The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan
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Suppression of the insulin-IGF-mTORC1-Ras network ameliorates aging in animals. Many drugs have targets in the network because of its roles in cancer and metabolic disease and are candidates for repurposing as geroprotectors. Rapamycin, an established geroprot... ...
