Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish [0.03%]
Gabriele Morabito,Handan Melike Dönertas,Luca Sperti et al.
Gabriele Morabito et al.
Turquoise killifish (Nothobranchius furzeri) are naturally short-lived vertebrates that recapitulate key aspects of human aging. However, the molecular and cellular causes of systemic aging in killifish are poorly understood. Here we ask wh...
Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort [0.03%]
纵向表观遗传钟变化可预测InCHIANTI队列的生存率
Pei-Lun Kuo,Ann Zenobia Moore,Toshiko Tanaka et al.
Pei-Lun Kuo et al.
Epigenetic clocks derived from DNA methylation patterns are among the most promising biomarkers of biological aging1-7, as they capture molecular signatures that predict morbidity and mortality beyond chronological age. Although cross-secti...
Anna Kriebs
Anna Kriebs
Microglia protein profiles in CSF across Alzheimer's disease clinical stages [0.03%]
阿尔茨海默病临床分期的脑脊液中小胶质细胞蛋白谱型分布
Elena-Raluca Blujdea,Pieter van Bokhoven,Pamela V Martino-Adami et al.
Elena-Raluca Blujdea et al.
Microglia are implicated in the progression of Alzheimer's disease (AD) pathology from its earliest stages, suggesting that cerebrospinal fluid (CSF) microglia profiling across clinical AD stages can aid in treatment development and monitor...
Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age [0.03%]
空间转录组学和形态学分析工具可探究微胶质细胞如何随年龄变化而改变
Douglas E Henze,Andy P Tsai,Tony Wyss-Coray et al.
Douglas E Henze et al.
Cellular morphology is tightly linked to function, but how subcellular transcript localization contributes remains unclear. Using microglia, the brain's resident macrophages, as a model, we combined multiplexed error-robust fluorescence in ...
Thomas Nedelec,Jean-Christophe Corvol
Thomas Nedelec
The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging [0.03%]
糖酵解代谢产物磷酸烯醇式丙酮酸通过限制cGAS驱动的炎症来促进健康衰老
Zengqing Song,Huaibin Hu,Wanpeng Zhang et al.
Zengqing Song et al.
Aging involves multiple detrimental changes in the systemic milieu, leading to functional deterioration and age-related diseases. However, the potential self-protective adaptive alterations during aging remain underexplored. Here we show th...
Erlin Wang,Jianxiong Zeng
Erlin Wang
Tomas Schmauck-Medina,Sofie Lautrup,Andrea Di Francesco et al.
Tomas Schmauck-Medina et al.
Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular levels proliferated....