IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration [0.03%]
Brigitte L Arduini,Timothy A Blenkinsop,Michael Naimark et al.
Brigitte L Arduini et al.
Dry age-related macular degeneration (AMD) is a prevalent blinding disorder characterized by loss of retinal pigment epithelium (RPE) cells and resulting central vision impairment. Here, we describe preclinical studies supporting an investi...
Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis [0.03%]
Oscar Wong,Zhijie Zheng,Mingbang Wang et al.
Oscar Wong et al.
Autism spectrum disorder (ASD) is a heterogeneous condition that lacks objective diagnostic biomarkers, often resulting in delayed intervention. Evidence increasingly links gut microbiota dysregulation to ASD pathophysiology via the microbi...
T cell-engaging bispecific antibodies for myeloid malignancies: Targets, formats, and clinical challenges [0.03%]
Sophie Paczesny,Sonali P Barwe,Anilkumar Gopalakrishnapillai et al.
Sophie Paczesny et al.
T cell-engaging bispecific antibodies (T-BsAbs) have revolutionized immunotherapy for hematologic malignancies, showing promise in lymphoid cancers and myeloma. However, their application in myeloid malignancies like acute myeloid leukemia ...
Hao Ling,Shihua Yang,Xianbao Shi et al.
Hao Ling et al.
Oncolytic viruses (OVs) represent a promising cancer therapy due to their selective cytotoxicity, yet clinical success in lung cancer is hindered by biological barriers and immunosuppressive microenvironments. To address these barriers, an ...
Jonathan H Sussman,Derek A Oldridge,Wenbao Yu et al.
Jonathan H Sussman et al.
Pediatric high-grade glioma (pHGG) is an incurable central nervous system malignancy that is a leading cause of pediatric cancer death. While pHGG shares many similarities with adult glioma, it comprises distinct disease entities. In this s...
Macrophage-mimetic photothermal nanotherapeutics regulate mitochondrial homeostasis and inflammatory cascades in lung ischemia-reperfusion injury [0.03%]
Haoxiang Yuan,Bo Zeng,Pu Shen et al.
Haoxiang Yuan et al.
Pulmonary ischemia-reperfusion injury is a major cause of acute lung injury and primary graft dysfunction after lung transplantation, with few effective treatments available. In this study, we develop a macrophage-membrane-coated mesoporous...
Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians [0.03%]
Fu-Hui Xiao,Hao-Tian Wang,Long Zhao et al.
Fu-Hui Xiao et al.
A youthful molecular profile reflects attenuated aging and preserved health in advanced age. Long-lived individuals (LLIs) show youthful patterns in DNA methylation and gut microbiota, yet their transcriptional trajectories remain underchar...
Omid Hajihassani,Asael Roichman,Jacob A Boyer et al.
Omid Hajihassani et al.
Pancreatic cancer is the third leading cause of cancer-related death in the United States. Current chemotherapy options provide limited benefits. Emerging evidence suggests that a ketogenic diet (KD) exerts anti-tumor effects by reprogrammi...
Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer [0.03%]
Meiheng Sun,Hang Luo,Shuangying Qiao et al.
Meiheng Sun et al.
Triple-negative breast cancer (TNBC) urgently requires promising therapeutic targets. This study identifies sclerostin, an osteocyte-derived secretory protein traditionally linked to bone homeostasis, as an unexpected intracellular oncogeni...
Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling [0.03%]
Jie Liu,Mei Li,Jianming Huang et al.
Jie Liu et al.
Targeted therapy for advanced colorectal cancer (CRC) remains a significant unmet clinical need. Here, we investigate the mechanism of the anti-TROP2 antibody-drug conjugate IMMU132, delivering SN-38 to induce TOP1-mediated DNA damage and c...