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Loss of Hepatocyte PI3Kα Reduces Hepatocellular Carcinoma and Hepatocyte Proliferation in Association with Altered Lipid Metabolism

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Background and aims: Hepatocellular carcinoma (HCC) is a disease with an increasing incidence and a high mortality rate. Thus, targeted therapies for HCC are urgently needed. PI3K-AKT-mTORC1 signaling is frequently induced in sol... ...