Type 1 Diabetes Differentially Disrupts Right and Left Ventricular Daily Rhythms [0.03%]
1型糖尿病差异化破坏右心室和左心室的日常节奏
Sharanya S Bettadapura,Samantha J Torres,Marjie P Schmitt et al.
Sharanya S Bettadapura et al.
Circadian rhythms are endogenous ∼24-hour cycles that regulate cardiovascular physiology. While circadian regulation of the left ventricle (LV) is well established, whether the right ventricle (RV) exhibits intrinsic rhythmicity is not kno...
Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance [0.03%]
骨骼肌组成型mTORC1激活增加炎症但不会损害葡萄糖耐量
Erik D Marchant,Hanna Kalenta,Sean P Kilroe et al.
Erik D Marchant et al.
Aberrant mechanistic target of rapamycin complex 1 (mTORC1) signaling in skeletal muscle has been implicated in aging and insulin resistance, however, it is not known whether chronic mTORC1 activation directly causes glucose intolerance. We...
Ampakine-Hypoxia pairing reveals a novel NMDA-dependent respiratory neuroplasticity [0.03%]
氨甲酰肽激元-低氧配对揭示了一种新颖的NMDA依赖性呼吸神经可塑性
Pauline Michel-Flutot,Kun-Ze Lee,Stéphane Vinit
Pauline Michel-Flutot
Pairing ampakine with brief hypoxia evokes phrenic neuroplasticity via a spinal NMDA receptor mediated mechanism [0.03%]
通过脊髓NMDA受体介导的机制使氨甲酰胺与短暂缺氧相结合产生膈神经可塑性
Prajwal P Thakre,Sabhya Rana,Raphael R Perim et al.
Prajwal P Thakre et al.
Brief hypoxic episodes drive neuroplasticity in animal models and humans. Pretreatment with an allosteric AMPA receptor (R) modulator ("ampakine") enables a single hypoxic exposure to induce sustained increases in phrenic motor activity ("p...
Alcohol and calorie-dense diets modulate immune phenotype and metabolic health in simian immunodeficiency virus infection [0.03%]
酒精和高热量饮食通过调节免疫表型影响猴免疫缺陷病毒感染的代谢健康状况
Liz Simon,Megan Mire,Patrick M McTernan et al.
Liz Simon et al.
Alcohol misuse and calorie dense diets, especially those rich in sugar and fat, independently increase comorbidity risk among people with HIV. The objective of this study was to define the combined effects of chronic binge alcohol administr...
Simulated shift work Schedules disrupts circadian rhythms and behavior in mice [0.03%]
模拟轮班工作日程会扰乱小鼠的生物钟和行为模式
Jun-Yi Duan,Xiao-Tong Huang,Ai-Yu Duan et al.
Jun-Yi Duan et al.
Shift work has become a major cause of circadian rhythm disruption in modern society. This study investigated the systemic consequences of shift schedules by subjecting mice to different light-dark (LD) cycles: non-24-hour cycles (rapidly r...
Synchronization of the 12-hour circatidal rhythm maintains the kidney through repeated cycles of warm reperfusion in the hibernating ground squirrel [0.03%]
12小时半日夜节律通过地松鼠冬眠时肾脏的反复温复灌维持肾功能
Austin E Gillen,David J Orlicky,Rui Fu et al.
Austin E Gillen et al.
The hibernating 13-lined ground squirrel kidney is a unique natural model of resistance to damage caused by cold storage and warm reperfusion. Over months, the kidney is exposed to cycles between multi-day periods of torpor with low perfusi...
A clear view at altitude: layer-specific control of the choroidal circulation [0.03%]
高海拔清晰视界：脉络膜循环分层控制
Jui-Lin Fan,Philip R K Turnbull
Jui-Lin Fan
Cellular Senescence Links Muscle Atrophy and Posttraumatic Osteoarthritis after ACL Injury [0.03%]
半月板损伤后细胞衰老与肌肉萎缩和创伤性骨关节炎之间的联系
Alexander R Keeble,Allison Owen,Sara Gonzalez-Velez et al.
Alexander R Keeble et al.
Traumatic knee injury leads to posttraumatic osteoarthritis (PTOA) and significant skeletal muscle weakness, resulting in chronic disability. The current standard of care frequently fails to prevent musculoskeletal dysfunction, underscoring...
Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats [0.03%]
circadian钟蛋白Bmal1通过调节雄性大鼠呼吸运动的可塑性来调控呼吸功能
Aaron A Jones,Alexandria Beverly Marciante,Pierce Berardi et al.
Aaron A Jones et al.
Acute intermittent hypoxia (AIH) elicits respiratory motor plasticity in the phrenic, intercostal, and hypoglossal motor pools, and has emerged as a promising therapeutic strategy to improve respiratory function in people with neuromuscular...