Integrated detection of cerebrospinal fluid cfDNA/cfRNA and molecular concordance with glioma characteristics [0.03%]
Maoyuan Sun,Shan Jiang,Houshi Xu et al.
Maoyuan Sun et al.
Background: Accurate glioma diagnosis relies on tissue biopsy, which is often challenging. Liquid biopsy offers an alternative, but single-component circulating free DNA (cfDNA) or circulating free RNA (cfRNA) approaches ...
Clinical outcome of biomarker-guided therapies in adult neuro-oncology patients: An update from the Tübingen molecular tumor board cohort [0.03%]
David Rieger,Hannes Becker,Bianca Walter et al.
David Rieger et al.
Background: Molecular profiling and subsequent discussions in the Molecular Tumor Board (MTB) within the network of Centers for Personalized Medicine (CPM) have expanded therapeutic options for neuro-oncology patients. He...
Joshua D Strauss,Priya B Shetty,Spiridon Tsavachidis et al.
Joshua D Strauss et al.
Background: Ependymoma is a malignancy of the neuroepithelium-derived ependyma that lines the spinal cord and ventricles of the brain, occurring most frequently in young children and older adults. Genetic susceptibility t...
Durable disease control in a radiation-induced high-grade glioma harboring NF1 and PTPN11 co-mutations [0.03%]
Mohamed Sherief,Maria Fatteh,Jaime Wehr et al.
Mohamed Sherief et al.
Radiation-induced gliomas (RIGs) are rare and aggressive secondary brain tumors arising years after cranial irradiation. Their management remains challenging due to prior radiation exposure, which limits additional radiation, and a lack of ...
A systematic review and meta-analysis of outcomes following active surveillance, surgery and radiotherapy of meningiomas in NF2-related schwannomatosis [0.03%]
Jack Sheppard,Siddarth Kannan,Jane Halliday et al.
Jack Sheppard et al.
Background: Meningiomas affect up to 80% of patients with NF2-related schwannomatosis during their lifetime. They are managed by active monitoring, surgery, and stereotactic radiosurgery (SRS). This paper aims to synthesi...
Cecile Riviere-Cazaux,Yuta Suzuki,Zain Kizilbash et al.
Cecile Riviere-Cazaux et al.
Background: Imaging-based glioma monitoring is confounded by treatment-related changes. D-2-hydroxyglutarate (D-2-HG), produced by the isocitrate dehydrogenase (IDH) mutation, is detectable in cerebrospinal fluid (CSF), w...
The TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients [0.03%]
Pranjali P Kanvinde,Adarsha P Malla,Alexandra A Seas et al.
Pranjali P Kanvinde et al.
Background: Fibroblast growth factor-inducible 14 (Fn14) belongs to the TNFR superfamily. Fn14 overexpression can drive receptor-autonomous signaling, increase both cell invasion and tumor-associated macrophages/microglia...
Adult patient and caregiver perspectives on the impact of NF1-PN: Insights from a US qualitative survey [0.03%]
Phioanh L Nghiemphu,Conrad L Cordova,Alyssa Bowling et al.
Phioanh L Nghiemphu et al.
Background: Adults with neurofibromatosis type 1 and plexiform neurofibroma (NF1-PN) experience multiple clinical symptoms and diverse manifestations, which place a burden on patients and impact quality of life. This qual...
Real-world outcomes for selumetinib in pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas in Japan: A 1-year interim analysis [0.03%]
Yoshihiro Nishida,Akiyo Kitajima,Tomonori Ishii
Yoshihiro Nishida
Background: This postmarketing surveillance assessed the real-world safety and effectiveness of selumetinib in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN) in Japan. ...
Antiepileptic drugs in glioblastoma survival: dichotomic or treatment and mechanism of action-dependent variable? [0.03%]
Oktay Genel,Sultan Alzarouni,Asfand Baig Mirza et al.
Oktay Genel et al.
Background: Recent evidence has demonstrated a tight relationship between neuronal activity and glioblastoma (GBM) growth, involving novel mechanisms such as neuron-glioma synapses and tumor microtube networks. Seizure ac...