microRNAs: An opportunity to overcome significant challenges in malaria detection and control [0.03%]
微小核糖核酸：克服疟疾检测与防治挑战的新机遇
Ruhi Sikka,Praveen Kumar Bharti,Himanshu Gupta
Ruhi Sikka
Organ damage and pathological disease states lead to the rapid release of microRNAs (miRNAs), a class of endogenous small non-coding RNAs, into the blood circulation. Because secreted miRNAs can be detected in biologic fluids such as plasma...
Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders [0.03%]
抑郁症中胃饥饿素介导的神经递质调节作用
Milind V Masule,Sumit Rathod,Yogeeta Agrawal et al.
Milind V Masule et al.
Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growt...
Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine [0.03%]
吉非替尼单用或与氯沙坦及选择性5-羟色胺再摄取抑制剂(Citalopram、Fluoxetine、Fluvoxamine、Paroxetine、Sertraline和Venlafaxine)联用的药代动力学相互作用的临床前研究
Thu-Lan T Luong,Chelsea N Powers,Brian J Reinhardt et al.
Thu-Lan T Luong et al.
Objective: To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs). Methods:...
Choline chloride attenuates the allergic airway disease by inhibiting the lysophosphatidylcholine induced response in mouse model [0.03%]
氯化胆碱通过抑制神经酰胺代谢物诱导的气道炎症反应减轻小鼠过敏性哮喘模型症状研究
Preeti Bansal,Naresh Singh,Jayadev Joshi et al.
Preeti Bansal et al.
Aims: Allergic airway disease manifestation is induced by lysophosphatidylcholine (LPC) through CD1d-restricted Natural killer T (NKT) cells. Choline chloride (ChCl) and LPC both have the "choline" moiety in their structu...
Three-dimensional spheroids of choroid-retinal vascular endothelial cells as an in-vitro model for diabetic retinopathy: Proof-of-concept investigation [0.03%]
用于糖尿病视网膜病变的三维脉络膜-视网膜血管内皮细胞球体模型：概念验证研究
Manish Gore,Ankit Tiwari,Devashree Jahagirdar et al.
Manish Gore et al.
Diabetic retinopathy (DR) is a primary microvascular complication of diabetes mellitus and a vision-threatening condition. Vascular endothelial growth factor (VEGF) induces neovascularization and causes metabolic damage to the retinal and c...
Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis [0.03%]
低剂量蜂毒肽玻璃体内注射安全且可改善实验性葡萄膜炎所致的眼内炎症
Brenda Fernanda Moreira Castro,Carolina Nunes da Silva,Lídia Pereira Barbosa Cordeiro et al.
Brenda Fernanda Moreira Castro et al.
Uveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay of therapy is associated with severe adverse events, prompting the investigation of alternative treatments. The peptide melittin (MEL) is the major compon...
Evaluation of synergism in drug combinations and reference models for future orientations in oncology [0.03%]
评估药物联合治疗的协同作用及未来肿瘤学研究中的参考模型
Diana Duarte,Nuno Vale
Diana Duarte
Current cancer therapy includes a variety of strategies that can comprise only one type of treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for cancer therapy, though sometimes associated with undes...
Neuroprotective effects of combined trimetazidine and progesterone on cerebral reperfusion injury [0.03%]
曲美他嗪联合孕酮对脑再灌注损伤的神经保护效应
Vipin Dhote,Avinash Singh Mandloi,Pradeep Kumar Singour et al.
Vipin Dhote et al.
Cerebral ischemia-reperfusion injury induces multi-dimensional damage to neuronal cells through exacerbation of critical protective mechanisms. Targeting more than one mechanism simultaneously namely, inflammatory responses and metabolic en...
Hydroxycinnamic acid derivatives effect on hypercholesterolemia, comparison with ezetimibe: Permeability assays and FTIR spectroscopy on Caco-2 cell line [0.03%]
羟基桂皮酸类衍生物对高胆固醇血症的影响及其与依折麦布的比较：Caco-2细胞系的通透性测定和FTIR光谱分析
Asma Ressaissi,Maria Luísa M Serralheiro
Asma Ressaissi
High blood cholesterol levels may increase the risk of developing atherosclerosis. Since intestinal cholesterol absorption plays a major role in maintaining total body cholesterol homeostasis, the aim of the present study was to compare the...
New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy [0.03%]
有效癌症治疗的化学药物与siRNA联合疗法新范式
Krishan Kumar,Varsha Rani,Mohini Mishra et al.
Krishan Kumar et al.
Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generate by chemotherapy drugs, including unfavorable harm to healthy cells and multidrug resistance (MDR), persist and have a negative impact on t...