Context-dependent immunomodulation by caspofungin: inflammatory attenuation involving spleen tyrosine kinase signaling in monocytic-cell systems versus pathogen-mediated immune amplification [0.03%]
卡波芬净的上下文依赖性免疫调节作用：脾酪氨酸激酶在单核细胞系统中的抗炎反应及病原体介导的免疫放大作用
Kazuhiro Itoh,Hiromichi Iwasaki,Masamichi Ikawa et al.
Kazuhiro Itoh et al.
The CRISPR/Cas-associated scaRNA modulates efeUOB expression and stress responses in Neisseria meningitidis [0.03%]
CRISPR/Cas相关的scaRNA调节脑膜炎奈瑟氏球菌efeUOB的表达及应激反应
Denise Pytlik,Milan Gerovac,Thorsten Bischler et al.
Denise Pytlik et al.
Neisseria meningitidis is a human-adapted commensal pathogen that must continuously balance nutrient acquisition with stress tolerance. Here, we identify a type II-C CRISPR/Cas-associated small RNA (scaRNA) as a posttranscriptional regulato...
Editorial: creative CRISPR-Cas: RNA-guided functions in defence and beyond [0.03%]
述评：创“ crispr-cas”：以 rna 为向导的功能在防御及其他方面
Wolfgang R Hess,Anita Marchfelder,Lennart Randau
Wolfgang R Hess
Editorial
microLife. 2026 Jul 11:7:uqag026. DOI:10.1093/femsml/uqag026 2026
Genome-scale metabolic modelling of the priority fungal pathogen Lichtheimia corymbifera [0.03%]
里特海姆氏念珠菌的全基因组代谢模型构建
Wassili Dimitriew,Jaime David Acosta Espana,Thomas Krüger et al.
Wassili Dimitriew et al.
Fungi harbor unique primary and secondary metabolic pathways that represent a hidden treasure of biochemical and natural compounds. Their metabolism is central to their ability to interact with, to adapt to and to survive in host environmen...
Divergent chemotactic sensing in Acanthamoeba reveals ligand-promiscuous, threshold-tuned pattern recognition without canonical formyl peptide receptors [0.03%]
揭示表型多态性的非常规趋化识别：无典型肽受体的配基容许及阈值调控模式识别
Viktor Hermaraj,Brendan W Wren,Fauzy Nasher
Viktor Hermaraj
Chemotaxis, the directed movement of an organism towards nutrients or away from noxious agents is a fundamental process for the survival of many micro-organisms. We combined high-resolution imaging, microfluidic gradients, and frame-by-fram...
Interferon-stimulated gene 15 expression negatively regulates resistance to Candida albicans infection in vulvovaginal epithelial cells [0.03%]
干扰素刺激基因15通过负向调控抗白色念珠菌固有免疫反应促进外阴阴道念珠菌病发生发展
Jördis V Schuchardt,Alexis Urtecho Valverde,Beatriz Cristóvão et al.
Jördis V Schuchardt et al.
Vulvovaginal candidiasis (VVC) is one of the most common fungal infections, affecting most women during their reproductive years. A core characteristic of VVC is the interplay between Candida albicans pathogenicity and dysregulated innate i...
Predicted bacterial uRBSs reveal translational coupling and ribosome-mediated RBS occlusion as gene-controlling mechanisms [0.03%]
预测的细菌uRBS揭示了作为基因控制机制的翻译偶联和由核糖体介导的RBS遮蔽现象
Theresa Dietz,Julian M Hahnfeld,Sophie Neumann et al.
Theresa Dietz et al.
Upstream open reading frames (uORFs) in the 5' leader of bacterial mRNAs can modulate gene expression, yet genome-wide identification remains limited. We combined bioinformatic prediction of ribosome-binding sites (RBSs)-a Shine-Dalgarno se...
Correction to: Salmonella relies on siderophore exploitation at low pH [0.03%]
Correction to: 低pH条件下鼠伤寒沙门氏菌依赖色氨酸类似物铁载体摄铁生长
[This corrects the article DOI: 10.1093/femsml/uqaf041.]. © The Author(s) 2026. Published by Oxford University Press on behalf of FEMS.
Published Erratum
microLife. 2026 Jun 22:7:uqag022. DOI:10.1093/femsml/uqag022 2026
A Chryseobacterium massiliae pore-forming MACPF domain protein mediates intra and interspecies competition against Bacteroides [0.03%]
一株黄杆菌属的多物种抗性孔形成蛋白介导对拟杆菌属的种内和种间竞争作用
Bianca Audrain,David Perez-Pascual,Stanislas Thiriet-Rupert et al.
Bianca Audrain et al.
Microbiota play crucial roles in host health, including protection against pathogens through competitive interactions between commensal and pathogenic bacteria that are mediated by direct contact or secreted factors. We previously demonstra...
Comparative proteome analyses of human natural killer cells from patients after allogeneic stem cell transplantation and healthy individuals challenged with Aspergillus fumigatus [0.03%]
人同种异体干细胞移植患者和健康受试者吸入烟曲霉后的自然杀伤细胞蛋白质组分析
Jan Springer,Matthias Drobny,Linda Heilig et al.
Jan Springer et al.
Natural killer (NK) cells contribute to the innate immune system and are pivotal for the defence against opportunistic pathogens, including fungi. Aspergillus fumigatus (AF), a filamentous mold, can cause invasive pulmonary aspergillosis in...