Adrenocortical carcinoma: selective internal radiation therapy and liver metastases [0.03%]
肾上腺皮质癌：选择性体内放射治疗与肝转移灶
Leo Baxendale-Smith,Karim El-Shakankery,James Gordon-Smith et al.
Leo Baxendale-Smith et al.
Selective internal radiation therapy (SIRT) is a novel intervention for both primary and metastatic malignant liver lesions. Adrenocortical carcinoma (ACC) is rare with limited treatment options; evidence for SIRT in ACC liver metastases co...
Tolerability and outcomes of neuroendocrine tumors treated with PRRT and SBRT [0.03%]
神经内分泌肿瘤接受肽受体放射性核素疗法和立体定向身体放疗的耐受性和结果分析
Jose E Nunez,Sylvia Ng,Hanbo Chen et al.
Jose E Nunez et al.
There is interest in optimizing peptide receptor radionuclide therapy (PRRT) for the management of metastatic neuroendocrine neoplasms (NEN). The addition of stereotactic body radiation therapy (SBRT) may provide synergistic benefits by tar...
SDHA secondary findings in germline testing: counseling and surveillance considerations [0.03%]
遗传学检测中SDHA继发性发现：咨询和监测方面的考虑因素
Catherine M Skefos,Pamela L Brock,Erica Blouch et al.
Catherine M Skefos et al.
This commentary explores the complexities faced by clinicians when encountering a secondary SDHA pathogenic variant (PV) in patients without a personal or family history of SDHA-related tumors. The increasing use of germline multi-gene pane...
Vasiliki Venetsanaki,Eleana Zisimopoulou,Chrysanthi Zouli et al.
Vasiliki Venetsanaki et al.
Background: Mönckeberg sclerosis is a form of calcification of the tunica media of small and medium size arteries. It occurs more often in the peripheral arteries of the lower limbs and it has been associated with diabet...
Dheeratama Siripongsatian,Quido G de Lussanet de la Sablonière,Frederik Anton Verburg et al.
Dheeratama Siripongsatian et al.
The field of nuclear theranostic clinical trials is continuously expanding as an increasing number of novel agents and treatment combinations are explored for treating advanced and metastatic cancers. Moving from 'bench-to-bedside' is often...
MDM2 regulates the stability of AR, AR-V7, and TM4SF3 proteins in prostate cancer [0.03%]
MDM2在前列腺癌中调节AR，AR-V7和TM4SF3蛋白质的稳定性
Prabesh Khatiwada,Ujjwal Rimal,Zhengyang Han et al.
Prabesh Khatiwada et al.
Androgen receptor (AR) and its constitutively active splice variant, AR Variant 7 (AR-V7), regulate genes essential for the development and progression of prostate cancer. Degradation of AR and AR-V7 by the ubiquitination proteasomal pathwa...
The GLP-1 receptor is expressed in vivo by human metastatic prostate cancer [0.03%]
GLP-1受体是由人转移性前列腺癌表达的效应物
Mark S Stein,Victor Kalff,Scott G Williams et al.
Mark S Stein et al.
Objectives: The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce in vitro proliferation and in vivo growth of prostate canc...
Metyrosine-associated endocrinological changes in pheochromocytoma and paraganglioma [0.03%]
metyrosine与pheochromocytoma和paraganglioma相关的内分泌变化
Yuko Matsuo,Kenji Ashida,Ayako Nagayama et al.
Yuko Matsuo et al.
Objective: Metyrosine (alpha-methyl-para-tyrosine) effectively reduces catecholamine levels in patients with pheochromocytoma/paraganglioma. However, improvements in physiological and metabolic parameters and changes in e...
Peptides disrupting TM4SF3 interaction with AR or AR-V7 block prostate cancer cell proliferation [0.03%]
能够破坏TM4SF3与AR或AR-V7相互作用的肽可抑制前列腺癌细胞增殖
Prabesh Khatiwada,Ujjwal Rimal,Mamata Malla et al.
Prabesh Khatiwada et al.
Androgen receptor (AR) plays a vital role in the development and progression of prostate cancer from the primary stage to the usually lethal stage known as castration-resistant prostate cancer (CRPC). Constitutively active AR splice variant...
Molly Endicott,Chrissie Thirlwell,Amy P Webster
Molly Endicott
Diabetes and cancer are two heterogenous diseases which are rapidly increasing in prevalence globally. A link between these two non-communicable diseases was first identified over 100 years ago; however, recent epidemiological studies and a...