Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities [0.03%]
用于阿尔茨海默病治疗的吡唑啶酮和吡嗪二酮骨架的研究：具有抗淀粉样蛋白β、抗tau、抗氧化和神经保护作用的COX-2多靶点抑制剂
Michael Emad,Reham Waheed,Zeinab Mostafa et al.
Michael Emad et al.
COX-2 enzyme is implicated in Alzheimer's disease (AD) through amyloid beta (Aβ) accumulation, tau aggregation, and neuroinflammation. However, clinical outcomes of COX-2 inhibitors in AD have been inconsistent. This study explores a novel...
Synthesis and evaluation of nitroheterocyclic aromatic adamantane amides with trypanocidal activity. Part II [0.03%]
具有锥虫细胞毒活性的硝基杂环芳香金刚烷酰胺的合成与评价（二）
Angeliki-Sofia Foscolos,Richard L Atherton,Maria Billia et al.
Angeliki-Sofia Foscolos et al.
In this article, we report the design, synthesis, and biological evaluation of a new series of nitroheterocyclic aromatic adamantane amides targeting trypanosomes. These compounds feature diverse substituents on the adamantane scaffold, var...
Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development [0.03%]
氟代嘧啶5-羧酰胺类化合物作为潜在的MERTK靶向放射性配体开发工具用于18F-PET成像研究
Ramesh Mudududdla,Siu Wai Wong,Nghi Nguyen et al.
Ramesh Mudududdla et al.
MER tyrosine kinase (MERTK) is highly expressed on the protective and reparative phenotype of microglia, which is in response to neuroregeneration following the neuronal damage induced by multiple sclerosis (MS). A specific imaging tool, wh...
Peripheral tailoring of pentacene: developing next-generation organic sonosensitizers for cancer sonodynamic therapy [0.03%]
边缘官能化的pentacene：开发下一代有机声敏化剂用于癌症声动力治疗
Nan Han,Yu Zhang,Chunyuan Hou et al.
Nan Han et al.
Sonodynamic therapy (SDT) is an innovative, non-invasive, and effective method for cancer treatment. However, exploring sonosensitizers with high sonosensitivity and biosafety remains a significant challenge. Recent investigations have demo...
Design, synthesis, and structural elucidation of ethyl 2-amino-5-oxo-4-aryl-4 H-pyrano[3,2- c]quinoline-3-carboxylates as dual EGFR/HER-2 inhibitors endowed with antiproliferative activity [0.03%]
一类具有抗增殖活性的新型EGFR/HER-2双靶点抑制剂的设计、合成及结构鉴定
Lamya H Al-Wahaibi,Hesham A Abou-Zied,Aliaa M Mohassab et al.
Lamya H Al-Wahaibi et al.
A new series of quinoline-3-carboxylate derivatives 3a-k were developed as prospective dual inhibitors of EGFR and HER-2. Structural elucidation was accomplished via 1H NMR, 13C NMR, DEPT NMR, elemental analysis and mass spectrometry. The s...
Diversifying the triquinazine scaffold of a Janus kinase inhibitor [0.03%]
一种Janus激酶抑制剂的三喹唑啉支架结构的多样化
Kleni Mulliri,Kris Meier,Johanna-Dorothea Feuchter et al.
Kleni Mulliri et al.
The exploration of novel three-dimensional scaffolds remains essential for expanding chemical space and discovering new bioactive molecules. Here, we describe a robust synthetic strategy that enables modulation of Janus Kinase activity thro...
Novel pyrido[2,3- b][1,4]oxazine-based EGFR-TK inhibitors: rational design and synthesis of potent and selective agents targeting resistance mutations in non-small cell lung cancer [0.03%]
基于新型吡啶并[2,3-b][1,4]恶嗪的EGFR-TKI抑制剂：非小细胞肺癌抗药性突变的理性设计及选择性靶向强力作用剂的合成
Vaibhav B Yadav,Shailee V Tiwari,S Hemant Kumar et al.
Vaibhav B Yadav et al.
Several first-, second-, and third-generation EGFR-TKIs have proven effective as anti-cancer therapeutics. However, the rapid development of drug resistance and mutations continues to be a major challenge in EGFR-TKI therapy. Addressing bot...
Synthesis and evaluation of lupeol-derived triterpenic azines as potential neuroprotective agents [0.03%]
卢鹏醇衍生物三萜
Florencia A Musso,Natalia P Alza,Gabriela A Salvador et al.
Florencia A Musso et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and the accumulation of α-synuclein aggregates. Current treatments are primarily symptomatic, highlighting the...
Evaluating the FEP+ protocol for predicting binding affinity of congeneric ligands towards various soluble proteins [0.03%]
评估FEP +协议预测各种可溶性蛋白质的同系物配体结合亲和力的能力
Shashi Kumar Sampangin Venkatesh,Arpan Das,Naga Rajiv Lakkaniga
Shashi Kumar Sampangin Venkatesh
Generating libraries of congeneric series of compounds and development of structure-activity relationships (SAR) is a common practice among medicinal chemists. While various computational methods are available to guide scaffold optimization...
The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition [0.03%]
3,5-取代呫吨酮的结构要求决定了其选择性激活AMPK或抑制GSK3β的作用
Juliet E Strang,Daniel D Astridge,Caleb Chandler et al.
Juliet E Strang et al.
AMP-activated protein kinase (AMPK) acts as a central cellular sensor at the interface of metabolic and signaling networks, that supports cell survival in energetically unfavorable environments. Due to its role in the direct mediation of fa...