Advancing inducible gene-inactivation systems to explore synthetic lethality [0.03%]
开发可诱导的基因失活系统以探索合成致死性
Ádám Tamás Sánta,Alexandra Gráf,Katalin Vincze-Kontár et al.
Ádám Tamás Sánta et al.
Synthetic lethality offers opportunities to identify therapeutic targets for cancer research, facilitating the development of targeted tumour therapy protocols. However, current gene knockout approaches may cause compensatory changes in cel...
Manipulating DNA repair and the DNA damage response to improve cancer therapy [0.03%]
操控DNA修复和DNA损伤应答以改进癌症治疗措施
Li Lan,Elise Fouquerel
Li Lan
Charting the multilevel molecular response to palbociclib in ER-positive breast cancer [0.03%]
palbociclib治疗阳性乳腺癌的多层次分子反应图表
Archishma Kavalipati,Amy Aponte,Michael E Sullivan et al.
Archishma Kavalipati et al.
The addition of CDK4/6 inhibitors to endocrine therapy has significantly improved outcomes in HR+/HER2- breast cancer (BC). However, variable patient responses and acquired resistance remain a clinical challenge. We therefore defined the co...
The RRM domains of PARP14 mediate replication fork degradation in BRCA2-deficient cells [0.03%]
PARP14的RRM结构域介导BRCA2缺陷细胞中复制叉降解
Anastasia Hale,Katie A Lynch,Ashna Dhoonmoon et al.
Anastasia Hale et al.
Degradation of reversed replication forks by nucleases has emerged as a major mechanism of chemosensitivity in BRCA-deficient cells. We previously showed that the mono-ADP-ribosyltransferase PARP14 regulates MRE11 recruitment to reversed re...
Identification of siRNA silencing TGFβ1 and VEGFR2 and utility of the combination in targeting immune modulation and angiogenesis in treating melanoma in vivo [0.03%]
用于治疗黑色素瘤的siRNA沉默TGFβ1和VEGFR2的鉴定及其联合使用在体内靶向免疫调节和血管生成中的应用
Deling Wang,Wanying Jia,Jinping Lian et al.
Deling Wang et al.
Late-stage melanoma can metastasize to organs beyond the skin, such as lungs, liver, brain, and bone, resulting in reduced patient survival time. The incidence of melanoma is currently growing worldwide, and novel therapeutic options are ne...
Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis in vivo [0.03%]
Rad18在体内抑制致癌物和癌基因驱动的突变的差异作用
Jay R Anand,Bethany Wagner Brown,Jitong Lou et al.
Jay R Anand et al.
The DNA repair protein RAD18 activates "Y-family" trans-lesion synthesis (TLS) DNA polymerases that are DNA damage-tolerant and potentially error-prone. RAD18 is also frequently overexpressed and pathologically activated in cancer cells. Ho...
Ribosome biogenesis is increased in hepatocellular carcinoma and represents a potential therapeutic target [0.03%]
核糖体生物发生增强是肝细胞癌的潜在治疗靶点
Sille Blangstrup Geisler,Kezia Catharina Oxe,Stavroula Boukoura et al.
Sille Blangstrup Geisler et al.
Globally, liver cancer is the sixth most prevalent cancer type and the third leading cause of cancer-related deaths, making the need for improved treatment evident. We conducted a pan-cancer tissue microarray analysis to identify cancer typ...
Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes [0.03%]
靶向性CRISPR敲除筛选鉴定出DNA损伤药物和DNA修复基因之间已知的和新的化学基因组相互作用
Collin D Heer,James L Elia,Vijay Menon et al.
Collin D Heer et al.
Genetic instability is a hallmark of cancer, often arising from mutations to DNA damage repair and response (DDR) genes. Classical genetic, biochemical, and structural approaches elucidated the foundational mechanisms of DDR pathways and pr...
Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis [0.03%]
由PRMT1/PRMT5/ATR轴调控的DNA复制相关的碱基切除修复/单链断裂修复调节PARG抑制剂响应
Md Ibrahim,Wynand P Roos,Jacob C Schwartz et al.
Md Ibrahim et al.
Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a post-translational protein modification, in response to DNA damage or replication stress. Here, ...
Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency [0.03%]
MLH1羧基末端结构域互作热点的破坏导致错配修复缺陷
Keri M Fishwick,Diego Gomez Vieito,Giada Greco et al.
Keri M Fishwick et al.
MutLα, a heterodimer of MLH1 and PMS2, plays a key role in DNA mismatch repair (MMR), which maintains genomic stability by correcting replication errors. Loss of MLH1 function causes MMR deficiency (MMRd), leading to elevated mutation rate...