Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America [0.03%]
拉丁美洲阿尔茨海默病和额颞叶变性的血液AT(N)生物标志物
Ariel Caviedes,Felipe Cabral-Miranda,Paulina Orellana et al.
Ariel Caviedes et al.
Dementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and environmental heterogeneity, is particularly un...
Virtual assistant enhances health outcomes in older adults with type 2 diabetes [0.03%]
虚拟助手可改善老年人2型糖尿病的治疗效果
Yahyah Aman
Yahyah Aman
Hannah Walters
Hannah Walters
Exploratory analyses of clinical outcomes from the BIIB080 phase 1b study in mild Alzheimer's disease [0.03%]
BIIB080治疗轻度阿尔茨海默病患者的Ib期临床研究的探索性分析结果
Melanie Shulman,Shuang Wu,Nick Ziogas et al.
Melanie Shulman et al.
This study conducted exploratory analyses of the effects of BIIB080, a MAPT (microtubule-associated protein tau)-targeting antisense oligonucleotide, in participants with mild Alzheimer's disease. A multicenter, randomized, double-blind, ph...
Implementing a nationwide healthy longevity program for older adults [0.03%]
实现在全国范围内开展老年人健康老龄化项目的策略
Bruno Vellas
Bruno Vellas
Exposure to low-credibility online health content is limited and is concentrated among older adults [0.03%]
接触低可信度的在线健康内容有限，并且集中在老年人群中
Benjamin Lyons,Andy J King,Rebecca L Barter et al.
Benjamin Lyons et al.
Older adults have been shown to engage more with untrustworthy online content, but most digital trace research has focused on political misinformation. In contrast, studies of health misinformation have largely relied on self-reported surve...
Yuan Wang
Yuan Wang
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome [0.03%]
肺癌和卵巢癌对基于铂的化疗产生耐药性是由一个可靶向的TGFβ衰老分泌组驱动的
Estela González-Gualda,Marika A V Reinius,David Macias et al.
Estela González-Gualda et al.
Platinum-based chemotherapy is commonly used for non-small cell lung cancer (NSCLC) and high-grade serous ovarian cancer (HGSOC) treatments, yet clinical outcomes remain poor. Cellular senescence and its associated secretory phenotype (SASP...
Saima Hassan,Gerardo Ferbeyre
Saima Hassan
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions [0.03%]
衰老时钟确定神经元类型对神经退行性疾病易感或抗性，并识别神经营养保护干预措施
Christian Gallrein,David H Meyer,Yvonne Woitzat et al.
Christian Gallrein et al.
Different neuron types show distinct susceptibility to age-dependent degeneration, yet the underlying mechanisms are poorly understood. Here we applied aging clocks to single neuron types in Caenorhabditis elegans and found that distinct ne...