A single-institution retrospective study of multicentric gliomas stratified by IDH mutational status [0.03%]
基于IDH突变状态的多中心胶质瘤单机构回顾性研究
Chuyin Yang,Ryan Mostafavi,Collin Le et al.
Chuyin Yang et al.
Background: Multicentric glioma (MCG) are defined radiographically as two or more tumor foci with separation of MRI T2-FLAIR (T2-weighted Fluid-attenuated Inversion Recovery) hyperintensities presenting synchronously (sMC...
Exploring relationships between abnormal within-network functional connectivity, preoperative brain tumor variables, and neuropsychological test scores [0.03%]
探究脑肿瘤患者的异常功能性连接与术前神经心理测验成绩的关系
Bryce J Laurin,Randall Treffy,Christina Feller et al.
Bryce J Laurin et al.
Objective: Neuropsychological symptoms in people with brain tumors are common; however, they are often incompletely explained by tumor variables (such as anatomical location, size, or grade) and may be more directly relat...
Clofoctol as a novel senolytic drug eliminating therapy-induced senescent glioma cells [0.03%]
氯氟醇作为一种新型的senolytic药物消除疗法诱导的衰老胶质瘤细胞
Yuxin Zhang,Zhixing Wang,Yue Wang et al.
Yuxin Zhang et al.
Background: Glioblastoma is the most common malignant brain glioma, accounting for ∼48% of malignant central nervous system tumors. Targeting glioma stem cells and senescent glioma cells represents promising therapeutic ...
Hemizygous deletion of CDKN2A/B in IDH-mutated glioma: Prognostic impact when adjusting for clinical factors [0.03%]
IDH突变型胶质瘤中CDKN2A/B单倍体缺失的临床意义：校正临床因素后的预后价值分析
Anna Lipatnikova,Franziska M Ippen,Anna Dénes et al.
Anna Lipatnikova et al.
Background: There is inconsistent evidence if hemizygous CDKN2A/B deletion affects survival in IDH-mutated glioma, and clinical characteristics are rarely accounted for. This study aims to investigate overall survival and...
Higher perioperative dexamethasone exposure is associated with shorter survival in glioblastoma [0.03%]
更高的围手术期丙酮酸氯化物暴露与胶质母细胞瘤患者的生存时间缩短有关
Severin Rüssli,Claire Descombes,Alexis P R Terrapon et al.
Severin Rüssli et al.
Background: Dexamethasone (DEX) is routinely administered perioperatively to manage tumor-associated vasogenic edema in glioblastoma (GBM), yet increasing evidence suggests that corticosteroid exposure may adversely affec...
Artificial intelligence in neuro-oncology: Current advances and legal considerations in the European Union [0.03%]
神经肿瘤学中的人工智能：欧洲联盟中的最新进展和法律考量
Sarina Agkatsev,Michael Templeton,Lazaros Lazaridis et al.
Sarina Agkatsev et al.
Applications utilizing artificial intelligence (AI) have become a ubiquitous, indispensable part of modern life. This also applies to medicine where AI systems can support staff in decision-making processes and administrative tasks, but the...
Brain tumor segmentation in Sub-Saharan Africa patient population: The BraTS-Africa challenge [0.03%]
非洲脑肿瘤分割：BraTS-Africa挑战赛
Maruf Adewole,Jeffrey D Rudie,Anu Gbadamosi et al.
Maruf Adewole et al.
Background: Automated brain tumor segmentation on multi-parametric magnetic resonance imaging (mpMRI) is crucial in assessing patient outcomes and remains a challenge across Sub-Saharan Africa (SSA). Since 2012, the Brain...
Spinal high-grade astrocytoma with piloid features arising in a patient with molecularly confirmed cerebellar pilocytic astrocytoma [0.03%]
伴有小脑毛细胞星形细胞瘤分子特征的脊髓 piloid 表型的高级别星形细胞瘤病例报告
Xiaoci Rong,Nan Chen,Yanghao Hou et al.
Xiaoci Rong et al.
Pilocytic astrocytoma (PA) is a benign tumor with a low risk of high-grade transformation. High-grade astrocytoma with piloid features (HGAP) is a recently recognized tumor entity that may arise de novo or from low-grade gliomas. Here, we r...
Patient preferences for incidental findings in a genomic trial: Insights from the Copenhagen glioblastoma cohort [0.03%]
基因组试验中患者对意外发现的偏好：哥本哈根胶质母细胞瘤队列中的启示
Anders Overby Sjøstrøm,Maria Camilla Mathiasen,Ulrik Lassen et al.
Anders Overby Sjøstrøm et al.
Glioblastoma (GBM) patients often face cognitive impairment, which may limit their capacity to comprehend complex trial information, particularly regarding genomic analyses and incidental findings. We analyzed consent forms from a genomic s...
Clinical characteristics and outcomes of adult IDH-mutant brainstem gliomas: Institutional case series and systematic review [0.03%]
IDH突变脑干胶质瘤的临床特征和预后：机构病例系列及系统综述
Maged T Ghoche,Kenji Miki,Fanen Yuan et al.
Maged T Ghoche et al.
Background: Adult IDH-mutant brainstem gliomas (BSGs) are rare and appear molecularly distinct from H3K27-altered diffuse midline gliomas. We aimed to provide a comprehensive characterization by integrating an institution...