Chromosomal instability is associated with paradoxical cGAS upregulation and impaired STING signaling shaping the immune microenvironment in glioblastoma
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Background: Glioblastoma (GBM) is characterized by pronounced chromosomal instability (CIN), which can activate the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway and promote anti-tumor immunity. How ... ...
