Comparative study of rivastigmine and galantamine on the transgenic Drosophila model of Alzheimer's disease [0.03%]
在阿尔茨海默病转基因果蝇模型中比较石杉碱甲和加兰他敏的研究
Yasir Hasan Siddique,Falaq Naz,Rahul et al.
Yasir Hasan Siddique et al.
Alzheimer's Disease (AD) is characterized as a progressive neurodegenerative disease most commonly associated with memory deficits and cognitive decline. The formation of amyloid plaques and neurofibrillary tangles are important pathologica...
Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents [0.03%]
吲哚：一种有潜力的抗结核药物发现和发展的结构骨架分子
Nilesh Gajanan Bajad,Sudhir Kumar Singh,Sushil Kumar Singh et al.
Nilesh Gajanan Bajad et al.
Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists. Exp...
Promising effects of emoxypine and its succinate derivative in the management of various diseases-with insights on recent patent applications [0.03%]
艾地苯及其苯磺酸衍生物在各种疾病管理中的前景及近期专利申请的见解
Dhruv Sanjay Gupta,Siddhi Bagwe Parab,Ginpreet Kaur
Dhruv Sanjay Gupta
Emoxypine and its succinate derivative share a common hydroxypridine structure, which is similar to pyridoxine. These compounds have been utilized therapeutically and industrially, owing to the wide range of properties offered. This include...
microRNAs: An opportunity to overcome significant challenges in malaria detection and control [0.03%]
微小核糖核酸：克服疟疾检测与防治挑战的新机遇
Ruhi Sikka,Praveen Kumar Bharti,Himanshu Gupta
Ruhi Sikka
Organ damage and pathological disease states lead to the rapid release of microRNAs (miRNAs), a class of endogenous small non-coding RNAs, into the blood circulation. Because secreted miRNAs can be detected in biologic fluids such as plasma...
Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders [0.03%]
抑郁症中胃饥饿素介导的神经递质调节作用
Milind V Masule,Sumit Rathod,Yogeeta Agrawal et al.
Milind V Masule et al.
Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growt...
Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine [0.03%]
吉非替尼单用或与氯沙坦及选择性5-羟色胺再摄取抑制剂(Citalopram、Fluoxetine、Fluvoxamine、Paroxetine、Sertraline和Venlafaxine)联用的药代动力学相互作用的临床前研究
Thu-Lan T Luong,Chelsea N Powers,Brian J Reinhardt et al.
Thu-Lan T Luong et al.
Objective: To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs). Methods:...
Choline chloride attenuates the allergic airway disease by inhibiting the lysophosphatidylcholine induced response in mouse model [0.03%]
氯化胆碱通过抑制神经酰胺代谢物诱导的气道炎症反应减轻小鼠过敏性哮喘模型症状研究
Preeti Bansal,Naresh Singh,Jayadev Joshi et al.
Preeti Bansal et al.
Aims: Allergic airway disease manifestation is induced by lysophosphatidylcholine (LPC) through CD1d-restricted Natural killer T (NKT) cells. Choline chloride (ChCl) and LPC both have the "choline" moiety in their structu...
Three-dimensional spheroids of choroid-retinal vascular endothelial cells as an in-vitro model for diabetic retinopathy: Proof-of-concept investigation [0.03%]
用于糖尿病视网膜病变的三维脉络膜-视网膜血管内皮细胞球体模型：概念验证研究
Manish Gore,Ankit Tiwari,Devashree Jahagirdar et al.
Manish Gore et al.
Diabetic retinopathy (DR) is a primary microvascular complication of diabetes mellitus and a vision-threatening condition. Vascular endothelial growth factor (VEGF) induces neovascularization and causes metabolic damage to the retinal and c...
Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis [0.03%]
低剂量蜂毒肽玻璃体内注射安全且可改善实验性葡萄膜炎所致的眼内炎症
Brenda Fernanda Moreira Castro,Carolina Nunes da Silva,Lídia Pereira Barbosa Cordeiro et al.
Brenda Fernanda Moreira Castro et al.
Uveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay of therapy is associated with severe adverse events, prompting the investigation of alternative treatments. The peptide melittin (MEL) is the major compon...
Evaluation of synergism in drug combinations and reference models for future orientations in oncology [0.03%]
评估药物联合治疗的协同作用及未来肿瘤学研究中的参考模型
Diana Duarte,Nuno Vale
Diana Duarte
Current cancer therapy includes a variety of strategies that can comprise only one type of treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for cancer therapy, though sometimes associated with undes...