Activation of G protein-coupled receptor 40 alleviates STAT6 activation, airway inflammation and mucus hypersecretion in allergic asthma [0.03%]
活化G蛋白偶联受体40缓解过敏性哮喘STAT6激活、气道炎症和黏液高分泌作用
Chantapol Yimnual,Jenjira Sontikun,Vanason Yaovakhan et al.
Chantapol Yimnual et al.
G-protein coupled receptor 40 (GPR40), also termed free fatty acid receptor 1 (FFAR1) is a promising molecular target for treating chronic metabolic and inflammatory diseases. Despite the antiasthmatic benefit of GPR40 agonists such as omeg...
NRPS and PKS pathways in actinomycetes: A review of biosynthetic diversity and bioactive potential [0.03%]
放线菌中NRPS和PKS途径：生物合成多样性和生物活性潜力综述
Abhishek Chauhan,Manisha Gurnani,Jayati Arora et al.
Abhishek Chauhan et al.
Actinomycetes are Gram-positive bacteria renowned for their capacity to produce chemically diverse secondary metabolites with significant pharmaceutical relevance. Widely distributed across marine and terrestrial environments, they exhibit ...
Desloratadine attenuates renal ischemia-reperfusion injury through activation of the Nrf2-GCL-GSH antioxidant pathway [0.03%]
德佐拉特丁通过激活Nrf2-GCL-GSH抗氧化途径减轻肾缺血再灌注损伤
Firouzeh Gholampour,Atefeh Maghsoodi,Khojasteh Malekmohammad
Firouzeh Gholampour
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) in transplantation and major surgery, with limited effective pharmacological interventions. This study evaluated the prophylactic effect of desloratadine,...
Cardiac injury elicited by sub-chronic hookah smoke inhalation, and the alleviating effect of procysteine, 2-oxo-(4R)-4-thiazolidinecarboxylic acid, in BALB/c mice [0.03%]
药用半胱氨酸和2-氧代-(4R)-4硫唑烷甲酸对BALB / c小鼠慢性水烟吸入引起的心脏损伤的治疗作用研究
Sumaya Beegam,Suhail Al-Salam,Bilal M Nemmar et al.
Sumaya Beegam et al.
Hookah smoke (HS) inhalation is known to induce cardiovascular dysfunction, including oxidative stress and inflammation. The procysteine, 2-oxo-(4R)-4-thiazolidinecarboxylic acid (OTC) is a prodrug of cysteine, a precursor of glutathione, w...
Arctiin targets oxidative stress and inflammation, restores Neuregulin-1, and improves neurobehavioral outcomes in neonatal hypoxic-ischemic brain injury [0.03%]
阿特库因通过针对氧化应激和炎症反应、恢复神经营养因子宁拉格林-1治疗新生鼠缺氧缺血性脑损伤提高其神经行为学评分
Skandar Babak,Tahereh Safari,Hamed Fanaei
Skandar Babak
Objective: Hypoxic-ischemic brain damage (HIBD) represents a major cause of neonatal morbidity and mortality, resulting from perinatal oxygen deprivation and impaired cerebral blood flow. This study aims to investigate th...
Corrigendum to "Pharmacogenetics association with long-term clinical evolution in a kidney transplant patients cohort" [Curr. Res. Pharmacol. Drug Discov. 9 (2025) 100230] [0.03%]
“肾脏移植患者队列的药理遗传学与长期临床演变的相关性”一文中错误之处的勘误[刊载于《现化药物研究与发现》2025年第9卷100230页]
Luis Sendra,Gladys G Olivera-Pasquini,Enrique G Zucchet et al.
Luis Sendra et al.
[This corrects the article DOI: 10.1016/j.crphar.2025.100230.]. © 2025 The Author(s).
Anti-Shigella activity and killing kinetics of compounds from MMV Pathogen and COVID Boxes: Identifying leads against Shigellosis [0.03%]
从MMV病原体和COVID药箱中化合物的抗志贺氏菌活性及杀菌动力学研究：寻找治疗志贺菌病的先导化合物
Lauve Rachel Tchokouaha Yamthe,Francine Kengne Mediesse,Yanick Kevin Melogmo Dongmo et al.
Lauve Rachel Tchokouaha Yamthe et al.
Background: Shigellosis is a leading diarrheal disease, posing critical public health challenges in low- and middle-income countries. Rising antibiotic resistance exacerbates treatment limitations. ...
Therapeutic potential, pharmacological role and molecular mechanisms of adelmidrol, an analogue of palmitoylethanolamide [0.03%]
棕榈酸乙醇胺类似物阿德米卓林的治疗潜力、药理作用和分子机制
Bushra Zia,Abdulrahman Alkaabi,Niraj Kumar Jha et al.
Bushra Zia et al.
Adelmidrol is a bioactive semi-synthetic compound with significant therapeutic potential, particularly in resolving inflammation since inflammation plays a key role in the pathogenesis of several diseases. The mechanisms of action of adelmi...
Breaking biofilm barriers in skin wounds: Membrane-Active antimicrobials in an era of resistance [0.03%]
突破皮肤伤口生物膜障碍：耐药时代的膜活性抗菌剂
Lisa Myrseth Hemmingsen,Nataša Škalko-Basnet
Lisa Myrseth Hemmingsen
Chronic wounds remain a significant challenge for healthcare systems worldwide, placing a considerable burden on both patients and resources. Their management is further complicated by the persistence of biofilm-forming bacteria and an esca...
Synergistic effect of oxaliplatin and nanocurcumin in dendrosomal carrier to inhibits ovarian cancer cells invasion and metastasis through the long non-coding RNA MEG3 [0.03%]
壳聚糖纳米载药体系介导的牛至挥发油对小鼠乳腺癌4T1移植瘤的抑瘤作用研究中文标题：氧化铂和纳米姜黄素在递送树状聚合物中的协同效应通过长链非编码RNA MEG3抑制卵巢癌细胞浸润和转移
Elahe Seyed Hosseini,Marziyeh Alizadeh Zarei,Zahra Shabani et al.
Elahe Seyed Hosseini et al.
Background: Ovarian cancer (OC) remains one of the most lethal gynecological malignancies worldwide. The long non-coding RNA MEG3 (Maternally Expressed Gene 3), located on chromosome 14q32.3, has been identified as a tumo...