Single-cell Analysis Reveals a LAMB3-dependent Immunosuppressive Environment in Gallbladder Neck/Cystic Duct Carcinoma [0.03%]
Xuebing Shi,Shuai Li,Mixue Bai et al.
Xuebing Shi et al.
Background & aims: Gallbladder cancer (GBC) originating from the fundus/body (GBCF/B) and neck/cystic duct (GBCN/CD) exhibits distinct clinical outcomes. Location-associated heterogeneity is intricately linked to oncogeni...
Targeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma [0.03%]
Tommaso Mello,Irene Simeone,Alice Guida et al.
Tommaso Mello et al.
Background & aims: The AAA+ ATPase RuvBL1 takes part in several biological processes, including chromatin remodelling and DNA repair, ribosome biogenesis, mTOR signalling, and oncogenic transformation. RUVBL1 overexpressi...
Scientific, regulatory, and practical considerations for bringing hepatocellular carcinoma biomarkers into clinical practice [0.03%]
Blanca Botía Martínez-Artero,Eleonora Alimenti,James K Carter et al.
Blanca Botía Martínez-Artero et al.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide; early detection and accurate prediction of treatment response remain major clinical challenges. Current screening methods suffer from limited s...
AI-guided automated identification of patients at high-risk for hepatocellular carcinoma in large US and Global datasets [0.03%]
Eric Lahtinen,Kai Jia,Bowen Gu et al.
Eric Lahtinen et al.
Background & aims: Hepatocellular Carcinoma (HCC) screening targets patients with cirrhosis but lacks risk stratifi- cation and misses non-cirrhotic cases. We evaluated whether LIver cancer RIsk Computation (LIRIC) models...
Wilson disease is a single gene disorder - comprehensive analysis of patients with prior negative genetic testing [0.03%]
Dorte L Lildballe,Anne Grosen,Peter Ott et al.
Dorte L Lildballe et al.
Background & aims: Wilson disease (WD) is an autosomal recessive disorder caused by damaging ATP7B variants. Up to 20% of clinically diagnosed cases remain genetically unexplained. We aimed to analyze patients with WD (Le...
Loss of Hepatocyte PI3Kα Reduces Hepatocellular Carcinoma and Hepatocyte Proliferation in Association with Altered Lipid Metabolism [0.03%]
Barbara Becattini,Claudia Sardi,Bart Edelbroek et al.
Barbara Becattini et al.
Background and aims: Hepatocellular carcinoma (HCC) is a disease with an increasing incidence and a high mortality rate. Thus, targeted therapies for HCC are urgently needed. PI3K-AKT-mTORC1 signaling is frequently induce...
Efficacy and safety of immune checkpoint inhibitors in patients with high microsatellite instability/mismatch repair-deficient advanced cholangiocarcinoma: A propensity score-matched study [0.03%]
Mingjian Piao,Xu Yang,Chengjie Li et al.
Mingjian Piao et al.
Background & aims: Microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) cholangiocarcinoma (CCA) represents a rare molecular subtype with potential sensitivity to immune checkpoint inhibitors (ICIs). How...
Spatial profiling defines three immunophenotypes and a perineural invasion-associated immune-evasion niche in gallbladder cancer [0.03%]
Xing He,Xin Yang,Sicheng Xu et al.
Xing He et al.
Background & aims: Gallbladder cancer (GBC) has a high risk of postoperative recurrence, and immunotherapy-based adjuvant approaches remain unstandardised. We aimed to define spatial immunophenotypes in GBC and evaluate t...
Henriette Kreimeyer,Marcos F Fondevila,Aenne Harberts et al.
Henriette Kreimeyer et al.
Background & aims: Transitioning from yeast to hyphal morphology enables Candida albicans (C. albicans) to secrete candidalysin, invade the intestinal mucosa and translocate to the blood stream. Patients with alcohol-asso...
Raza Ur Rahman,Eliana T Epstein,Shane Murphy et al.
Raza Ur Rahman et al.
Background & aims: The liver is a vital organ composed of parenchymal, non-parenchymal, and immune cell populations. Single-cell sequencing approaches now provide the opportunity to understand how sex and age influence ge...