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4-Hydroxyisoleucine inhibits tumor growth by triggering endoplasmic reticulum stress and autophagy

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4-Hydroxyisoleucine(4-HIL)is a non-protein amino acid that is able to reduce obesity and improve insulin sensitivity in mice, and recently emerged as a drug candidate against hypoglycemia. For the first time, we found that 4-HIL exhibits a potent anti-tumor acti... ...