Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy [0.03%]
反复应用被动机械应力产生人类骨骼肌的选择性代谢和细胞外基质适应但不能防止失用性萎缩
Mohadeseh Ahmadi,Charles Seaman,Erik D Marchant et al.
Mohadeseh Ahmadi et al.
Exposure to mechanical stimuli can modulate skeletal muscle structure and metabolism, yet the extent to which repeated, isolated mechanical stress promotes adaptive remodeling in humans has not been defined. We investigated whether repeated...
An 'old' cytokine's new trick: IL-1β in B cells and the germinal center [0.03%]
一个“老”细胞因子的新把戏：B细胞和生发中心中的IL-1β
Juliana Restrepo Munera,Elise Rizzi,S Rameeza Allie
Juliana Restrepo Munera
IL-1β is typically associated with the innate response, often produced following the detection of pathogen associated-molecular patterns (PAMPs) and damage- associated molecular patterns (DAMPs). It is also identified as a cytokine involve...
Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction [0.03%]
内皮细胞中ADAM17介导的CD44剪切会损害剪切应力机械转导功能
Gavin Power,Min Jeong Cho,Jesus H Beltran-Ornelas et al.
Gavin Power et al.
In individuals with type 2 diabetes (T2D), blood flow-mediated increases in endothelial shear stress fail to elicit a robust vasodilatory response. This defective flow-mediated dilation (FMD) is associated with loss of the endothelial glyco...
Malgorzata Kasztan,Patrick A Molina,Brandon M Fox et al.
Malgorzata Kasztan et al.
Sickle cell nephropathy (SCN) significantly shortens the life expectancy of patients with sickle cell disease (SCD). We previously reported that endothelin-1 (ET-1) and endothelin A receptor (ETA) are up-regulated in SCN, and ETA antagonism...
The systems that transport ions and their impact on sperm function and male fertility [0.03%]
离子转运系统及其对精子功能和男性生育力的影响
Mumtarin Jannat Oishee,Beth Baum,Gustavo Blanco
Mumtarin Jannat Oishee
The cellular biology of macrophages underpins the multitude of roles that these cells undertake under homeostatic and inflammatory conditions. Macrophages populate all tissues where they contribute to organ physiology while acting as sensor...
Dietary Salt Impairs Circadian Physiological Metabolic Adaptations in Salt-Sensitive Hypertension [0.03%]
高盐饮食损害盐敏感性高血压的生理代谢节律适应
Lashodya V Dissanayake,Adrian Zietara,Ratnakar Tiwari et al.
Lashodya V Dissanayake et al.
The body's circadian rhythm is coordinated by core clock proteins (PER, CRY, CLOCK, and BMAL1) that function in both the central hypothalamic and peripheral tissue molecular clocks. Our recent study demonstrated that deletion of Per1 in Dah...
Epigenetic modifications of VEGF, cerebral hypoxia and impaired cerebrovascular autoregulation as early indicators for preterm brain injury [0.03%]
血管内皮生长因子表观遗传修饰、脑缺氧及自主调节受损在早产儿脑损伤中的早期指示作用
C L Brunsch,D H Klerk,D Blommaert et al.
C L Brunsch et al.
Neurodevelopmental impairments after preterm birth remain prevalent. Preterm brain injury, such as intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), occurs due to immature vascularization and impaired cerebral blood ...
Luisa Martinez-Pomares
Luisa Martinez-Pomares
The cellular biology of macrophages underpins the multitude of roles that these cells undertake under homeostatic and inflammatory conditions. Macrophages populate all tissues where they contribute to organ physiology while acting as sensor...
Mustafa Abdellatif,Jyotirmoy Rajurkar,Heinrich Leonhardt
Mustafa Abdellatif
Nanobodies, also known as single-domain antibodies, have become powerful tools in research, diagnosis and therapy. Sourced from the heavy chain of camelid Heavy chain-only antibodies, this domain retains many important characteristics of fu...
Short-term time-restricted feeding improves metabolic rhythms and liver mitochondrial bioenergetic function in high fat diet-fed mice [0.03%]
短期限食改善高脂饮食小鼠的代谢节律和肝脏线粒体生物能功能
Jennifer A Valcin,Telisha Millender-Swain,Jodi R Paul et al.
Jennifer A Valcin et al.
Time-restricted feeding (TRF), which confines food intake to specific time periods without altering nutrient content or reducing calories, has shown promise in improving cardiometabolic health. This study tested whether a two-week TRF inter...