Cellular Senescence Links Muscle Atrophy and Posttraumatic Osteoarthritis after ACL Injury [0.03%]
半月板损伤后细胞衰老与肌肉萎缩和创伤性骨关节炎之间的联系
Alexander R Keeble,Allison Owen,Sara Gonzalez-Velez et al.
Alexander R Keeble et al.
Traumatic knee injury leads to posttraumatic osteoarthritis (PTOA) and significant skeletal muscle weakness, resulting in chronic disability. The current standard of care frequently fails to prevent musculoskeletal dysfunction, underscoring...
Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats [0.03%]
circadian钟蛋白Bmal1通过调节雄性大鼠呼吸运动的可塑性来调控呼吸功能
Aaron A Jones,Alexandria Beverly Marciante,Pierce Berardi et al.
Aaron A Jones et al.
Acute intermittent hypoxia (AIH) elicits respiratory motor plasticity in the phrenic, intercostal, and hypoglossal motor pools, and has emerged as a promising therapeutic strategy to improve respiratory function in people with neuromuscular...
Luke S Dunaway
Luke S Dunaway
A healthy cardiovascular system requires a healthy endothelium. The endothelium is a central regulator of hemostasis, vascular permeability, inflammation, blood pressure, and, perhaps most fundamentally, blood flow1. It is therefore of no s...
Layer-Specific Choroidal Vascular Adaptation to High-Altitude Hypoxia Revealed by Functional OCT at 3,800 m [0.03%]
基于功能光学 coherence tomography 的层特异性脉络膜血管在高原低氧中的适应变化（3800 米）
Mohammad Amin Safarzadeh,Jacquie Baker,Satish R Raj et al.
Mohammad Amin Safarzadeh et al.
Ascent to high-altitude induces systemic and ocular changes that alter vision. The functional responses of the choroidal vasculature at different depths to hypoxia remain incompletely understood. In this study, we employed functional optica...
Aberrant Activation of Renal Functional Reserve and Reduced Tubule Flow, but not Obstruction, is Associated with Cystogenesis in Pkd2 Mutant Kidneys [0.03%]
多囊肾PKD2突变肾脏中肾功能储备的异常激活和肾小管血流减少与肾囊肿的发生相关，但梗阻无关
Isis N Thomas,Sneha Rajendran,Zhang Li et al.
Isis N Thomas et al.
Disruption of PKD2 function causes polycystic kidney disease (PKD) and leads to the formation of cysts in the kidney in both mice and humans. PKD is progressive, initiating with the formation of tubule dilations that expand into large cysts...
Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle [0.03%]
肝脏生酮不足会降低运动引起的能量消耗并改变骨骼肌中的线粒体蛋白质
Xin C Davis,Colin S McCoin,Sebastian F Salathe et al.
Xin C Davis et al.
Ketone body (KB) utilization increases during fasting and exercise due to enhanced hepatic fatty acid oxidation and KB production via the rate-limiting mitochondrial enzyme hydroxymethylglutaryl-CoA synthase (HMGCS2). Since KB metabolism in...
Role for endothelin-1 in cardiometabolic dysfunction with intermittent hypoxia [0.03%]
间歇性缺氧引起的心代谢功能障碍与内皮素-1的作用
Anna M Gonsalves,Sarah E Baker,Prachi Singh et al.
Anna M Gonsalves et al.
Endothelin-1 (ET-1) has been linked to increased hypoxic sensitivity of the chemoreceptors and the development of cardiometabolic disease. Repeated hypoxic exposures (i.e., intermittent hypoxia, IH) elicit increases in ET-1, muscle sympathe...
Melatonin Receptor Signaling in Human Pathologies: From Molecular Mechanisms to Therapeutic Targets [0.03%]
人病理学中的褪黑激素受体信号转导：从分子机制到治疗靶点
Yen-Sung Huang,Sheng-Ding Wu,Hsi-Chih Chen et al.
Yen-Sung Huang et al.
The Melatonin Receptor 1A (MTNR1A), a highly conserved G protein-coupled receptor (GPCR), mediates crucial physiological functions. Its structure features an N-terminus responsible for melatonin binding and a C-terminus that initiates downs...
Hepatic ketogenesis is not required for exercise training to mitigate diet-induced liver steatosis in male mice [0.03%]
肝脏酮体生成对于运动训练缓解小鼠饮食诱导的肝脂肪变性不是必需的
Cha Mee Vang,Andres F Ortega,Ruth E Pfeiffer et al.
Cha Mee Vang et al.
Accelerated hepatic fatty acid oxidation during acute exercise has been proposed as a contributor to the anti-steatotic effects of exercise training. Ketogenesis, which produces acetoacetate (AcAc) and ꞵ-hydroxybutyrate (ꞵOHB) from fatty ...