Ahmed G Eissa,Lauren E Powell,Julia Gee et al.
Ahmed G Eissa et al.
Aromatase (CYP19A1) inhibitors are the mainstay therapeutics for the treatment of hormone dependant breast cancer, which accounts for approximately 70% of all breast cancer cases. However, increased resistance to the clinically used aromata...
QSAR, structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y12) antagonist [0.03%]
基于QSAR、结构的药效团模型及新型血小板ADP受体(P2Y12)拮抗剂的生物评估研究
Belal O Al-Najjar,Manal A Abbas,Obada A Sibai et al.
Belal O Al-Najjar et al.
P2Y12 has a key role in platelet aggregation and thrombus formation via an ADP-induced platelet activation mechanism. Recently, P2Y12 antagonists have become of great interest in the clinical management of antithrombotic therapy. In light o...
Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents [0.03%]
新的阿贾伦酸衍生物作为抗癌症药物的设计、合成和生物评价
Bruno M F Gonçalves,Vanessa I S Mendes,Samuel M Silvestre et al.
Bruno M F Gonçalves et al.
Arjunolic acid (AA) is a pentacyclic triterpenoid with promising anticancer properties. A series of novel AA derivatives containing a pentameric A-ring with an enal moiety, combined with additional modifications at C-28, were designed and p...
Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates [0.03%]
一类新的1,2,3-三唑衍生物抗寄生虫候选药物的研究范围拓展
Renzo Carlucci,Gabriel Di Gresia,María Gabriela Mediavilla et al.
Renzo Carlucci et al.
We have previously shown that prenyl and aliphatic triazoles are interesting motifs to prepare new chemical entities for antiparasitic and antituberculosis drug development. In this opportunity a new series of prenyl-1,2,3-triazoles were pr...
Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study [0.03%]
通过原位点击化学、噬菌体展示和合成肽文库法识别特定碳酸酐酶抑制剂：方法比较及结构研究
Michael Kugler,Martin Hadzima,Rastislav Dzijak et al.
Michael Kugler et al.
The development of highly active and selective enzyme inhibitors is one of the priorities of medicinal chemistry. Typically, various high-throughput screening methods are used to find lead compounds from a large pool of synthetic compounds,...
Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores [0.03%]
用于识别蛋白质活性位点及其最小作用模式的碎片筛选库
Rebecca L Whitehouse,Wesam S Alwan,Olga V Ilyichova et al.
Rebecca L Whitehouse et al.
Fragment-based drug design relies heavily on structural information for the elaboration and optimisation of hits. The ability to identify neighbouring binding hot spots, energetically favourable interactions and conserved binding motifs in ...
Discovery of N-sulfonylated aminosalicylic acids as dual MCL-1/BCL-xL inhibitors [0.03%]
氨基水杨酸N-磺胺类衍生物作为MCL-1/BCL-xL双靶点抑制剂的研究
Lijia Chen,Jay Chauhan,Jeremy L Yap et al.
Lijia Chen et al.
The anti-apoptotic protein MCL-1, which is overexpressed in multiple cancers, is presently a focus for the development of targeted drugs in oncology. We previously discovered inhibitors of MCL-1 based on 1-sulfonylated 1,2,3,4-tetrahydroqui...
Design, synthesis and biological evaluation of pyrazolo[3,4- b]pyridine derivatives as TRK inhibitors [0.03%]
作为TRK抑制剂的吡唑并[3,4-b].py啶衍生物的设计、合成及生物学评价
Nian Liu,Xin Wang,Qinglin Fu et al.
Nian Liu et al.
Tropomyosin receptor kinases (TRKs) are associated with the proliferation and differentiation of cells, and thus their continuous activation and overexpression cause cancer. Herein, based on scaffold hopping and computer-aid drug design, 38...
Novel quinoline-piperazine hybrids: the design, synthesis and evaluation of antibacterial and antituberculosis properties [0.03%]
新型喹啉-哌嗪杂合物：抗菌及抗结核药物的设计、合成和评价
Karunanidhi Gnanavelu,Vinay Kumar K S,Sumesh Eswaran et al.
Karunanidhi Gnanavelu et al.
A communicable disease such as tuberculosis (TB), which takes ∼10 million lives worldwide every year, is one of the major concerns for future generations. The intake of multiple antibiotics is increasing because of the emergence of multipl...
Design, synthesis and immunological evaluation of monophosphoryl lipid A derivatives as adjuvants for a RBD-hFc based SARS-CoV-2 vaccine [0.03%]
基于RBD-hFc的SARS-CoV-2疫苗用单磷酸利福胺衍生物佐剂的设计、合成及免疫学评价
Shiwei Su,Liqing Chen,Menglan Yang et al.
Shiwei Su et al.
Toll-like receptor 4 (TLR4) is a reliable target for the development of vaccine adjuvants. To identify novel TLR4 ligands with improved immunological properties for use as adjuvants for a RBD-hFc based SARS-CoV-2 vaccine, herein, natural E....