GABAB receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro [0.03%]
拮抗剂4-氨基吡啶短暂诱导GABA_B受体外向电流的离体研究
Adriano Cattani,Siyan Wang,Maxime Lévesque et al.
Adriano Cattani et al.
The K+ channel blocker 4-aminopyridine (4AP) has been extensively used to investigate the mechanisms underlying neuronal network synchronization in both in vitro and in vivo animal models of focal epilepsy. 4AP-induced effects are parallele...
Shahriar SheikhBahaei,Marissa Millwater,Gerald A Maguire
Shahriar SheikhBahaei
Childhood-onset fluency disorder, commonly referred to as stuttering, affects over 70 million adults worldwide. While stuttering predominantly initiates during childhood and is more prevalent in males, it presents consistent symptoms during...
Serotonergic mediation of the brain-wide neurogenesis: Region-dependent and receptor-type specific roles on neurogenic cellular transformation [0.03%]
五羟色胺介导的脑内神经发生：区域依赖性和受体类型特异性神经发生细胞转化作用
Yuki Higuchi,Hiroyuki Arakawa
Yuki Higuchi
Brain serotonin (5-hydroxytryptamine, 5-HT) is a key molecule for the mediation of depression-related brain states, but the neural mechanisms underlying 5-HT mediation need further investigation. A possible mechanism of the therapeutic anti...
Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques [0.03%]
杏仁体-前额叶回路中的多重通讯途径：人和恒河猴的比较研究
C Giacometti,C Amiez,F Hadj-Bouziane
C Giacometti
The network formed by the amygdala (AMG) and the medial Prefrontal Cortex (mPFC), at the interface between our internal and external environment, has been shown to support some important aspects of behavioral adaptation. Whether and how the...
Introducing individual sentience profiles in nonhuman primate neuroscience research [0.03%]
在非人灵长类神经科学研究中引入个体意识特征档案表
Angelica Kaufmann
Angelica Kaufmann
The Animal Research Declaration is committed to establishing cohesive and rigorous ethical standards to safeguard the welfare of nonhuman primates (NHPs) engaged in neuroscience research (Petkov et al., 2022 this issue). As part of this mis...
Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models [0.03%]
普萘洛尔可减少C9orf72-ALS/FTD体外模型中细胞毒性聚集体的积累
Mira Seidel,Sandeep Rajkumar,Christina Steffke et al.
Mira Seidel et al.
Mutations in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The pathogenetic mechanisms linked to this gene are a direct consequence of an aberrant intronic expa...
Protocol for a Wnt reporter assay to measure its activity in human neural stem cells derived from induced pluripotent stem cells [0.03%]
测量人诱导多能干细胞来源神经干细胞中Wnt活性的报告基因实验方案
Cristine Marie Yde Ohki,Natalie Monet Walter,Michelle Rickli et al.
Cristine Marie Yde Ohki et al.
The canonical Wnt signaling is an essential pathway that regulates cellular proliferation, maturation, and differentiation during neurodevelopment and maintenance of adult tissue homeostasis. This pathway has been implicated with the pathop...
Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome [0.03%]
progranulin是Fragile X综合征小鼠模型中FMRP的靶标并影响大睾丸症但不影响行为
Benjamin Life,Luis E B Bettio,Ilse Gantois et al.
Benjamin Life et al.
A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease. Specifically, increased progranulin expression in the prefrontal cor...
Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke [0.03%]
急性卒中期间猴脑二级躯体感觉皮层(S2)功能连接改变的纵向评估
Chun-Xia Li,Frank Tong,Doty Kempf et al.
Chun-Xia Li et al.
Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In...
Are there disciplinary boundaries in the comparative study of primate cognition? [0.03%]
灵长类认知的比较研究中有学科界限吗？
Héctor M Manrique,Juan J Canales
Héctor M Manrique
A view continues to gain momentum that regards investigation of the cognition of great apes in captive settings as affording us a model for human cognitive evolution. Researchers from disciplines such as comparative psychology, anthropology...