Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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The non-cytopathic arenavirus lymphocytic choriomeningitis virus (LCMV) induces strong anti-tumor responses. To generate an optimized arenavirus for tumor therapy, we passage LCMV in human or murine tumor cells. Occurring mutations shift the virus tropism towa... ...
