The secretome of senescent monocytes predicts age-related clinical outcomes in humans [0.03%]
衰老单核细胞的分泌组预测人类年龄相关的临床结果
Bradley Olinger,Reema Banarjee,Amit Dey et al.
Bradley Olinger et al.
Cellular senescence increases with age and contributes to age-related declines and pathologies. We identified circulating biomarkers of senescence and related them to clinical traits in humans to facilitate future noninvasive assessment of ...
Editing epigenetic age [0.03%]
编辑表观遗传年龄
Bastiaan T Heijmans
Bastiaan T Heijmans
Mid-life adipogenesis [0.03%]
中年脂肪生成
George Andrew S Inglis
George Andrew S Inglis
A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions [0.03%]
基于转录组的人类普遍衰老指数(hUSI)可预测各种条件下的细胞衰老现象
Jing Wang,Xiaolan Zhou,Peng Yu et al.
Jing Wang et al.
Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited mark...
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan [0.03%]
雷帕霉素和曲马替尼在延长小鼠健康寿命和寿命方面具有增效作用
Lisonia Gkioni,Tobias Nespital,Maarouf Baghdadi et al.
Lisonia Gkioni et al.
Suppression of the insulin-IGF-mTORC1-Ras network ameliorates aging in animals. Many drugs have targets in the network because of its roles in cancer and metabolic disease and are candidates for repurposing as geroprotectors. Rapamycin, an ...
Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits [0.03%]
利用头方向网络中的非规范前庭输入来矫正与年龄有关的导航缺陷
Xiao-Qian Hu,Kenneth Lap-Kei Wu,Kang-Lin Rong et al.
Xiao-Qian Hu et al.
Navigational decline is a metric distinct from aging-related cognitive degradation, yet the affected circuits and synaptic changes remain elusive. This study identified a long-range excitatory projection from parvalbumin (PV) neurons in the...
Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity [0.03%]
胰岛素和Notch信号通过神经元CREB活性调节记忆
Shiyi Zhou,Katherine E Novak,Rachel Kaletsky et al.
Shiyi Zhou et al.
While memory regulation is predominantly understood as autonomous to neurons, factors outside the brain can also affect neuronal function. In Caenorhabditis elegans, the insulin/IGF-1-like signaling (IIS) pathway regulates longevity, metabo...
Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging [0.03%]
线粒体克隆镶嵌编码衰老的双相分子钟
Zhenguo Wang,Zhe Li,Hongyu Liu et al.
Zhenguo Wang et al.
Mitochondria rapidly accumulate mutations throughout a lifetime, potentially acting as a molecular clock for aging and disease. We profiled mitochondrial RNA across 47 human tissues from 838 individuals, revealing rapid development of clona...