Michelle Marie B Helmeke,Rhianna L Haynie-Cion,Matthew R Pratt
Michelle Marie B Helmeke
Metabolic oligosaccharide engineering (MOE) is a transformative technology, enabling the chemical labeling and subsequent analysis of glycans. Central to this method are monosaccharide analogs, termed metabolic chemical reporters (MCRs), th...
Development of a silicon phthalocyanine analogue for near-infrared photoimmunotherapy and its application to HTLV-1-infected leukemic cells [0.03%]
一种近红外光免疫治疗的硅酞菁类似物及其在HTLV-1感染白血病细胞中的应用
Yoshikazu Fuse,Eita Sasaki,Masaharu Tamaki et al.
Yoshikazu Fuse et al.
Near-infrared photoimmunotherapy (NIR-PIT) employing an antibody labeled with a silicon phthalocyanine dye, IR700, was approved as a minimally invasive treatment for unresectable recurrent head and neck cancer in Japan in 2020. However, fur...
Exploring the significance of palmitoylation using an artificial protein lipidation system [0.03%]
利用人工蛋白质脂化系统探索棕榈酰化的意义
Kazuki Uchida,Naofumi Shimokawa,Rie Wakabayashi et al.
Kazuki Uchida et al.
Protein lipidation, particularly palmitoylation (attachment of a 16-carbon fatty acid), regulates cellular behaviors by controlling protein function at lipid membranes. In this study, we prepared a series of lipidated green fluorescent prot...
The impact of conjugation strategies and linker density on the performance of the Spermine-AcDex nanoparticle-splenocyte conjugate [0.03%]
连接策略和接头密度对Spermine-AcDex纳米颗粒-脾细胞偶联物性能的影响
Yuchen Su,Ruoyu Cheng,Bowei Du et al.
Yuchen Su et al.
A common approach in living medicine engineering is modifying cell surfaces with nanomedicines to form nanoparticle-cell conjugates. Despite various available strategies, limited research has examined how conjugation strategies affect the e...
Translocation of penetratin-like peptides involving calcium-dependent interactions between glycosaminoglycans and phosphocholine headgroups of the membrane lipid bilayer [0.03%]
涉及甘露糖氨基聚糖与膜脂双层磷胆碱头部集团的钙依赖性相互作用的穿膜肽类穿膜转运
Bingwei He,Sonia Khemaissa,Sébastien Cardon et al.
Bingwei He et al.
Cell-penetrating peptides (CPPs) can internalize ubiquitously in cells. To explore the specific targeting issue of CPPs, we used glycosaminoglycan (GAG)-binding peptides previously identified in Otx2 and En2 homeoproteins (HPs). The Otx2 se...
Photoactivatable and photolabile pharmacophores: lessons learned from capsaicin [0.03%]
光激活和光不稳定的药效基团：来自辣椒素的启示
Nils Imse,Lucia Rojas,Cristina Gil Herrero et al.
Nils Imse et al.
Light-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable (de)activation of small molecules is attractive both to study mo...
Unravelling structure-function interactions between fluorinated heparan sulfate mimetics and signaling proteins [0.03%]
含氟硫酸肝素类似物与信号传导蛋白之间的结构-功能相互作用的探究
Virendrasinh Mahida,Rakesh Raigawali,Paula González et al.
Virendrasinh Mahida et al.
Fluorinated carbohydrates are emerging scaffolds in glycobiology, enabling the elucidation of the roles of the individual hydroxyl groups of a carbohydrate in protein binding and drug discovery. Herein, we report a divergent strategy to syn...
Ian Ford,Miranda Villanueva,Min Sub Lee et al.
Ian Ford et al.
Stimulator of interferon genes (STING) is an intracellular pattern recognition receptor that plays a key role in responding to cytosolic DNA and cyclic dinucleotides. STING activity is tightly regulated to avoid aberrant STING activity, exc...
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Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition [0.03%]
C1和C3处三唑基取代基的协同作用可使半乳糖具有高亲和力和选择性的抑4C抑制剂效应
Alexander Dahlqvist,Rob Marc Go,Chandan Kishor et al.
Alexander Dahlqvist et al.
Galectins are a family of carbohydrate-recognising proteins involved in regulation of cell adhesion and cell signaling, leading to roles in e.g. cancer progression, fibrosis, and ulcerative colitis. Glycomimetic galectin inhibitors based on...