Recombinant collagen in regenerative medicine: Expression strategies, structural design, and translational applications [0.03%]
再生医学中的重组胶原蛋白：表达策略、结构设计和转化应用
Huixia He,Mingzhu Ye,Guoqi Cui et al.
Huixia He et al.
Recombinant collagen represents a new generation of biomaterials that integrate molecular precision, functional tunability, and scalable biomanufacturing. While animal-derived collagens remain clinically established, their inherent biologic...
Axolotl-derived decellularized skin ECM as a pro-regenerative scaffold for attenuating fibrotic wound healing [0.03%]
轴靴提取的脱细胞皮肤ECM作为促再生支架以减轻瘢痕修复
Mu-Hui Wang,Chen-Hsiang Kuan,Hsu Ma et al.
Mu-Hui Wang et al.
Conventional wound healing in mammals often results in fibrosis, leading to permanent scarring and compromised skin function. Inspired by the remarkable regenerative capacity of axolotls, we developed an axolotl skin decellularized extracel...
A matrix metalloproteinase-responsive hydrogel with spatially orchestrated delivery of stem cells and raleukin for enhanced bone regeneration [0.03%]
一种基质金属蛋白酶响应性水凝胶通过空间有序递送干细胞和募集中枢记忆T细胞促进骨再生
Kai Xie,Zhengwei Liu,Kai Chen et al.
Kai Xie et al.
Stem cell therapy has demonstrated efficacy in treating bone defects. However, a critical challenge remains in effectively anchoring stem cells at the defect site and creating a conducive microenvironment that supports their proliferation a...
Recent advances in hydrogel-based delivery systems for the treatment of pancreatic cancer [0.03%]
用于治疗胰腺癌的水凝胶基递送系统最新进展
Haibo Wang,Hongyuan Yu,Xue Bai et al.
Haibo Wang et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate below 10 %, largely due to late diagnosis, aggressive progression, and intrinsic resistance to conventional therapies. The d...
Sustained drug-releasing hydrogel coatings for ureteral stents to prevent iatrogenic injury-induced ureteral stricture [0.03%]
长效药物释放水凝胶输尿管支架涂层以预防医源性损伤引起的输尿管狭窄
Dawei Tian,Jian Wang,Guoqiang Han et al.
Dawei Tian et al.
Iatrogenic injury-induced ureteral stricture often occurs during the treatment of ureteral disorders, and can lead to serious consequences requiring further medical care. The stricture prevention requires effective strategies to inhibit fib...
Preparation and evaluation of an injectable HAp/Col I composite for promoting tendon-to-bone healing in ACL reconstruction [0.03%]
一种促进前交叉韧带重建中肌腱骨愈合的注射型HAp/Col I复合材料的研究与评价
Zhanhong Liu,Qingsong Jiang,Liren Wang et al.
Zhanhong Liu et al.
Tendon-to-bone healing is considered as a critical determinant influencing the quality of anterior cruciate ligament (ACL) reconstruction. The establishment of a microenvironment conducive to tendon-bone healing remains an urgent challenge ...
Microbiota-directed lactic acid depleting nanoenzyme reactivates antitumor immunity and chemosensitivity in hypoxic tumor [0.03%]
微生物群靶向乳酸耗竭型纳米酶可在缺氧肿瘤中重振抗肿瘤免疫和化疗敏感性
Xinyue Lan,Fengling Zhang,Guangman Cui et al.
Xinyue Lan et al.
The acidification of the tumor microenvironment (TME) remains a major obstacle contributing to malignant progression and impeding therapeutic development. While traditionally attributed to anaerobic glycolysis, increasing evidence suggests ...
Icariin-loaded GelMa hydrogel encapsulated potassium sodium niobate biomimetic piezoelectric scaffold regulates macrophage polarization to accelerate bone defect repair [0.03%]
载有淫羊藿黄酮的明胶美满哈氏骨支架调节巨噬细胞极化以促进骨缺损修复
Yongbin Wang,Han Zhang,Zhili Xu et al.
Yongbin Wang et al.
Large bone defects present significant clinical challenges due to limitations of current treatments including immune rejection, infection, and poor osteoinductive capacity. This study developed a novel biomimetic piezoelectric scaffold syst...
Multifunctional hydrogel sensors with dynamic covalent networks for machine learning-assisted Parkinson's disease diagnosis and encrypted human-computer interaction [0.03%]
用于机器学习辅助帕金森病诊断和加密人机交互的多功能动态共价网络水凝胶传感器
Siqi Ding,Xiao Yu,Qi Wang et al.
Siqi Ding et al.
Flexible sensors hold significant application value in the fields of human-computer interaction and medical monitoring. In this study, we developed a smart hydrogel strain sensor based on dynamic covalent cross-linking. A multifunctional hy...
Photothermal-triggered non-apoptotic regulated cell death-related pathway regulation boosts systemic antitumor immunity [0.03%]
光热触发的非凋亡调控细胞死亡通路调节增强全身抗肿瘤免疫反应
Yanting Liang,Haitao Yuan,Qiu Jin et al.
Yanting Liang et al.
Overcoming tumor cell resistance to apoptosis and immunosuppression remains a formidable challenge in tumor immunotherapy. There is a critical need to explore alternative cell death pathways to remodel the immunosuppressive tumor microenvir...