Vincent Herbreteau,Mathieu Picardeau
Vincent Herbreteau
Climate change is increasingly recognized as a key driver in the emergence and re-emergence of infectious diseases, including leptospirosis, a globally distributed bacterial zoonosis. The bacterial agents of leptospirosis infect humans thro...
A novel expression system for imaging single-molecule fluorescence in Haloferax volcanii WR806 enables visualization of altered Cas1 dynamics during UV-induced DNA damage response [0.03%]
Paula R Schrage,Uliana Afonina,Julia Wörtz et al.
Paula R Schrage et al.
Fluorescence microscopy has become an indispensable tool in biological research, offering powerful approaches to study protein dynamics and cellular processes in vivo. Among archaea, Haloferax volcanii has emerged as a particularly well-sui...
Living together: evolutionary and ecological dimensions of protist endosymbiosis [0.03%]
共生共存：原生动物内共生的生态和进化维度
Anna Karnkowska,Iván García-Cunchillos,Marta Sałek
Anna Karnkowska
Protists, which comprise the majority of eukaryotic diversity, frequently engage in endosymbiotic relationships with other unicellular eukaryotes or prokaryotes. These interactions have profoundly shaped eukaryotic evolution, not only throu...
FungiNetDB: a uniform (pre-)processing platform for fungal expression data [0.03%]
真菌表达数据的统一(预)处理平台FungiNetDB
Sascha Schäuble,Daniela Albrecht-Eckardt,Gianni Panagiotou
Sascha Schäuble
Fungi, and particularly fungal pathogens, are having an increasing impact on human health and economy. At the same time, modern high-throughput technologies offer insights deep into the molecular level and thus mechanisms, giving scientists...
Spatial proteomics for the analysis of host-pathogen interactions in mice lungs infected with Aspergillus fumigatus [0.03%]
小鼠肺脏感染烟曲霉菌的宿主病原菌互作的空间蛋白质组分析
Saskia Wolter,Thomas Krüger,Daniela Pelzel et al.
Saskia Wolter et al.
Understanding host-pathogen interactions at the molecular level requires methods capable of linking spatial context with proteomic information. Here, we present an integrated workflow combining matrix-assisted laser desorption/ionization ma...
Fragile research systems, brain drain, and predatory publishing in under-resourced countries [0.03%]
研究体系脆弱、人才流失和掠夺性出版在资源匮乏的国家中的问题
Stipan Jonjić,Zeynep Ceren Karahan,Puri Lopez-Garcia et al.
Stipan Jonjić et al.
Many countries with lower research & innovation capacity face persistent constraints in building stable research systems. Chronic underfunding and weak science policy reduce institutional capacity and limit researchers' career prospects. Th...
Editorial
microLife. 2026 Mar 24:7:uqag011. DOI:10.1093/femsml/uqag011 2026
Crucial Gram-positive type IV secretion system protein TraF is a structural homolog of type VII secretion system protein EssB/YukC [0.03%]
关键的革兰氏阳性菌第四类分泌系统蛋白TraF是第VII类分泌系统蛋白EssB/YukC的结构同系物
Kirill Kuhlmann,Amrutha Stallinger,Claudia Michaelis et al.
Kirill Kuhlmann et al.
Type IV secretion systems (T4SS) are found in both monoderm and diderm bacteria. The broad-host-range conjugative plasmid pIP501 from Enterococcus faecalis harbors a T4SS encoding 15 tra genes responsible for the spread of antimicrobial res...
Advances in molecular tools for elucidating nucleic acid biology in fungal pathogens [0.03%]
用于阐明真菌病原体核酸生物学的分子工具的研究进展
Lukas Schrettenbrunner,Neshima Mavani,Slavica Janevska et al.
Lukas Schrettenbrunner et al.
Throughout the history of molecular biology, surprising advances have come from the study of all sorts of microbes. The first description of DNA polymerase came from the bacterial workhorse Escherichia coli, reverse transcriptase was reveal...
Transmembrane effector substrates of type IV secretion systems: mechanisms of secretion and insertion into host cell membranes [0.03%]
IV型分泌系统的跨膜效应底物：分泌与嵌入宿主细胞膜的机制
Sarah-Maria Trenz,Ann-Kathrin Kuwertz,Josua Carl et al.
Sarah-Maria Trenz et al.
Intracellular Gram-negative pathogens employ either type IVA or type IVB secretion systems (T4SSs) to translocate effector proteins into host cells, where they modulate cellular processes to facilitate infection and promote intracellular su...
A modular genetic toolbox for precise gene regulation and multi-color imaging in streptococci [0.03%]
用于链球菌精确基因调控和多色成像的模块化遗传工具箱
Johann Mignolet,Albane Schmid,Johan Staub et al.
Johann Mignolet et al.
Fluorescent labeling is a powerful tool in microbiology allowing live cell imaging and providing insights into dynamic cellular processes, quantification of gene expression, and protein subcellular localization. Although multicolor imaging ...