Biology: Motion is Function [0.03%]
生物学：运动即功能
Lauren Gerard Koch,Steven L Britton
Lauren Gerard Koch
In 1966 Francis Crick declared that: "The ultimate aim of the modern movement in biology is to explain all biology in terms of physics and chemistry." This motivated us to contemplate approaches that unify biology at a fundamental level. Ex...
How do Adverse Childhood Experiences get Under the Skin to Promote Cardiovascular Disease? A Focus on Vascular Health [0.03%]
儿童不良经历如何影响心血管疾病？血管健康角度出发
Nathaniel D M Jenkins,Austin T Robinson
Nathaniel D M Jenkins
Mingyu Liang,Allen W Cowley Jr,Andrew S Greene et al.
Mingyu Liang et al.
The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature [0.03%]
童年逆境与心血管疾病风险之间的联系：脑血管和全身血管的作用
Paula Rodriguez-Miguelez,Jacob Looney,Marsha Blackburn et al.
Paula Rodriguez-Miguelez et al.
Adverse childhood experiences (ACEs) are traumatic events during the first years of life that are associated with a higher risk of developing cardiovascular disease (CVD) during adulthood. The medial prefrontal cortex (mPFC) is a core regio...
Multimodality Deep Phenotyping Methods to Assess Mechanisms of Poor Right Ventricular-Pulmonary Artery Coupling [0.03%]
多模态深度表型分析方法评估不良右心室-肺动脉耦合机制的发病机制
Farhan Raza,Callyn Kozitza,Chris Lechuga et al.
Farhan Raza et al.
Deep phenotyping of pulmonary hypertension (PH) with multimodal diagnostic exercise interventions can lead to early focused therapeutic interventions. Herein, we report methods to simultaneously assess pulmonary impedance, differential bive...
Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise [0.03%]
晚年自愿同时运动的肌肉特异性细胞和分子适应性反应
Cory M Dungan,Camille R Brightwell,Yuan Wen et al.
Cory M Dungan et al.
Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume enduranc...
Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7 [0.03%]
心肌细胞β肾上腺素能激活的亚细胞钙转运涉及内部β受体和AKAP7
Thomas R Shannon,Dan J Bare,Sabine Van Dijk et al.
Thomas R Shannon et al.
β-adrenergic receptor (β-AR) signaling in cardiac myocytes is central to cardiac function, but spatiotemporal activation within myocytes is unresolved. In rabbit ventricular myocytes, β-AR agonists or high extracellular [Ca] were applied...
Setting the Record Straight: A New Twist on the Chemiosmotic Mechanism of Oxidative Phosphorylation [0.03%]
拨乱反正：氧化磷酸化化学渗透机制的新观点
Magdalena Juhaszova,Evgeny Kobrinsky,Dmitry B Zorov et al.
Magdalena Juhaszova et al.
Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension [0.03%]
内皮Cul3突变损害一氧化氮介导的血管舒张并促进盐诱导的高血压
Jing Wu,Shi Fang,Ko-Ting Lu et al.
Jing Wu et al.
Human hypertension caused by in-frame deletion of CULLIN3 exon-9 (Cul3∆9) is driven by renal and vascular mechanisms. We bred conditionally activatable Cul3∆9 transgenic mice with tamoxifen-inducible Tie2-CREERT2 mice to test the importan...
ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement [0.03%]
ADAM17介导电压门控钙通道辅助α2δ亚基的蛋白酶体成熟并增强钙电流
Ivan Kadurin,Shehrazade Dahimene,Karen M Page et al.
Ivan Kadurin et al.
The auxiliary α2δ subunits of voltage-gated calcium (CaV) channels are key to augmenting expression and function of CaV1 and CaV2 channels, and are also important drug targets in several therapeutic areas, including neuropathic pain. The ...