Jackson Kyle Sundgren,Taylor Elijah Martin,Suvitha Viswanathan et al.
Jackson Kyle Sundgren et al.
The Ras homolog gene family member A (RhoA) is a small GTPase. RhoA plays major roles in cytoskeletal regulation, transcriptional control, and cell cycle maintenance. RhoA is widely expressed in the female reproductive system (FRS). In vitr...
Causal relationships between leukocyte telomere length and female reproductive system diseases: a bidirectional Mendelian randomization study [0.03%]
白细胞端粒长度与女性生殖系统疾病之间的因果关系：双向孟德尔随机化研究
Jun-Sen She,Rui Liu,Su-Qing Mao et al.
Jun-Sen She et al.
Objective: Although numerous observational studies have revealed a correlation between leukocyte telomere length (LTL) and female reproductive system diseases (RSDs), the findings of these studies have tended to be consis...
Mendelian randomization evidence for lung function mediates the association between childhood allergies (age [0.03%]
孟德尔随机化证据支持肺功能介导儿童过敏与成人哮喘之间的关联年龄
Yu-Hang Long,Jun-Sen She,Fei Guo et al.
Yu-Hang Long et al.
Objective: This study aimed to investigate the influence of lung function on the relationship between allergies and hypertension, thereby elucidating significant potential mechanisms from a genetic standpoint. We investig...
Atp6v0d2 deficiency partially restores defects in Mcoln1-deficient mouse corpus luteum [0.03%]
Atp6v0d2缺乏部分恢复Mcoln1缺乏的小鼠黄体的缺陷
Yuehuan Li,Ahmed E El Zowalaty,Jonathan Matthew Hancock et al.
Yuehuan Li et al.
Objective: ATP6V0d2 is a subunit of the vacuolar-type H+-ATPase (V-ATPase) that pumps H+ ions into lysosomes. TRPML1 (MCOLN1/Mcoln1) transports cations out of lysosomes. Mcoln1 -/- mice recapitulate the lysosomal storage ...
Yuehuan Li,Zidao Wang,Christian L Andersen et al.
Yuehuan Li et al.
The lysosome is the most acidic membrane-bound intracellular organelle. Lysosomal acidity is primarily maintained by vacuolar H+-ATPase (V-ATPase) and counter ion channels. There are >60 hydrolytic enzymes in the lysosome for its fundamenta...
Exogenous estrogen partially rescues progesterone deficiency and autophagosome enlargement in Mcoln1 -/- mouse model with lysosomal storage disorder [0.03%]
外源性雌激素可部分挽救Mcoln1基因敲除小鼠模型中孕酮缺乏和自噬溶酶体肿大现象
Zidao Wang,Yuehuan Li,Christian L Andersen et al.
Zidao Wang et al.
Objective: Female Mcoln1 -/- mice exhibit progressive progesterone (P4) deficiency, luteal cell degeneration, and premature embryo implantation failure at 5 months old. We attempted to rescue embryo implantation in non-vi...
Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment [0.03%]
临近胚胎附植时减弱的视黄酸信号是小鼠子宫的早期反应之一
Honglu Diao,Shuo Xiao,Tong Zhou et al.
Honglu Diao et al.
The uterus is transiently receptive for embryo implantation. It remains to be understood why the uterus does not reject a semi-allogeneic embryo (to the biological mother) or an allogeneic embryo (to a surrogate) for implantation. To gain i...
Chen-Yang Huang,Hai-Xiang Sun,Jie Mei
Chen-Yang Huang
The impact of coronavirus disease 2019 (COVID-19) on endometriosis (EM) is currently unclear. Here, we aimed to describe the potential influence of COVID-19 on the pathogenesis, clinical symptoms, and treatment of EM. The cytokine storm cau...
Peripheral blood transcriptome analysis of patients with ovarian hyperstimulation syndrome through high-throughput sequencing [0.03%]
通过高通量测序技术分析多囊卵巢综合征患者外周血转录组
Bo Yan,Bin Wu,Zhi-Qiang Wang et al.
Bo Yan et al.
Ovarian hyperstimulation syndrome (OHSS) is a frequent iatrogenic complication that arises during assisted reproduction and accounts for approximately 30% of all in vitro fertilization cycles. Using high-throughput sequencing, we investigat...
Characterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development [0.03%]
叶酸、5-甲基四氢叶酸和亚硫酸氢盐稳定的合成型叶酸在高亲和力叶酸转运蛋白中的特征化：对妊娠及发育的影响
Ana M Palacios,Rachel A Feiner,Robert M Cabrera
Ana M Palacios
Folates are B vitamins that are essential for several molecular, cellular, and biological processes, including nucleotide synthesis, methylation, and methionine cycling. The physiological impacts of these processes on health also extend to ...