David Furman
David Furman
The aging extracellular matrix as a missing link in senescent cell accumulation and persistence [0.03%]
衰老的细胞外基质在衰老细胞积累和持续存在中的作用
Natalia Hernández-Bellido,Aida Perramon-Güell,Carlos Anerillas
Natalia Hernández-Bellido
Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs [0.03%]
多模态数据分析揭示女性生殖器官衰老的动力学异步性
Oleksandra Soldatkina,Laura Ventura-San Pedro,Natàlia Pujol-Gualdo et al.
Oleksandra Soldatkina et al.
Female reproductive aging has systemic health implications, yet tissue-level dynamics remain poorly understood. Here we integrate deep learning analysis of 1,112 histology images with RNA sequencing from 659 samples across seven female repr...
Connecting fragmented aging research through the European Federation for Aging Research [0.03%]
通过欧洲老化研究联合会连接碎片化的老龄化研究
Björn Schumacher,Morten Scheibye-Knudsen,Lene Juel Rasmussen et al.
Björn Schumacher et al.
Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization [0.03%]
利用药物靶点孟德尔随机化证据重新定位预防血管性痴呆的药物
Victoria Taylor-Bateman,Phazha Bothongo,Venexia Walker et al.
Victoria Taylor-Bateman et al.
Vascular dementia (VaD) is a devastating cerebrovascular disease with no disease-modifying treatments. Repurposing drugs for known risk factors could have clinical impact. Using Mendelian randomization, we proxied 46 lipid-lowering, antihyp...
p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease [0.03%]
P21+ TREM2+衰老巨噬细胞驱动炎症和代谢紊乱相关肝脂变性疾病
Ivan A Salladay-Perez,Itzetl Avila,Lizeth Estrada et al.
Ivan A Salladay-Perez et al.
Cellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype, yet the senescent cell types responsible are poorly defined. Macrophages share multiple features of senescence, includin...
Maria Papatriantafyllou
Maria Papatriantafyllou
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging [0.03%]
人体热量限制的外泌体蛋白组鉴定补体失活为一种可降低炎症衰老的免疫代谢检查点
Manish Mishra,Hee-Hoon Kim,Yun-Hee Youm et al.
Manish Mishra et al.
Caloric restriction (CR) extends lifespan across diverse organisms, but the effects of CR on human aging and on healthspan are only beginning to be uncovered. In this study, we applied proteomics to plasma samples collected longitudinally f...
Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence [0.03%]
单细胞分析揭示人类免疫系统的性别特异性免疫衰老动力学
Maria Sopena-Rios,Aida Ripoll-Cladellas,Fatemeh Omidi et al.
Maria Sopena-Rios et al.
Immunosenescence, the progressive aging of the immune system, is characterized by changes in immune cell composition and function that increase susceptibility to disease. However, how biological sex shapes immune aging at the cellular level...