Cross-modal mapping of cancer stem-like cell plasticity using deep learning [0.03%]
基于深度学习的癌症干细胞样细胞可塑性跨模式映射研究
Debojyoti Chowdhury,Shreyansh Priyadarshi,Sayan Biswas et al.
Debojyoti Chowdhury et al.
Cancer stem-like cells (CSCs) play a pivotal role in driving tumor heterogeneity, therapeutic resistance, and disease progression. Despite the power of single-cell RNA sequencing (scRNA-seq) to resolve intratumoral hierarchies, there remain...
Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer [0.03%]
持续的干扰素信号传导和克隆扩张标志着DNA甲基化损伤引起的肝癌早期事件
Lee J Pribyl,Jennifer E Kay,Joshua J Corrigan et al.
Lee J Pribyl et al.
N-Nitrosodimethylamine (NDMA), a probable human carcinogen, induces toxic and mutagenic DNA O 6-methylguanine (O 6MeG) adducts that are repaired by O 6-methylguanine-DNA methyltransferase (MGMT). To elucidate how early-life environmental mu...
Loss of CHTF18-RFC2/5 leads to replicative gaps and sensitivity to PARP inhibitors [0.03%]
CTHF18-RFC2/5丢失导致复制缺口和对聚ADP-核糖聚合酶抑制剂敏感性增加
Lauryn Buckley-Benbow,Meryem Ozgencil,Alessia Tardocchi et al.
Lauryn Buckley-Benbow et al.
The use of PARP inhibitors (PARPi) has profoundly changed the treatment of BRCA1/BRCA2-mutated cancers. Despite this, acquired resistance to PARPi has become a major challenge in the clinic. Hence, a more detailed understanding of the mecha...
Disruption of the structural maintenance of chromosomes 5/6 complex enables tumor mutagenesis [0.03%]
结构维护染色体5/6复合体的破坏可促进肿瘤突变生成
Thi Tran,Jiayi Fan,Xiaolan Zhao et al.
Thi Tran et al.
The structural maintenance of chromosomes (SMC) 5/6 complex is conserved and essential for mammalian development. SMC5/6 germline variants in cells, model organisms, and patients results in genome instability. However, the consequences of s...
Sensitive detection of somatic mutations in GC-rich cancer gene promoters [0.03%]
富鸟嘌呤和胞嘧啶的癌症基因启动子中体细胞性突变的敏感检测
Meifang Qi,Preshita Sanjay Dave,Nicole Francis et al.
Meifang Qi et al.
Somatic mutations in protein-coding genes and noncoding regulatory regions are the major drivers of cancer. Only a relatively small number of somatic noncoding mutations that are likely drivers have been described to date, including those i...
Tomoaki Fujii,Yukimi Sakoda,Kazuto Yoshimi et al.
Tomoaki Fujii et al.
The CRISPR-Cas9 system has been widely adopted as a genome editing tool due to its high efficiency and versatility, contributing to the development of various therapeutic strategies. However, its clinical application remains limited by safe...
Uncovering novel germline variants associated with testicular germ cell tumors by exome sequencing [0.03%]
通过外显子组测序发现与睾丸生殖细胞瘤相关的新型胚系变异
Berenice Cuevas-Estrada,Juan A Ríos-Rodríguez,José A García-Pacheco et al.
Berenice Cuevas-Estrada et al.
Testicular germ cell tumors (TGCT) are highly heritable malignancies that display increasing incidence worldwide, with rising mortality rates particularly evident among Hispanic men. However, genomic studies of TGCT have largely focused on ...
MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription [0.03%]
MYC和AP-1癌基因通过结合增强子来重塑转录程序
Reshma Kalyan Sundaram,Kshitiz Parihar,Stephanie Monson et al.
Reshma Kalyan Sundaram et al.
The transcription factor c-MYC (MYC) is deregulated in ~70% of human cancers. Through de novo motif discovery analysis on published MYC ChIP-seq datasets from cancer cell lines, we found cell-type-specific co-enrichment of the TRE motifs (A...
Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells [0.03%]
人DEAH盒解旋酶8通过介导HSF1介导的应激反应和肿瘤相关前信使核糖核酸剪接来调节癌症发展
Jennifer R Tall,Robert Te Poele,Alexandra Vasile et al.
Jennifer R Tall et al.
Transcription factor heat shock factor 1 (HSF1) orchestrates the cellular stress response, promoting malignant transformation, unchecked proliferation, and stress-resilient survival of tumour cells. We set out to discover potentially drugga...
Advancing inducible gene-inactivation systems to explore synthetic lethality [0.03%]
开发可诱导的基因失活系统以探索合成致死性
Ádám Tamás Sánta,Alexandra Gráf,Katalin Vincze-Kontár et al.
Ádám Tamás Sánta et al.
Synthetic lethality offers opportunities to identify therapeutic targets for cancer research, facilitating the development of targeted tumour therapy protocols. However, current gene knockout approaches may cause compensatory changes in cel...