Cyclodextrin-based therapeutics delivery systems: A review of current clinical trials [0.03%]
基于环糊精的药物递送系统：当前临床试验综述
Gjylije Hoti,Neha Bajwa,Fabrizio Caldera et al.
Gjylije Hoti et al.
This review highlights the current status of cyclodextrin-based formulations tested in human participants, highlighting ongoing clinical research in this area. It provides a comprehensive link between the structure, properties, and clinical...
Unveiling the mechanisms of synthetic compounds against Candida auris: An integrative review [0.03%]
揭秘合成化合物对抗白色念珠菌的机制：综合回顾
Yamini Saini,Zeeshan Fatima,Muriel Billamboz et al.
Yamini Saini et al.
The multidrug-resistant fungal species Candida auris has drawn attention from across the world due to its capacity to elude traditional therapies and flourish in medical environments. Its resilience, which includes biofilm development and e...
The simultaneous activation of μ- and δ-opioid receptors by (-)-2 S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model [0.03%]
(-) -2S-LP2 同时激活μ和δ阿片受体通过转化生长因子β1信号转导救治慢性约束损伤大鼠模型中的异常疼痛
A Fidilio,M Grasso,S Spoto et al.
A Fidilio et al.
In neuropathic pain (NP), a dysregulation of glial functions in the central and peripheral nervous systems has been described, and the balance between pro-inflammatory and anti-inflammatory mediators is lost in the transition from acute to ...
Pharmacogenetics association with long-term clinical evolution in a kidney transplant patients cohort [0.03%]
药理遗传学与肾移植患者的长期临床转归相关性研究
Luis Sendra,Gladys G Olivera-Pasquini,Enrique G Zucchet et al.
Luis Sendra et al.
Background: Pharmacogenetic variability has been reported to influence the efficacy and safety of immunosuppressive therapies in early stages of kidney transplantation. This study investigates long-term associations betwe...
Harnessing Antiviral Peptides: From Molecular Mechanisms to Clinical Translation [0.03%]
抗病毒肽的开发及临床转化：从分子机制到临床应用
Asef Raj,Sabrina Sharmin,Zubaier Ahmed et al.
Asef Raj et al.
Viral infections continue to pose a significant threat to global health, especially with the emergence and re-emergence of resistant viral strains. The limitations of conventional antiviral therapies, such as narrow-spectrum activity, high ...
Advancing organ-on-chip systems: the role of microfluidics in neuro-cardiac research [0.03%]
器官芯片系统的推进：微流控技术在神经-心脏研究中的作用
Maria João Ferreira,Sarah Colombani,Albin Bernardin et al.
Maria João Ferreira et al.
The neuro-cardiac junction is involved in many pathological conditions in humans, but no model currently allows translational studies to investigate its role. Animal models fail to accurately represent this interaction. This review explores...
Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems [0.03%]
基于羟丙基-β-环糊精纳米海绵输送系统的伊布替尼生物利用度优化及评估研究
Sunitha Sampathi,Nitiraj Kulkarni,D V R N Bhikshapathi et al.
Sunitha Sampathi et al.
Background: The current research aims to improve the oral bioavailability of ibrutinib (IBR), a class II drug with low solubility, through the formulation of nanosponges (NSPs) that incorporate IBR, utilizing Hydroxypropy...
Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling [0.03%]
没食子酸可通过调节紧密连接蛋白和细胞因子分泌治疗炎症性肠病
Apiwan Arinno,Pichayapa Sukmak,Purisha Kulworasreth et al.
Apiwan Arinno et al.
Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-β/AMPK/SIRT-1/ERK-depend...
Folic acid supplementation on congenital heart disease and its dual character [0.03%]
叶酸补充与先天性心脏病双重性的关系研究
Yanli Wang,Zhengpei Cheng,Mingfang He et al.
Yanli Wang et al.
Pregnant women are vulnerable to folate deficiency as its requirement is substantially greater than folate requirements for non-pregnant women. Folic acid is a synthetic form of folate and has been used in the fortified foods and nutritiona...
Carnosine modulates Aβ-induced transcriptional aberrations in murine microglial cells [0.03%]
卡尼丁调节Aβ诱导的小鼠小胶质细胞转录异常现象
Veronica Rivi,Giuseppe Carota,Fabio Tascedda et al.
Veronica Rivi et al.
Carnosine (β-alanyl-L-histidine) is an endogenous dipeptide known for its anti-inflammatory and antioxidant effects, making it a promising agent for neurodegenerative diseases like Alzheimer's disease (AD). Carnosine has shown protective e...