A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing [0.03%]
一个新的药物类水溶小分子黏着斑激酶(FAK)激活剂促进肠粘膜愈合
Qinggang Wang,Ricardo Gallardo-Macias,Emilie E Vomhof-DeKrey et al.
Qinggang Wang et al.
Non-steroidal anti-inflammatory drugs (NSAIDs) injure the proximal and distal gut by different mechanisms. While many drugs reduce gastrointestinal injury, no drug directly stimulates mucosal wound healing. Focal adhesion kinase (FAK), a no...
A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties [0.03%]
具有改善的细胞穿透和ROS靶向性能的新三苯基膦接枝两亲性阳离子肽
Rezeda A Ishkaeva,Diana V Salakhieva,Ruslan Garifullin et al.
Rezeda A Ishkaeva et al.
We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetrating and cytoprotective motif. TPP moiety was found to ...
Heme-heme oxygenase-2 reduces the atherosclerosis by preventing inflammation [0.03%]
血红素-血红素氧合酶-2通过防止炎症来减少动脉粥样硬化
Zhenzhen Wang,Xiaoqiang Zhan,Shuai Yang et al.
Zhenzhen Wang et al.
Objective: Heme oxygenase (HO) has been shown to have important antioxidant and anti-inflammatory properties, resulting in a vascular antitherogenic effect. This study was undertaken to evaluate the role of HO-2 in athero...
Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds [0.03%]
促炎细胞因子在阿尔茨海默氏症中的作用及聚乙二醇化自组装纳米支架的神保护效应
Varsha Rani,Rinki Verma,Krishan Kumar et al.
Varsha Rani et al.
Neurodegeneration and synaptic loss in Alzheimer's disease (AD) lead to impairment in memory functions. Neuroinflammation causes activation of microglia and astrocytes cells that locally and systemically produces inflammatory cytokines whic...
Myoinositol supplementation for the prevention of gestational diabetes in at-risk patients. Systematic review and meta-analysis [0.03%]
肌醇补充剂预防高危孕妇妊娠期糖尿病的系统评价和荟萃分析
Anthéa Bertrand,Denis Gallot,Bruno Pereira et al.
Anthéa Bertrand et al.
Background: Gestational diabetes (GD) is associated with an increase in maternal and fetal morbidity. The risk factors involved have been clearly identified but no prevention strategies have yet provided robust evidence o...
Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review [0.03%]
探索肿瘤对免疫检查点抑制剂反应的性别差异的遗传和免疫基础：一项叙述性回顾
Giulia Mazzaschi,Federico Quaini,Sebastiano Buti
Giulia Mazzaschi
Introduction: In spite of the undisputed relevance of sex as critical biologic variable of the immune landscape, still limited is our understanding of the basic mechanisms implicated in sex-biased immune response thereby ...
Recent developments on UDP-N-acetylmuramoyl-L-alanine-D-gutamate ligase (Mur D) enzyme for antimicrobial drug development: An emphasis on in-silico approaches [0.03%]
UDP-N-乙酰胞壁酰-L-丙氨酰-D-谷氨酸合成酶(Mur D)在抗菌药物开发中的最新进展：强调计算机模拟方法
Vinita Gaur,Surojit Bera
Vinita Gaur
Introduction: The rapid emergence of antibiotic resistance among various bacterial pathogens has been one of the major concerns of health organizations across the world. In this context, for the development of novel inhib...
4-Hydroxyisoleucine inhibits tumor growth by triggering endoplasmic reticulum stress and autophagy [0.03%]
4-羟基异亮氨酸通过触发内质网压力和自噬来抑制肿瘤生长
Peng Li,Yonghui Yang,Lu Qiu et al.
Peng Li et al.
4-Hydroxyisoleucine（4-HIL）is a non-protein amino acid that is able to reduce obesity and improve insulin sensitivity in mice, and recently emerged as a drug candidate against hypoglycemia. For the first time, we found that 4-HIL exhibits a po...
Rajib Majumder,Sanmitra Ghosh,Arpita Das et al.
Rajib Majumder et al.
ncRNA plays a very pivotal role in various biological activities ranging from gene regulation to controlling important developmental networks. It is imperative to note that this small molecule is not only present in all three domains of cel...
Saad Mustafa,Mahmood Akbar,Mohammad Aasif Khan et al.
Saad Mustafa et al.
Plant-derived flavonoids have been the focus of research for many years mainly in the last decade owing to their therapeutic properties. So far, about 4000 flavonoids have been identified from plants and diosmin (a flavone glycoside) is one...