Show-Ling Shyng
Show-Ling Shyng
Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells [0.03%]
胰岛内分泌和非内分泌细胞中的细胞因子和一氧化氮依赖性基因调节作用
Jennifer S Stancill,Moujtaba Y Kasmani,Achia Khatun et al.
Jennifer S Stancill et al.
While exposure to inflammatory cytokines is thought to contribute to pancreatic β-cell damage during diabetes, primarily because cytokine-induced nitric oxide impairs β-cell function and causes cell death with prolonged exposure, we hypot...
Nucleus Type-Specific DNA Methylomics Reveals Epigenetic "Memory" of Prior Adaptation in Skeletal Muscle [0.03%]
特定核型DNA甲基组学揭示了骨骼肌先前适应的表观遗传“记忆”
Yuan Wen,Cory M Dungan,C Brooks Mobley et al.
Yuan Wen et al.
Using a mouse model of conditional and inducible in vivo fluorescent myonuclear labeling (HSA-GFP), sorting purification of nuclei, low-input reduced representation bisulfite sequencing (RRBS), and a translatable and reversible model of exe...
B0AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation Analysis [0.03%]
B0AT1氨基酸转运蛋白与SARS-CoV-2受体ACE2形成的异二聚体功能单元复合物：使用辐射失活分析的原位构象研究
Bruce R Stevens,J Clive Ellory,Robert L Preston
Bruce R Stevens
The SARS-CoV-2 receptor, angiotensin-converting enzyme-2 (ACE2), is expressed at levels of greatest magnitude in the small intestine as compared with all other human tissues. Enterocyte ACE2 is coexpressed as the apical membrane trafficking...
Nitric Oxide Signals Through IRAG to Inhibit TRPM4 Channels and Dilate Cerebral Arteries [0.03%]
一氧化氮通过IRAG抑制TRPM4通道并扩张脑动脉
Sher Ali,Alfredo Sanchez Solano,Albert L Gonzales et al.
Sher Ali et al.
Nitric oxide (NO) relaxes vascular smooth muscle cells (SMCs) and dilates blood vessels by increasing intracellular levels of cyclic guanosine monophosphate (cGMP), which stimulates the activity of cGMP-dependent protein kinase (PKG). Howev...
Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle [0.03%]
轻度认知障碍和多奈哌齐影响骨骼肌的线粒体呼吸能力
Jill K Morris,Colin S McCoin,Kelly N Fuller et al.
Jill K Morris et al.
Alzheimer's Disease (ad) associates with insulin resistance and low aerobic capacity, suggestive of impaired skeletal muscle mitochondrial function. However, this has not been directly measured in AD. This study ( n = 50) compared muscle mi...
Regulation of Neutral Amino Acid Transport By the SARS-CoV-2 Receptor ACE2 [0.03%]
SARS-CoV-2受体ACE2对中性氨基酸转运的调控
Donald D F Loo,Ernest M Wright
Donald D F Loo
Ole H Petersen
Ole H Petersen
Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels [0.03%]
创伤性脑损伤通过扰乱内向整流钾通道损害全身血管功能
Adrian M Sackheim,Nuria Villalba,Maria Sancho et al.
Adrian M Sackheim et al.
Trauma can lead to widespread vascular dysfunction, but the underlying mechanisms remain largely unknown. Inward-rectifier potassium channels (Kir2.1) play a critical role in the dynamic regulation of regional perfusion and blood flow. Kir2...