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Transient blood-brain barrier opening by focused ultrasound enhances ferumoxytol accumulation in glioblastoma

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Nanoparticle delivery to glioblastoma is limited by the blood-brain barrier (BBB), which restricts the transport of diagnostic and therapeutic agents into tumor tissue. Microbubble-mediated focused ultrasound (FUS) can transiently increase BBB permeability and... ...