A clinical decision-support framework to differentiate radiation necrosis from tumor progression in brain metastases [0.03%]
一种临床决策支持框架用于鉴别脑转移瘤放疗后反应与肿瘤进展的区别
Beatriz Ocaña-Tienda,Zhao Hui Chen Zhou,Ana Ramos et al.
Beatriz Ocaña-Tienda et al.
Background: Differentiating radiation necrosis (RN) from tumor progression (TP) after stereotactic radiotherapy (SRT) in brain metastases (BMs) is a clinically consequential problem, as conventional MRI frequently fails t...
A clinical decision-support framework to differentiate radiation necrosis from tumor progression in brain metastases [0.03%]
一种临床决策支持框架用于鉴别脑转移瘤放疗后反应和肿瘤进展的区别
Beatriz Ocaña-Tienda,Zhao Hui Chen Zhou,Ana Ramos et al.
Beatriz Ocaña-Tienda et al.
Background: Differentiating radiation necrosis (RN) from tumor progression (TP) after stereotactic radiotherapy (SRT) in brain metastases (BMs) is a clinically consequential problem, as conventional MRI frequently fails t...
Spontaneous cellular senescence and stress response heterogeneity in human vestibular schwannomas [0.03%]
人前庭神经鞘瘤中的自发性细胞衰老和应激反应异质性
Sandra Franco-Caspueñas,Carmen Ruiz-García,Julio Contreras et al.
Sandra Franco-Caspueñas et al.
Background: Vestibular schwannomas (VS) are rare tumors of the eighth cranial nerve. Their complex etiology and not-well defined molecular basis prompted an investigation into cellular senescence as a contributing factor ...
A fluorescein-conjugated somatostatin receptor antagonist adapter for chimeric antigen receptor T cell therapy of meningioma [0.03%]
一种荧光素偶联生长抑素受体拮抗剂适配器，用于脑膜瘤的嵌合抗原受体T细胞治疗
Jiawei Chen,Christian Pellegrino,Maximilian Mastall et al.
Jiawei Chen et al.
Background: A significant proportion of meningiomas are resistant to current treatments. Somatostatin receptor 2 (SSTR2) is highly and consistently expressed in most meningiomas, providing a promising target for localized...
Phase I trial and pharmacokinetic study of berubicin (RTA 744) in patients with recurrent or refractory high-grade gliomas [0.03%]
用于治疗复发性或难治性高级别胶质瘤的伯瑞尤霉素（RTA 744）I期临床试验及药代动力学研究
Charles A Conrad,Sigmund H Hsu,Neil Thapar et al.
Charles A Conrad et al.
Background: This multi-institutional phase I trial aimed to determine the maximum tolerated dose (MTD), dose-limiting toxicities, pharmacokinetics, and preliminary antitumor activity of berubicin (WP744 or RTA744), design...
Intercellular adhesion molecule 1 links glioblastoma biology to a scalable prognostic model integrating clinical, imaging, and molecular features [0.03%]
细胞间粘附分子1将胶质母细胞瘤生物学与整合临床、影像和分子特征的可扩展预后模型联系起来
Shreya Gandhi,Beatriz Ocaña-Tienda,Manuel M Bettencourt et al.
Shreya Gandhi et al.
Background: Glioblastoma (GB) exhibits marked tumor microenvironmental heterogeneity, contributing to both therapy resistance and poor survival outcomes. Intercellular adhesion molecule 1 (ICAM1) is an inflammation-associ...
Targeting replication stress in glioblastoma: From genotoxic treatment and inhibitors of the DNA damage response to immunotherapy [0.03%]
靶向胶质母细胞瘤中的复制压力：从基因毒性治疗和DNA损伤反应抑制剂到免疫治疗
Alexandros Pailas,Ana Catarina Vales de Almeida,Miriam Torres-Fernández et al.
Alexandros Pailas et al.
Replication stress (RS) encompasses states of impaired DNA replication progression associated with fork slowing, stalling, or collapse. RS triggers a specialized branch of the DNA damage response (DDR) called the RS response (RSR) and const...
Intensive multimodal ketogenic metabolic therapy in glioblastoma: A clinical trial [0.03%]
胶质母细胞瘤的强化多模态酮体代谢治疗：一项临床试验
Matthew C L Phillips,Ziad Thotathil,Nur Azri Bin Haji Mohd Yasin et al.
Matthew C L Phillips et al.
Background: Glioblastoma (GBM), isocitrate dehydrogenase (IDH)-wildtype, has a median overall survival of 11-14 months despite standard treatment. Ketogenic metabolic interventions that lower the glucose ketone index (GKI...
Chromosomal instability is associated with paradoxical cGAS upregulation and impaired STING signaling shaping the immune microenvironment in glioblastoma [0.03%]
染色体不稳定性与cGAS反常上调及STING信号受损塑造胶质母细胞瘤免疫微环境相关
Hidenobu Yoshitake,Tetsuya Negoto,Mayuko Moritsubo et al.
Hidenobu Yoshitake et al.
Background: Glioblastoma (GBM) is characterized by pronounced chromosomal instability (CIN), which can activate the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway and promote anti-tumor immuni...
Malignant peripheral nerve sheath tumor development during MEK inhibitor treatment: A pre-clinical study and a clinical case series [0.03%]
在MEK抑制剂治疗过程中外周神经鞘恶性肿瘤的发展：一项临床前研究和病例系列研究
Andrea M Gross,Steven D Rhodes,Anne Dufek et al.
Andrea M Gross et al.
Background: People with Neurofibromatosis type 1 (NF1) are at risk of developing benign and malignant peripheral nerve sheath tumors (MPNST). In NF1, the overall lifetime risk of MPNST is estimated at 8%-13%, with increas...