Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders
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Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by redness and itching, impacting over 15 million individuals in the US. The pathogenesis of AD involves T helper 2 (TH2) and 17 (TH17) cytokines, which contribute to increased inflam... ...
