Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging [0.03%]
衰老过程中老化组织中性别差异及细胞类型特异性变化的分子伴侣介导的自噬现象
Rabia R Khawaja,Adrián Martín-Segura,Olaya Santiago-Fernández et al.
Rabia R Khawaja et al.
Aging leads to progressive decline in organ and tissue integrity and function, partly due to loss of proteostasis and autophagy malfunctioning. A decrease with age in chaperone-mediated autophagy (CMA), a selective type of lysosomal degrada...
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target [0.03%]
肌少症的多组学分析识别出支链氨基酸分解代谢紊乱是因果机制和治疗靶点
Xinrong Zuo,Rui Zhao,Minming Wu et al.
Xinrong Zuo et al.
Sarcopenia is a geriatric disorder characterized by a gradual loss of muscle mass and function. Despite its prevalence, the underlying mechanisms remain unclear, and there are currently no approved treatments. In this study, we conducted a ...
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial [0.03%]
维生素D、欧米茄-3和运动对老年人表观遗传衰老的影响：DO-HEALTH试验结果
Heike A Bischoff-Ferrari,Stephanie Gängler,Maud Wieczorek et al.
Heike A Bischoff-Ferrari et al.
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the resul...
Author Correction: Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog [0.03%]
作者更正：使用米勒封装苏丹黑B连接模拟物生成选择性senolytic平台
Sophia Magkouta,Dimitris Veroutis,Angelos Papaspyropoulos et al.
Sophia Magkouta et al.
Published Erratum
Nature aging. 2025 Jan 31. DOI:10.1038/s43587-025-00820-6 2025
A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice [0.03%]
一种BCL-xL/BCL-2蛋白降解剂有效清除小鼠肝脏中衰老细胞并减少MASH驱动的肝细胞癌
Yang Yang,Natacha Jn-Simon,Yonghan He et al.
Yang Yang et al.
Accumulation of senescent cells (SnCs) plays a causative role in many age-related diseases and has also been implicated in the pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Senolytics that...
Chien-Wei Lee,Belle Yu-Hsuan Wang,Shing Hei Wong et al.
Chien-Wei Lee et al.
Various anti-aging interventions show promise in extending lifespan, but many are ineffective or even harmful to healthspan. Ginkgolide B (GB), derived from Ginkgo biloba, reduces aging-related morbidities such as osteoporosis, yet its effe...
Author Correction: Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types [0.03%]
作者更正：异步型连体改变小鼠大脑转录组程序通过多个细胞类型中衰老标志物的变化实现
Methodios Ximerakis,Kristina M Holton,Richard M Giadone et al.
Methodios Ximerakis et al.
Published Erratum
Nature aging. 2025 Jan 29. DOI:10.1038/s43587-025-00804-6 2025
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells [0.03%]
小生境衍生的神经纤毛蛋白4A保护髓系偏向性造血干细胞的功能特性
Dorsa Toghani,Sanika Gupte,Sharon Zeng et al.
Dorsa Toghani et al.
Somatic stem cell pools comprise diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased hematopoietic stem cells (myHSCs) are indispensable for...
Bernadette Hotzi,Tibor Vellai
Bernadette Hotzi