Cell-specific epigenome-wide DNA methylation in peripheral CD4(+) lymphocytes from patients with primary biliary cholangitis [0.03%]
原发性胆汁性胆管炎患者外周CD4(+)淋巴细胞的细胞特异性DNA甲基化组图谱分析
Pinelopi Arvaniti,Kalliopi Zachou,Aggeliki Lyberopoulou et al.
Pinelopi Arvaniti et al.
Background/aims: Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease, triggered by a complex interplay between genetic, environmental and epigenetic factors. We investigated the methylation...
"CANDLE syndrome: A closer look at a rare autoinflammatory disorder" [0.03%]
烛焰征综合症：一种罕见的自身炎症性疾病的深入研究
Shivam Singh,Ashish Kumar Sharma
Shivam Singh
A newly identified autoinflammatory condition called CANDLE syndrome (chronic atypical neutrophilic dermatosis with lipodystrophy and increased temperature) is characterized by early onset, recurring fever, skin lesions, and multisystemic i...
Wenjie Zhu,Fan Li,Yuchen Zhang et al.
Wenjie Zhu et al.
Rheumatic heart disease (RHD), an autoimmune injury triggered by group A streptococcus (GAS) infection, exerts a significant pathological impact on the human heart. The pathogenesis of RHD is closely associated with abnormal epigenetic regu...
Data-driven classification of primary Sjögren's syndrome: From cluster analysis to clinical immune phenotypes and predictive biomarkers [0.03%]
基于数据的一类原发性舍格伦综合征的分类：从聚类分析到临床免疫表型和预测生物标志物
Jianbin Li,Suiran Li,Wei Liu
Jianbin Li
Background: Primary Sjögren's Syndrome (pSS) exhibits significant clinical heterogeneity, and traditional organ-based classification systems fail to capture the underlying disease mechanisms. This study aims to identify ...
Rheumatoid factor and anti-citrullinated protein IgA antibodies in the diagnosis, prognosis and monitoring of patients with rheumatoid arthritis [0.03%]
风湿因子和抗瓜氨酸蛋白IgA抗体在类风湿关节炎诊断、预后及监测中的作用
Ulrike Steffen,Daniela Sieghart,Günter Steiner
Ulrike Steffen
Over the past decades immunoglobulin A (IgA) antibodies have gained increasing attention for their diagnostic and prognostic significance in rheumatoid arthritis (RA), complementing the well-established roles of IgM rheumatoid factor (RF) a...
Epidemiological assessment of six major immune-mediated inflammatory diseases based on the Global Burden of Disease Study 2021: analyses of age-standardized incidence, prevalence, mortality, and disability-adjusted life years [0.03%]
基于全球疾病负担研究（2021）的六种主要免疫介导性炎症性疾病流行病学评估：年龄标化发病率、患病率、死亡和伤残调整生命年的分析
Mengyu Huang,Zhaoli Ma,Xiu Luo et al.
Mengyu Huang et al.
Objective: Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and tissue inflammation, posing a significant challenge to global health. However, ...
Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data [0.03%]
基于蛋白质组学和基因组学数据的自身免疫疾病与贫血因果关系的孟德尔随机化研究
Xin Zhuang,Tianen Pan
Xin Zhuang
Background: Observational studies have suggested a potential association between autoimmune diseases and anemia, but the direction of causality remains unclear. To investigate the potential causal relationship between aut...
Nasser Gholijani,Effat Noori,Zeinab Zarei-Behjani et al.
Nasser Gholijani et al.
Vitiligo is a chronic, acquired skin disorder characterized by the loss of pigmentation due to the destruction or dysfunction of melanocytes. Conventional treatments such as corticosteroids and phototherapy often produce limited and unpredi...
Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders [0.03%]
一种选择性靶向PDE4B和PDE4D双功能降解剂的发现用于慢性炎症紊乱的治疗
Arvind Shakya,Qiao Liu,Chon Lai et al.
Arvind Shakya et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by redness and itching, impacting over 15 million individuals in the US. The pathogenesis of AD involves T helper 2 (TH2) and 17 (TH17) cytokines, which contribute...
Divergent trajectories of inflammatory bowel disease in East, South, South-East and Central Asia: A comprehensive GBD 2021 analysis [0.03%]
基于GBD 2021的分析：亚洲各地炎症性肠病的发展轨迹差异较大
Kui Wang,Yunqing Zeng,Shanshan Zhang et al.
Kui Wang et al.
Background: Inflammatory bowel disease (IBD) is no longer confined to Western populations; its burden is rising across Asia, a region with marked demographic, economic, and health-system heterogeneity. Quantifying contemp...