Therapeutic potential, pharmacological role and molecular mechanisms of adelmidrol, an analogue of palmitoylethanolamide [0.03%]
棕榈酸乙醇胺类似物阿德米卓林的治疗潜力、药理作用和分子机制
Bushra Zia,Abdulrahman Alkaabi,Niraj Kumar Jha et al.
Bushra Zia et al.
Adelmidrol is a bioactive semi-synthetic compound with significant therapeutic potential, particularly in resolving inflammation since inflammation plays a key role in the pathogenesis of several diseases. The mechanisms of action of adelmi...
Breaking biofilm barriers in skin wounds: Membrane-Active antimicrobials in an era of resistance [0.03%]
突破皮肤伤口生物膜障碍：耐药时代的膜活性抗菌剂
Lisa Myrseth Hemmingsen,Nataša Škalko-Basnet
Lisa Myrseth Hemmingsen
Chronic wounds remain a significant challenge for healthcare systems worldwide, placing a considerable burden on both patients and resources. Their management is further complicated by the persistence of biofilm-forming bacteria and an esca...
Synergistic effect of oxaliplatin and nanocurcumin in dendrosomal carrier to inhibits ovarian cancer cells invasion and metastasis through the long non-coding RNA MEG3 [0.03%]
壳聚糖纳米载药体系介导的牛至挥发油对小鼠乳腺癌4T1移植瘤的抑瘤作用研究中文标题：氧化铂和纳米姜黄素在递送树状聚合物中的协同效应通过长链非编码RNA MEG3抑制卵巢癌细胞浸润和转移
Elahe Seyed Hosseini,Marziyeh Alizadeh Zarei,Zahra Shabani et al.
Elahe Seyed Hosseini et al.
Background: Ovarian cancer (OC) remains one of the most lethal gynecological malignancies worldwide. The long non-coding RNA MEG3 (Maternally Expressed Gene 3), located on chromosome 14q32.3, has been identified as a tumo...
Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats [0.03%]
芸竹素对尼古丁致大鼠焦虑抑郁的神经保护作用及单胺能系统、氧化应激和神经炎症的介导机制研究
Murtaza Haidary,Yahya Samadi,Zakaria Rezai et al.
Murtaza Haidary et al.
Introduction: Nicotine withdrawal during adolescence induces severe neurobehavioral disturbances and neurochemical alterations, including anxiety, depression, affective dysregulation, oxidative stress, and neuroinflammati...
Dana F AlKharboush,Frank Kozielski,Geoffrey Wells et al.
Dana F AlKharboush et al.
Three decades after its introduction, fragment-based drug (or lead) discovery (FBDD or FBLD) has become a mature and powerful strategy for generating novel leads, offering distinct advantages for challenging or previously "undruggable" targ...
Salvianolic acid B decreases oxidative stress and alleviates the tumor-promoting effects of arecoline in oral cancer [0.03%]
salvianolic酸B减轻氧化应激并缓解Areca槟榔碱在口腔癌中的促肿瘤作用
Hsuan-Yin Tung,Yi-Ling Ye,Chi-Maw Lin et al.
Hsuan-Yin Tung et al.
Arecoline, which is a primary alkaloid in areca nuts, contributes in key ways to the development of oral submucous fibrosis and the subsequent oral cancer through the induction of oxidative stress, promotion of fibrosis, and activation of o...
Therapeutic effects of vitamin D and omega-3 supplementation on HFHS diet-induced endothelial dysfunction in Wistar rats [0.03%]
维生素D和ω-3脂肪酸补充对高脂高糖饮食诱导的血管内皮功能障碍大鼠的治疗作用研究
Dylan Le Jan,Sandrine Destrumelle,Chantal Thorin et al.
Dylan Le Jan et al.
Background: Obesity impairs cardiovascular health through endothelial dysfunction, which is exacerbated by high-fat high-sugar (HFHS) diets through mechanisms involving chronic inflammation, oxidative stress, and insulin ...
Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update [0.03%]
褪黑素联合抗肿瘤药物或天然产物治疗癌症：最新研究进展
Cristina Trejo-Solís,Irma Susana Rojas-Tomé,Helgi Jung-Cook et al.
Cristina Trejo-Solís et al.
Drug combinations have shown promise in suppressing drug resistance, improving drug efficacy, and reducing side effects in anticancer therapy. Considering that the anticancer activity of melatonin may be due to its antiproliferative, antiox...
MAO-B inhibition by selegiline blunts cardiac functions improved by high-fat diet: Role of inflammation, apoptosis, and calcium-handling [0.03%]
司来吉兰抑制多巴胺β-羟基酶会削弱高脂饮食对心脏功能的改善作用：炎症、凋亡和钙离子稳态的作用
Szabolcs Hambalkó,Csilla Pelyhe,Csenger Kovácsházi et al.
Szabolcs Hambalkó et al.
Background: Obesity is a major risk factor for the development of cardiovascular disease. However, recent research shows that moderate obesity reduces the risk of developing cardiovascular disease. We evidenced before tha...
Targeting telomere dynamics with plant-derived compounds: Molecular strategies against aging [0.03%]
植物衍生化合物靶向端粒动态：对抗衰老的分子策略
Raushanara Akter,Adwiza Chakraborty Bishakha,Raisha Rajib et al.
Raushanara Akter et al.
Telomeres, the repetitive DNA-protein complexes capping eukaryotic chromosomes, preserve genomic stability and regulate cellular replicative capacity. Progressive telomere shortening, coupled with diminished telomerase activity, is a hallma...