Discovery of N-sulfonylated aminosalicylic acids as dual MCL-1/BCL-xL inhibitors
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The anti-apoptotic protein MCL-1, which is overexpressed in multiple cancers, is presently a focus for the development of targeted drugs in oncology. We previously discovered inhibitors of MCL-1 based on 1-sulfonylated 1,2,3,4-tetrahydroquinoline-6-carboxylic ... ...
