Regulatory T cell therapy for Sjögren's disease: From pathogenesis to targeted treatment [0.03%]
自身免疫性疾病的Tregs细胞治疗：从发病机制到靶向治疗研究
Zhi Feng Sherman Lim,Alberta Y Hoi,Fabien B Vincent et al.
Zhi Feng Sherman Lim et al.
Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by lymphocytic infiltration of the salivary and lacrimal glands, leading to the hallmark symptoms of dry eyes and dry mouth. Beyond glandular dysfunction, many...
Beyond conventional treatment: Novel cell therapies for systemic lupus erythematosus [0.03%]
超越传统治疗：系统性红斑狼疮的新型细胞疗法
Zeinab Zarei-Behjani,Arghavan Hosseinpouri,Maryam Fotoohi et al.
Zeinab Zarei-Behjani et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by its heterogeneity, as it can affect various organs and exhibit a diverse clinical progression. The identification of SLE relies on the presence of distinct clinica...
When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP [0.03%]
当“受害者”变成“加害者”：ITP中血小板作为免疫调节紊乱驱动者的角色
Fatemeh Farhid,Hadi Rezaeeyan,Reza Habibi et al.
Fatemeh Farhid et al.
Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by immune-mediated destruction of platelets and impaired platelet production. Although autoantibodies have historically been central to the understanding of ...
Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation [0.03%]
靶向定位的聚乙二醇修饰的白细胞介素-2激活调节性T细胞可减轻自身免疫炎症
Masahiro Ikeda,Shinpei Yamaguchi,Shigeki Takaoka et al.
Masahiro Ikeda et al.
Dysregulation of immune homeostasis accompanied by regulatory T cell (Treg) dysfunction is a hallmark of various autoimmune and inflammatory diseases. While low-dose interleukin-2 (IL-2) treatment can enhance Treg levels and alleviate disea...
Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint [0.03%]
肉碱酰基化物丰度是类风湿关节滑膜成纤维样细胞代谢特征的标志
Georgios K Vasileiadis,Yuan Zhang,Marion Laudette et al.
Georgios K Vasileiadis et al.
Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performi...
Ye Zeng,Erika Boschmann,Julia Kotte et al.
Ye Zeng et al.
ANCA-vasculitis (AAV) is a small-vessel vasculitis characterized by the presence of autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO). The dynamics of the T-cell response within tissues is studied best in animal models. It ...
MiR-122-5p modulates ferroptosis via SLC7A11: A potential therapeutic target in autoimmune hepatitis [0.03%]
miR-122-5p通过SLC7A11调节铁死亡：自身免疫性肝炎的潜在治疗靶点
Yuhong Suo,Yu Wang,Yu Su et al.
Yuhong Suo et al.
Background & aims: Autoimmune hepatitis (AIH) is a relatively rare cause of liver disease with a poor prognosis without intervention. Ferroptosis, a classical form of cell death, plays a crucial role in various diseases, ...
Exploration of shared biomarkers and mechanisms in systemic lupus erythematous and lung cancer via bioinformatics analysis [0.03%]
基于生物信息学分析探索系统性红斑狼疮和肺癌共有的生物标志物及机制
Chueh-Hsuan Hsu,Shuo-Chueh Chen,Yung-Luen Yu
Chueh-Hsuan Hsu
Systemic lupus erythematosus (SLE) patients exhibit a heightened risk of developing lung cancer, yet the underlying molecular mechanisms remain poorly understood. This study aimed to identify shared genetic factors linking SLE and LC using ...
A laboratory test to detect gliadin-specific CD4+ T-cells for difficult to diagnose celiac disease [0.03%]
用于诊断难以发现的乳糜泻的gliadin特异性CD4+T细胞实验室检测法
Daan A R Castelijn,Nicolette J Wierdsma,Kim de Buck et al.
Daan A R Castelijn et al.
Objectives: Discrepancy between serology and small bowel histology, such as seronegative CD, poses a diagnostic challenge in celiac disease (CD) diagnosis. Recently described methods to detect gliadin-specific T-cells are...
Hyperimmunoglobulin syndromes: A review of HIGM, HIES, and HIDS [0.03%]
高免疫球蛋白综合征：HIGM、HIES 和 HIDS 综述
Wushu Chen,Xingpei Li,Junye Mai et al.
Wushu Chen et al.
At present, there is a lack of detailed understanding and research on the pathogenesis and treatment of Hyperimmunoglobulin M syndrome (HIGM), Hyperimmunoglobulin E syndrome (HIES), and hyperimmunoglobulin D syndrome (HIDS), and few studies...