The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome [0.03%]
中年期大脑健康的血液代谢组及基因、微生物和暴露组的影响
Shahzad Ahmad,Tong Wu,Matthias Arnold et al.
Shahzad Ahmad et al.
Metabolic alterations are increasingly implicated in neurological disorders, including Alzheimer's disease (AD), highlighting the relevance of the peripheral metabolome, shaped by genetic and environmental exposures, for brain health. We ex...
Marta Guasch-Ferré
Marta Guasch-Ferré
Raúl F Pérez,Juan Ramón Tejedor,Agustín F Fernández et al.
Raúl F Pérez et al.
Mahmoud Abdellatif,Yevgeniy Kim,Guido Kroemer
Mahmoud Abdellatif
Geroscience has advanced rapidly, yet its clinical translation remains limited. A central barrier is the lack of trial outcomes that capture the multidimensional effects of geroprotective interventions while meeting clinical and regulatory ...
Are GLP-1 receptor agonists gerotherapeutics or just treatments for obesity? [0.03%]
GLP-1受体激动剂是抗衰老药物还是仅仅用于治疗肥胖？
James G Peyer
James G Peyer
Reaching for the cure as progeria research comes of age at the 12th international scientific workshop [0.03%]
第十二届国际科研工作者研讨会：探究哈氏(progeria)症治疗方法
Maria Eriksson,Vicente Andrés,Mark W Kieran et al.
Maria Eriksson et al.
Tammy C T Lan,Alison Kochersberger,Ruth Raichur et al.
Tammy C T Lan et al.
Throughout the female reproductive lifespan, the ovary undergoes hundreds of cycles of follicle development, ovulation and tissue regeneration. How aging disrupts the coordination of such precise, multicellular interactions across time and ...
Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling [0.03%]
转录组分析揭示衰老小鼠体内细胞衰老治疗的分子和生理效应涉及免疫反应、纤维化以及代谢重塑作用
Jing Hou,Kai-Xuan Chen,Qiao-Ni Xiao et al.
Jing Hou et al.
Although senolytics such as dasatinib and quercetin (D+Q) show promise in modulating aging, their tissue-specific efficacy and optimal intervention timing remain poorly understood. Given D+Q's potential off-target effects, incomplete senesc...
Nuclear export of R-loop by the DDX1 and XPO1 complex promotes senescence-associated secretory phenotype and inflammaging [0.03%]
DDX1和XPO1复合体通过R-环的核输出促进衰老相关分泌表型和炎性衰老现象
Xue Hao,Bo Zhao,Qingqing Yan et al.
Xue Hao et al.
Cellular senescence contributes to inflammaging in part through the senescence-associated secretory phenotype (SASP). R-loops, three-stranded nucleic acid structures, contribute to innate immune response in cancers; however, the role of R-l...
Steven N Austad
Steven N Austad