Pan-cancer spatial characterization of key immune biomarkers in the tumor microenvironment [0.03%]
肿瘤微环境关键免疫标志物的泛癌种空间表征
James R Lindsay,Jennifer Altreuter,Joao V Alessi et al.
James R Lindsay et al.
Deciphering the composition and spatial organization of the tumor immune microenvironment (TIME) is key to understanding cancer progression and treatment response. Spatial biology techniques such as multiplex immunofluorescence (mIF) offer ...
Dendritic cell immunotherapy advances for solid tumors: Vaccination and modulation [0.03%]
实体瘤的树突状细胞免疫治疗进展：疫苗和调节
Georgia Clayton,Elisa C Toffoli,Tanja D de Gruijl et al.
Georgia Clayton et al.
Dendritic cells (DCs) are potent antigen-presenting cells, key for inducing anti-tumoral immune responses in the tumor microenvironment (TME) and tumor-draining lymph nodes. Within the TME, immunosuppressive signals often render DCs dysfunc...
Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens [0.03%]
金黄色葡萄球菌特异性IgG向IgM的同种型转换扩大了对其他病原菌的反应性
Remy M Muts,Astrid Hendriks,Josefien W Hommes et al.
Remy M Muts et al.
Therapeutic antibodies are actively explored as alternative to treat or prevent bacterial infections. However, the narrow antigen specificity of IgG in combination with broad diversity in bacterial surface structures currently hampers the d...
Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties [0.03%]
具有肿瘤趋向性突变的优化 arena病毒通过持续的免疫调节作用促进安全的抗肿瘤效果
Philipp A Lang,Lisa Holnsteiner,Yara M Machlah et al.
Philipp A Lang et al.
The non-cytopathic arenavirus lymphocytic choriomeningitis virus (LCMV) induces strong anti-tumor responses. To generate an optimized arenavirus for tumor therapy, we passage LCMV in human or murine tumor cells. Occurring mutations shift th...
Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment [0.03%]
解析肿瘤异质性：基于空间信息的肿瘤微环境泛癌分析
Francesca Lodi,Sam Vanmassenhove,Duojiao Chen et al.
Francesca Lodi et al.
Pan-cancer single-cell atlases explore the heterogeneity of cell types residing within the tumor microenvironment (TME). So far, atlases focused on individual cell types, failing to capture the full complexity of the TME. Here, we present a...
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors [0.03%]
体外转录的环状circILNb介导局部递送IL-15和抗PD-L1纳米抗体以激发冷肿瘤的抗肿瘤免疫反应
Dun Niu,Xiaozhuang Ma,Junshi Zhu et al.
Dun Niu et al.
The clinical translation of combined immunocytokine (IC) and immune checkpoint inhibitor (ICI) is constrained by relapse of advanced malignancies, systemic toxicities, and prohibitive research and synthesis costs. In this study, the circCV-...
Food- vs. supplement-based very-low-energy diets and gut microbiome composition in women with high body mass index: A randomized controlled trial [0.03%]
高体重指数女性中以食物为基础与以补充剂为基础的极低能量膳食对肠道微生物组成的影响：一项随机对照试验
Melissa M Lane,Amelia J McGuinness,Mohammadreza Mohebbi et al.
Melissa M Lane et al.
In a single-blind, two-arm, randomized controlled-feeding trial (May 2021-February 2022), 47 women (30-65 years, BMI 30-45 kg/m2) are randomized to either a food-based or a supplement-based very-low-energy diet (VLED: 800-900 kcal/d) for 3 ...
Griffin I Kane,Tiana E Naylor,Ellis F Lusi et al.
Griffin I Kane et al.
We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvan...
A nanobody-based tri-specific NK cell engager targeting CD5 triggers antitumor immunity [0.03%]
一种基于纳米抗体的三特异性NK细胞ENGAGER，可靶向CD5并激发抗肿瘤免疫响应
Chen Yang,Ping Wang,Mingjun Yang et al.
Chen Yang et al.
The poor prognosis of patients with recurrent or refractory T cell malignancies emphasizes the need for improved immunotherapies. CD5 is a characteristic marker of malignant T cells and is expressed on almost all normal T cells. Therefore, ...
Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma [0.03%]
肠梭杆菌衍生的丙酸抑制透明细胞肾细胞癌的发展
Jun-Yao Xu,Huan Chen,Yao-Yu Yu et al.
Jun-Yao Xu et al.
Gut microbiota has been reported to be associated with the development of various diseases; however, its interaction with clear cell renal cell carcinoma (ccRCC) remains unknown. To investigate the potential relationship between gut microbi...