Metformin modifies hormone changes associated with androgen deprivation therapy for prostate cancer [0.03%]
二甲双胍可改变前列腺癌雄激素剥夺治疗相关的激素变化
Mathew Gorman,Nawaid Usmani,Michael N Pollak et al.
Mathew Gorman et al.
Androgen deprivation therapy (ADT) is regularly used to treat locally advanced and metastatic prostate cancer (PCa) with toxicities, including metabolic syndrome (MS) and associated adverse hormonal changes. This study evaluated whether met...
Functional and behavioral outcomes in pediatric adrenal carcinoma under mitotane therapy: a caregiver-reported pilot study [0.03%]
儿科肾上腺癌患者在米托坦治疗下的功能和行为结局：一项基于照料者报告的试点研究
Heidi Frey,Maria Riedmeier,Johanna Krüger et al.
Heidi Frey et al.
Objective: Mitotane is the standard therapy for advanced pediatric adrenocortical carcinoma (pACC). With improving survival, treatment-related long-term side effects and their impact on everyday functioning are becoming i...
Pathogenic germline variants identified in pNEN patients during genetic testing [0.03%]
遗传检测中pNEN患者致病性种系变异的鉴定
Tara Arouchian,Alexandra Gangi,Ka Wing Fung et al.
Tara Arouchian et al.
Poor outcomes in pancreatic neuroendocrine neoplasms (pNENs) partially result from the inability to identify early-stage disease in patients. Prevention strategies have focused on identifying high-risk patients through genetic susceptibilit...
Metastatic neuroendocrine lesions in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): a narrative review and case series [0.03%]
弥漫性特发性肺神经内分泌细胞增生症(DIPNECH)的转移性神经内分泌病变：病例系列和文献综述
David C Llewellyn,Saoirse Dolly,John K Ramage et al.
David C Llewellyn et al.
Objective: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare entity characterised by the proliferation of neuroendocrine cells in the respiratory epithelium. DIPNECH is a pre-neoplastic cond...
Trends in metastatic thyroid cancer survival from 1992 to 2022: a SEER database analysis [0.03%]
1992年至2022年转移性甲状腺癌生存率的变迁：来自SEER数据库的分析结果
Ashwin Govindan,Philippos Apolinario Costa,Richard Feinn et al.
Ashwin Govindan et al.
The majority of thyroid cancers present as localized disease that is treated with surgery or radioactive iodine. Despite the effectiveness of radioactive iodine, 5-10% of thyroid cancers are radioiodine-resistant and are termed radioiodine-...
A contemporary overview of multiple endocrine neoplasia syndromes: MEN syndromes 1-5 and beyond [0.03%]
当代遗传性内分泌肿瘤综合征(MEN1-5及其他)概述
Raquel A Maggacis,Alexandra Sorvina,Lisa J Hayes et al.
Raquel A Maggacis et al.
Multiple endocrine neoplasia (MEN) syndromes constitute a heterogeneous group of hereditary disorders predisposing to endocrine tumours of varying malignant potential. Recent advances in molecular genetics and tumour biology have significan...
Differential expression of POMC-processing genes in corticotroph tumors [0.03%]
促肾上腺皮质激素细胞肿瘤中POMC加工基因的差异表达
Elisa Lamback,Renan L Miranda,Laryssa Mendonça et al.
Elisa Lamback et al.
Objective: Corticotroph tumors (CTs) derive from the TBX19 lineage and are functioning (FCTs) or nonfunctioning (NFCTs). In FCTs, the main pathogenic variants are found in USP8, enhancing proopiomelanocortin (POMC) transc...
Evaluating the clinical utility of iodine-123 scans in follow-up for differentiated thyroid cancer: a single-centre study [0.03%]
碘-123显像在分化型甲状腺癌术后随访中的临床应用价值研究：单中心报告
Robert Smith-Baker,Richard Meades,Arunansu Kar
Robert Smith-Baker
Objective: To evaluate the impact of iodine-123 (I-123) diagnostic scintigraphy on management outcomes in patients undergoing follow-up for differentiated thyroid carcinoma (DTC), and to assess whether multidisciplinary t...
Therapy-related myeloid neoplasms following peptide receptor radionuclide therapy for neuroendocrine neoplasms: case series reporting characteristics and outcomes from single-centre experience [0.03%]
肽受体放射核素治疗神经内分泌肿瘤后的治疗相关骨髓瘤：单一中心经验的病例系列报告特征和结果
Wallace Chow,Ivy Wen,Claire Mok et al.
Wallace Chow et al.
Objective: Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTATATE is increasingly used in the treatment of metastatic neuroendocrine neoplasms (NENs). Marrow toxicity resulting in therapy-related myeloid neo...
The clinical impact of androgens in endometrial cancer: cancer promoter or suppressor? [0.03%]
雄激素在子宫内膜癌中的临床影响：致癌物或抑制物？
Xirong Wu,Wenyan Tian,Yingmei Wang
Xirong Wu
Purpose: Androgens are associated with the risk of endometrial carcinoma (EC). However, their roles as prognostic factors are less clear. This study aims to investigate the prognostic impact of different androgens. ...