Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques [0.03%]
杏仁体-前额叶回路中的多重通讯途径：人和恒河猴的比较研究
C Giacometti,C Amiez,F Hadj-Bouziane
C Giacometti
The network formed by the amygdala (AMG) and the medial Prefrontal Cortex (mPFC), at the interface between our internal and external environment, has been shown to support some important aspects of behavioral adaptation. Whether and how the...
Introducing individual sentience profiles in nonhuman primate neuroscience research [0.03%]
在非人灵长类神经科学研究中引入个体意识特征档案表
Angelica Kaufmann
Angelica Kaufmann
The Animal Research Declaration is committed to establishing cohesive and rigorous ethical standards to safeguard the welfare of nonhuman primates (NHPs) engaged in neuroscience research (Petkov et al., 2022 this issue). As part of this mis...
Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models [0.03%]
普萘洛尔可减少C9orf72-ALS/FTD体外模型中细胞毒性聚集体的积累
Mira Seidel,Sandeep Rajkumar,Christina Steffke et al.
Mira Seidel et al.
Mutations in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The pathogenetic mechanisms linked to this gene are a direct consequence of an aberrant intronic expa...
Protocol for a Wnt reporter assay to measure its activity in human neural stem cells derived from induced pluripotent stem cells [0.03%]
测量人诱导多能干细胞来源神经干细胞中Wnt活性的报告基因实验方案
Cristine Marie Yde Ohki,Natalie Monet Walter,Michelle Rickli et al.
Cristine Marie Yde Ohki et al.
The canonical Wnt signaling is an essential pathway that regulates cellular proliferation, maturation, and differentiation during neurodevelopment and maintenance of adult tissue homeostasis. This pathway has been implicated with the pathop...
Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome [0.03%]
progranulin是Fragile X综合征小鼠模型中FMRP的靶标并影响大睾丸症但不影响行为
Benjamin Life,Luis E B Bettio,Ilse Gantois et al.
Benjamin Life et al.
A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease. Specifically, increased progranulin expression in the prefrontal cor...
Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke [0.03%]
急性卒中期间猴脑二级躯体感觉皮层(S2)功能连接改变的纵向评估
Chun-Xia Li,Frank Tong,Doty Kempf et al.
Chun-Xia Li et al.
Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In...
Are there disciplinary boundaries in the comparative study of primate cognition? [0.03%]
灵长类认知的比较研究中有学科界限吗？
Héctor M Manrique,Juan J Canales
Héctor M Manrique
A view continues to gain momentum that regards investigation of the cognition of great apes in captive settings as affording us a model for human cognitive evolution. Researchers from disciplines such as comparative psychology, anthropology...
Maresin-2 inhibits inflammatory and neuropathic trigeminal pain and reduces neuronal activation in the trigeminal ganglion [0.03%]
maresin-2抑制三叉神经炎症性和神经病理性疼痛并减少三叉神经节神经元活化
Raphael Vieira Lopes,Darciane Favero Baggio,Camila Rodrigues Ferraz et al.
Raphael Vieira Lopes et al.
Pain is a common symptom associated with disorders involving the orofacial structures. Most acute orofacial painful conditions are easily recognized, but the pharmacological treatment may be limited by the adverse events of current availabl...
Chelsey C Damphousse,Jaclyn K Medeiros,Nicole E Micks et al.
Chelsey C Damphousse et al.
Type 2 diabetes mellitus has steadily increased in prevalence over the past five decades. Among the health risks associated with this disorder are cognitive decline and are increased risk of developing dementia. To further investigate the l...
Optogenetic stimulation of the primary visual cortex drives activity in the visual association cortex [0.03%]
初级视觉皮层的光遗传学刺激驱动视觉相关皮层的活动
Michael Ortiz-Rios,Beshoy Agayby,Fabien Balezeau et al.
Michael Ortiz-Rios et al.
Developing optogenetic methods for research in non-human primates (NHP) is important for translational neuroscience and for delineating brain function with unprecedented specificity. Here we assess, in macaque monkeys, the selectivity by wh...