cells, but the metabolic adaptations that support their replication remain incompletely understood. Here, using oncolytic Newcastle disease virus (NDV) as a model, we identify glutamic-oxa...
Susceptibility of naturally human papillomavirus type 16 major capsid protein L1 variants to vaccines and predictions of future evolutionary trends [0.03%]
人乳头瘤病毒16型重大衣壳蛋白L1天然变异体对疫苗的易感性及其未来进化趋势预测
Dongbo Yu,Jiao Wang,Ying Li et al.
Dongbo Yu et al.
Human papillomavirus type 16 (HPV16) causes over 50% of HPV-related cervical cancers. With the widespread use of virus-like particle (VLP)-based HPV prophylactic vaccines, investigating the differences in viral assembly, infectivity and ant...
PRMT5-mediated symmetric dimethylation of SHBs at Arg169 stabilizes SHBs and promotes angiogenesis and tumor growth [0.03%]
PRMT5介导的SHB蛋白精氨酸169位对称二甲基化稳定SHB并促进血管生成和肿瘤生长
Shuxiang Wu,Xiaozhen Chen,Yilin Huang et al.
Shuxiang Wu et al.
The small hepatitis B surface antigen (SHBs), an oncogenic protein encoded by hepatitis B virus (HBV), contributes to hepatocellular carcinoma. However, the post-translational regulatory mechanisms of SHBs remain incompletely defined. Here,...
30-hydroxygambogic acid activates overlapping and independent apoptotic pathways in HPV positive and HPV negative oral cancer cells [0.03%]
30-羟基藤黄酸激活HPV阳性和HPV阴性口腔癌细胞中的重叠和独立的凋亡途径
Danelle Grubbs,Sonia Wang,Valeria Rodarte et al.
Danelle Grubbs et al.
The global incidence of Head and Neck (HN) cancer has dramatically increased over the past few decades, primarily due to an increasing incidence of HPV infection. HPV infection desensitizes cells to apoptosis through the E6-enabled accelera...
HPV18E6 and CDK5 virus-host interaction is a prospective therapeutic target for HPV-positive cervical cancer [0.03%]
人乳头瘤病毒阳性宫颈癌的治疗靶点HPV18E6和CDK5病毒宿主相互作用
Chuanyun Xiao,Lixin Wang,Chichao Xia et al.
Chuanyun Xiao et al.
The E6 oncoprotein encoded by the cancer-causing human papillomavirus (HPV) is vital for maintaining the ability of the virus to promote cell proliferation and cancer progression. This study identified that cyclin-dependent kinase 5 (CDK5) ...
Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2/M arrest [0.03%]
腺病毒Ad-VT通过cAMP依赖的AMPK-Raptor活化和G2 / M停滞抑制膀胱癌
Dapeng Li,Jing Lu,Ran Zhu et al.
Dapeng Li et al.
Bladder cancer remains a leading cause of cancer-related mortality with limited therapeutic options. This study investigates the antitumor efficacy and mechanism of Ad-VT, a dual-specific oncolytic adenovirus expressing apoptin under the hT...
Hepatitis B viral DNA integration occurs within three days of infection and is enhanced by ATR inhibition [0.03%]
乙型肝炎病毒DNA在感染后三天内整合入宿主基因组，并可被ATR抑制增强
Dong Li,Jochen M Wettengel,Harout Ajoyan et al.
Dong Li et al.
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma, with viral DNA integration into the host genome playing a pivotal role in oncogenesis. While HBV integration has been historically considered an ...