Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma
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Merkel cell carcinoma (MCC) is an aggressive type of skin cancer, which is caused either by integration of the oncogenic Merkel cell polyomavirus (MCPyV) or by accumulation of UV-light induced mutations. Since the response to immune-checkpoint inhibitors is li... ...