Long-term outcomes of anti-CD19 CAR T cell therapy in refractory myasthenia gravis: A case series [0.03%]
抗CD19 CAR-T细胞治疗难治性重症肌无力的长期疗效：一系列病例报告
Tobias Hegelmaier,Jeremias Motte,Denise Walther et al.
Tobias Hegelmaier et al.
Anti-CD19 CAR T cell therapy represents an emerging therapeutic approach for generalized, treatment-refractory myasthenia gravis (MG), a predominantly B-cell-mediated autoimmune disease for which durable treatment-free remission remains an ...
PARP inhibition enhances the antitumor activity of HER3-DXd in non-small cell lung cancer [0.03%]
PARP抑制能增强HER3-DXd在非小细胞肺癌中的抗肿瘤作用
Linh Lin,Narges Moradi,Iris A Lähdeniemi et al.
Linh Lin et al.
Lung cancer, a leading cause of cancer-related mortality, is often driven by mutations in the key oncogenes epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma virus (KRAS). Despite advancements of targeted therapies such as tyr...
Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease [0.03%]
皮层到苍白球的β振荡异常是帕金森病的网络病理生理学基础
Jeong Woo Choi,Amirreza Alijanpourotaghsara,Koorosh Mirpour et al.
Jeong Woo Choi et al.
Parkinson's disease (PD) motor symptoms are linked to excessive beta band (13-35 Hz) oscillations and basal ganglia-cortical (BGC) synchrony, yet their dynamic inter-relation remains unclear. Based on computational modeling, we hypothesize ...
Faecalibacterium prausnitzii-derived L-arginine ameliorates insomnia by inhibiting POMC-ACTH-cortisol axis [0.03%]
粪便杆菌源精氨酸通过抑制POMC-ACTH-皮质醇轴改善失眠症状
Yun Wang,Suyi Xie,Chenyu Li et al.
Yun Wang et al.
Insomnia is associated with gut microbial dysbiosis, but the specific microbial metabolites mediating gut-brain communication remain elusive. Here, we integrate metagenomic sequencing from 171 individuals (primary insomnia, post-COVID insom...
Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors [0.03%]
规模化制备造血干细胞工程改造即用型单靶点细胞毒T细胞治疗实体瘤研究
Yichen Zhu,Jiaji Yu,Yu Jeong Kim et al.
Yichen Zhu et al.
Adoptive T cell therapy for solid tumors is limited by autologous manufacturing complexity and, in allogeneic settings, risks including graft-versus-host disease (GvHD), HLA restriction, and donor variability. We develop a scalable, feeder-...
CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo [0.03%]
CDK8/19抑制可防止对CDK4/6抑制剂的适应性抗药性现象：体内外研究结果
Zachary T Mack,Margarita Yastrebova,Chang-Uk Lim et al.
Zachary T Mack et al.
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have become a standard of care for estrogen receptor-positive breast cancer and are being developed for other malignancies. However, resistance to these drugs readily develops, limiting their ...
Humoral pregnancy analyses reveal strategies for fetal protection and aberrancy in miscarriage [0.03%]
体液妊娠分析揭示了胎儿保护策略和流产异常现象
Brandon M Sie,Yumei Leng,Nadege Nziza et al.
Brandon M Sie et al.
The maternal immune system must simultaneously defend against pathogens with tolerance of the antigenically distinct fetus. Despite the central importance of immune modulation during pregnancy, epitope-level analyses of the maternal antibod...
The evolution of iPSC-based cell therapy across autologous and allogeneic pathways [0.03%]
基于iPSC的细胞治疗在自体和同种异体路径上的演变方向
Anmin Wang,Yunpei Zhang,Hongkui Deng et al.
Anmin Wang et al.
Induced pluripotent stem cell (iPSC)-based treatments have revolutionized regenerative medicine, yielding patient-specific renewable cells without raising ethical concerns related to the use of embryonic stem cells. In two decades, iPSC the...
Targeting of tripartite neuron-cancer-immune cell crosstalk augments response to chemotherapy and immunotherapy [0.03%]
靶向三重神经元-癌症-免疫细胞互作增强化疗和免疫疗法的疗效
Dolly Jain,Nishant Pandey,Somesh K Jha et al.
Dolly Jain et al.
We report presence of cholinergic nerve fibers in the periphery and stroma of colon cancer tissues and their correlation with poor T cell and increased macrophage infiltration. We employed hydrogel-mediated localized delivery of an FDA-appr...
Prevention of myopia in a near-primate by supplemental indigo light suggests a hypothesis for the myopia boom [0.03%]
补充靛蓝光预防近距灵长类动物近视表明一种关于近视激增的假说
Rafael Grytz,Mustapha El Hamdaoui,Takahiro Yamashita et al.
Rafael Grytz et al.
Today, about 2.8 billion people worldwide suffer from myopia (nearsightedness), and projections place the 2050 burden at 4.8 billion people (the "myopia boom"). Myopia results from abnormal elongation of the eye, which causes images to focu...