Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer [0.03%]
肝转移抑制结直肠癌中IL18驱动的γδT细胞活性和免疫治疗反应性
Allard W J van Renterghem,Miguel Parra-Martinez,Maartje Witsen et al.
Allard W J van Renterghem et al.
Patients with liver metastases (LMs) derive less benefit from immune checkpoint blockade (ICB), yet the mechanism remains poorly understood. In the liver tumor microenvironment of patients with mismatch repair-deficient (MMR-d) cancers trea...
An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk [0.03%]
胎盘血代谢组百科揭示母胎互作及疾病风险
Samuel Lancaster,Samson Mataraso,Jonathan D Reiss et al.
Samuel Lancaster et al.
Metabolites present in the mother traverse the placenta to supply energy, essential nutrients, and communication signals to the fetus. To gain a deeper understanding of fetal metabolism and the impacts of maternal metabolic health and medic...
Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target [0.03%]
泛癌N-糖蛋白组谱图揭示FAT2为可操作的表面靶点
Meinusha Govindarajan,Salvador Mejia-Guerrero,Shawn C Chafe et al.
Meinusha Govindarajan et al.
Cell surface proteins offer significant cancer therapeutic potential attributable to their accessible membrane localization and central roles in cellular signaling, yet their promise remains largely untapped due to technical challenges inhe...
Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers [0.03%]
系统性孤儿RNA注释揭示了可被血液获取的肿瘤身份及新发生的致癌驱动基因分子条形码
Jeffrey Wang,Jung Min Suh,Brian J Woo et al.
Jeffrey Wang et al.
From extrachromosomal DNA to neo-peptides, reprogramming of cancer genomes leads to the emergence of cancer state-specific molecules. Here, we systematically identify and characterize a large repertoire of orphan non-coding RNAs (oncRNAs), ...
CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL [0.03%]
CAR-T细胞的CD38-CD73-Tim-3-HLA-DR+表型可以预测其作为B细胞前体急性淋巴细胞白血病治疗药物tisagenlecleucel疗效的潜能
Takashi Mikami,Itaru Kato,Mara Anais Llamas-Covarrubias et al.
Takashi Mikami et al.
Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy is highly effective for B cell precursor acute lymphoblastic leukemia (BCP-ALL); however, approximately half of the patients relapse. Thus, there is an urgent need to identify facto...
Sayali Onkar,Cansu Cimen Bozkus,Mansi Saxena et al.
Sayali Onkar et al.
Over the past decade, clinical trials of therapeutic cancer vaccines have evolved substantially in scope and design, renewing interest in this immunotherapy modality. Advances in sequencing technologies and an improved understanding of the ...
Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions [0.03%]
肠道微生物组和肥胖症治疗：饮食、手术和药物干预之间的桥梁
Davide Masi,Mikiko Watanabe,Karine Clément
Davide Masi
In the mid-2000s, mouse studies suggested that the gut microbiome might influence energy harvest, fat storage, appetite, insulin sensitivity, and inflammation. Since then, our understanding of the gut microbiome's role in obesity has advanc...
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity [0.03%]
微针递送CAR-M样工程化巨噬细胞通过增强吞噬作用缓解椎间盘退行性病变
Xingyu Zhou,Dingchao Zhu,Di Wu et al.
Xingyu Zhou et al.
Published Erratum
Cell reports. Medicine. 2026 Jan 22:102620. DOI:10.1016/j.xcrm.2026.102620 2026
Quin Yuhui Xie,Jill K Hamilton,Jayne S Danska
Quin Yuhui Xie
The rapidly increasing global incidence of youth-onset diabetes is a critical public health concern. Earlier type 2 diabetes (T2D) onset in children and young people is characterized by faster progression and higher risk for complications. ...
Design of a bispecific peptide-nanozyme conjugate for cancer immunotherapy [0.03%]
一种用于癌症免疫治疗的双特异性肽-纳米酶缀合物的设计
Danhong Chen,Ran Xu,Xiaoyun Ye et al.
Danhong Chen et al.
Despite advances in cancer immunotherapy, clinical efficacy remains constrained by immunosuppressive tumor microenvironment (TME), including PD-L1-mediated T cell dysfunction and CXCL8-driven myeloid cell recruitment. To address this, a bis...