Precision theranostics in cervical Cancer: Harnessing stimuli-responsive hydrogels for tumor microenvironment-targeted therapy and diagnosis [0.03%]
针对肿瘤微环境的刺激响应型水凝胶在宫颈癌精确诊断与治疗中的应用研究
Yu Zhang,Yueda Lu,Sidi Li et al.
Yu Zhang et al.
Cervical cancer continues to pose a significant threat to women's health worldwide, with conventional therapies often limited by drug resistance and systemic toxicity. Stimuli-responsive hydrogels have recently emerged as promising platform...
NIR-absorbing organic charge transfer complexes for photothermal antibacterial therapy and wounds healing [0.03%]
用于光热抗菌治疗和伤口愈合的近红外吸收型有机电荷转移复合材料
Peirong Bai,Qiong Zhang,Xiaoyu Zhang et al.
Peirong Bai et al.
Bacterial infections and subsequent inflammation are major obstacles to efficient wound healing and present an increasing clinical challenge due to rising antimicrobial resistance. Photothermal therapy (PTT) offers a non-antibiotic, spatiot...
Structure-centered design of lipid-based nanocarriers to overcome biological barriers [0.03%]
基于结构的脂质纳米载体设计以克服生物屏障
Yeeun Woo,Jinwook Yoon,Yoseph Seo et al.
Yeeun Woo et al.
As technology has evolved in response to pressing human challenges, drug delivery systems (DDSs) have also evolved to overcome complex biological barriers. Particularly, the continuous development of therapeutic strategies has enabled the i...
Magnetically guided neurite outgrowth modulated by PIEZO1 in hiPSC-derived retinal ganglion cells [0.03%]
hiPSC来源视网膜神经节细胞中PIEZO1调节的磁性导向树突状突起生长
I-Ting Chen,Pei-Hsin Chu,Shang-Hsiu Hu et al.
I-Ting Chen et al.
Retinal ganglion cell (RGC) axon degeneration is one of the major causes of vision loss in glaucoma, where regeneration remains limited by the central nervous system's low intrinsic repair capacity. We applied a magnetic-guided nanotechnolo...
Serum and urine metabolic fingerprints enable diagnosis and prognosis for IgA nephropathy [0.03%]
血清和尿液代谢指纹能够用于iga肾病的诊断和预后判断
Beili Wang,Ruimin Wang,Wenqi Shao et al.
Beili Wang et al.
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, displays a pronounced geographical variation and progresses to end-stage renal disease within 20 years in 20-40 % of patients. However, current clinical managemen...
TLyp-1-modified exosome-mediated delivery of circRAPGEF5 ASO inhibits lung adenocarcinoma metastasis via regulating the miR-570-3p/SPP1 axis [0.03%]
TLyp-1修饰的外泌体递送circRAPGEF5 ASO通过调控miR-570-3p/SPP1轴抑制肺腺癌转移
Tianqi Hu,Chenkang Zhou,Yuxin Chen et al.
Tianqi Hu et al.
Exosome circRAPGEF5 promotes lung adenocarcinoma (LUAD) metastasis and may serve as an intervention target, but its mechanism of action is unclear. Consequently, using engineered exosomal preparations of circular RNAs for delivery into tumo...
Tooth-on-a-chip to engineer early dental epithelial-mesenchymal interaction [0.03%]
牙齿芯片：工程早期牙上皮间充质相互作用
C Huang,F Sanaei,W Zhang et al.
C Huang et al.
Tooth enamel-the highly mineralized outer layer shielding teeth from mechanical and chemical wear-is produced during development by specialized dental epithelial (DE) cells called ameloblasts. Functional enamel is challenging to regenerate ...
Recent advances in nanoparticles-based sonodynamic and immune checkpoint blockade synergistic therapy for pancreatic ductal adenocarcinoma [0.03%]
基于纳米颗粒的声动力和免疫检查点阻断协同治疗胰腺导管腺癌的最新进展
Haijie Li,Ying Lei,Yunqing Tian et al.
Haijie Li et al.
Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its dense fibrotic stroma, hypovascular characteristics, and immunosuppressive tumor microenvironment (TME), which collectively hinder effective drug deliv...
Yao Zhang,Haiyang Li,Guangwei Li et al.
Yao Zhang et al.
The painless, non-invasive and highly efficient microneedle drug delivery method has received extensive attention from the medical community in recent years. Among all the microneedle technologies, the hydrogel-forming microneedle (HFM) tec...
Lipoic acid zwitterionic polymer engineered nanozymes ferried by neutrophil reprogramming ischemic microenvironment for stroke treatment [0.03%]
用于卒中治疗的通过中性粒细胞重编缺血微环境输送的泛酸离子型聚合物工程化纳米酶
Mengcheng Guo,Haoyu Li,Qingran Guan et al.
Mengcheng Guo et al.
The accumulation of pathological reactive oxygen species (ROS) after reperfusion of ischemic stroke (IS) triggers the cascade of "oxidative stress-mitochondrial apoptosis-NLRP3 pyroptosis", which aggravates neuronal death and neuroinflammat...