Biochemical characterization of Bifidobacterium bifidum peptidoglycan d,l-endopeptidase BbMep that generates NOD2 ligands [0.03%]
枯草杆菌肽双歧杆菌BbMep（d,l-ends肽酶）的生化表征可生成NOD2配体
Jeric Mun Chung Kwan,Shiliu Feng,Evan Wei Long Ng et al.
Jeric Mun Chung Kwan et al.
Soluble peptidoglycan fragments produced by the gut bacteria are key effectors in microbiota-host crosstalk. Here, we biochemically characterized BbMep, an NlpC/p60 domain-containing peptidoglycan d,l-endopeptidase from Bifidobacterium bifi...
trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity [0.03%]
通过未修改的纳米抗体连接的包含交联型环辛烯(IL-1β免疫细胞因子)的细胞因子活性的“点击-2-释放”控制体系
Amber Barendrecht,Heleen H C Peeters,Diana Torres-García et al.
Amber Barendrecht et al.
Immunocytokines have emerged as a promising modality in cancer therapy, capitalizing on the precision of antibodies to deliver cytokines selectively to tumours. Yet, the toxicity of the cytokine portion of these antibody-cytokine constructs...
Hyunyong Kim,Yunha Hwang,Jin Sung Cheong et al.
Hyunyong Kim et al.
Zinc finger (ZF) proteins regulate transcription by interacting with cis-acting elements for gene expression in response to stimuli within physiological systems. Bioinformatic studies have proposed that zinc finger and BTB (Broad complex, T...
Dehydroglutathione, a glutathione derivative to introduce non-reversible glutathionylation [0.03%]
脱氢型谷胱甘肽：一种可引入非可逆型谷胱甘肽化的化合物
Daniel Oppong,Rayavarapu Padmavathi,Dhanushika S K Kukulage et al.
Daniel Oppong et al.
Protein cysteine is susceptible to diverse oxidations, including disulfide, S-sulfenylation, S-nitrosylation, and S-glutathionylation, that regulate many biological processes in physiology and diseases. Despite evidence supporting distinct ...
Halogenation of nucleic acid structures: from chemical biology to supramolecular chemistry [0.03%]
从化学生物学到超分子化学的核酸结构卤化作用
Catalina Nicolau,Julia Requena-Ramírez,Jorge González-García et al.
Catalina Nicolau et al.
Halogenation of organic molecules is a widespread resource used in the fields of chemical biology and rational drug design to improve the binding affinity or solubility of a given compound. Interestingly, the incorporation of Br and I in DN...
Contributors to the RSC Chemical Biology Emerging Investigators Collection 2024 [0.03%]
RSC化学生物学新兴 investigators 集合2024贡献者
This article profiles the early career researchers whose work features in the RSC Chemical Biology Emerging Investigators Collection 2024. This journal i...
An iridium(iii) 3-chloro-6-thio-1,2,4,5-tetrazine complex for cysteine conjugation, bioimaging and photoactivated therapy [0.03%]
用于半胱氨酸结合、生物成像和光激活治疗的铱(III) 3-氯-6-硫-1,2,4,5-四氮杂苯配合物
Lili Huang,Justin Shum,Lawrence Cho-Cheung Lee et al.
Lili Huang et al.
Photoactivatable systems have received considerable attention in the development of diagnostics and therapeutics due to their noninvasive nature and precise spatiotemporal control. Of particular interest is the 3,6-dithio-1,2,4,5-tetrazine ...
A state-of-the-art view: G-quadruplex-targeting for platinum complexes' treatment of tumors [0.03%]
铂类化合物治疗肿瘤的最新进展：以G-四链体为靶点
Jinrong Yang,Yu Chen,Hui Chao
Jinrong Yang
Cisplatin and its analogs are extensively utilized as metal-based anticancer agents in clinical settings due to their mechanism of action, which involves targeting genomic double-stranded DNA to induce cytotoxicity in cancer cells. However,...
A general and accessible approach to enrichment and characterisation of natural anti-Neu5Gc antibodies from human samples [0.03%]
一种通用且易于获取的方法，用于从人类样本中丰富和表征天然抗Neu5Gc抗体
Esme Hutton,Yumiko Uno,Emma Scott et al.
Esme Hutton et al.
N-Glycolylneuraminic acid (Neu5Gc) is a non-human sialic acid which is presented on the surface of human cells following uptake from dietary sources. Antibodies against Neu5Gc have implications for many aspects of human health such as infla...
Exploring substitution effects on the potential dominant conformations of NBF derivatives leading to functional conversion at the mu opioid receptor [0.03%]
探讨NBF衍生物置换效应及其对μ型阿片受体主位构象影响导致的功能转换现象
Ennian Li,Ahmed Reda,Hongguang Ma et al.
Ennian Li et al.
We previously identified NBF (β-configuration at C6) and its 6α-counterpart as mu opioid receptor (MOR) antagonists. To explore the effect of C6 conformation of the epoxymorphinan ring on their MOR function, five pairs of NBF derivatives ...