Viral sequence analysis of chronic hepatitis B patients treated with the siRNA JNJ-73763989 in phase II clinical trials [0.03%]
siRNA(JNJ-73763989)治疗慢性乙型肝炎患者Ⅱ期临床试验的病毒学序贯分析
Thierry Verbinnen,Erkki Lathouwers,John Jezorwski et al.
Thierry Verbinnen et al.
Background & aims: JNJ-73763989 (JNJ-3989) is a small-interfering RNA composed of two triggers targeting the HBsAg and HBx protein open reading frame, designed to target all HBV RNAs for degradation. JNJ-3989 + nucleos(t)...
Comparative effectiveness of antidiabetic therapies on hepatic decompensation in patients with type 2 diabetes: A target trial emulation [0.03%]
模拟目标试验评估2型糖尿病患者降糖治疗对肝失代偿效应的优劣
Jonggi Choi,Ana Verma,Vy H Nguyen et al.
Jonggi Choi et al.
Background & aims: The comparative effectiveness of antidiabetic therapies on hepatic outcomes in patients with type 2 diabetes mellitus (T2DM) is not well established. ...
Pre-emptive TIPS should be considered in high-risk patients with both acute variceal bleeding and severe alcohol-related hepatitis [0.03%]
对于同时患有急性静脉曲张出血和严重酒精性肝炎的高危患者应考虑预防性TIPS手术
Marika Rudler,Virginia Hernandez Gea,Hélène Larrue et al.
Marika Rudler et al.
Background & aims: Severe alcohol-related hepatitis (AH) and acute variceal bleeding (AVB) may occur simultaneously. The impact of a pre-emptive transjugular intrahepatic portosystemic shunt (pTIPS) in high-risk patients ...
Janine Dywicki,Laura Elisa Buitrago-Molina,Anna K Baumann et al.
Janine Dywicki et al.
Background & aims: Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) affects around 30% of the world's population and is often associated with metabolic conditions such as obesity, diabetes and hypertension...
Macrophage MRC2 deficiency mitigates HFD-induced MASLD by downregulating CD147-regulated TNF-α production [0.03%]
巨噬细胞MRC2缺乏通过下调CD147调节的TNF-α产生缓解HFD诱导的MASLD
Hui-Ru Kuo,Kwei-Yan Liu,Hsin-Ying Clair Chiou et al.
Hui-Ru Kuo et al.
Background & aims: The mechanisms underlying metabolic dysfunction-associated steatotic liver disease (MASLD) remain incompletely understood, and macrophage-associated chronic inflammation has been suggested to play a rol...
The efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes [0.03%]
阿特珠单抗联合贝伐单抗治疗晚期肝细胞癌的疗效与肿瘤浸润淋巴细胞的关系
Hiroaki Kanzaki,Takamasa Ishino,Sadahisa Ogasawara et al.
Hiroaki Kanzaki et al.
Background & aims: Atezolizumab plus bevacizumab (Atez/Bev) improves prognosis in advanced hepatocellular carcinoma, but its mechanisms remain unclear. This study aims to identify predictive biomarkers through a comprehen...
Diagnostic accuracy of transient elastography in MASLD is independent of MRI-PDFF steatosis in a multicenter study [0.03%]
多中心研究发现：肝瞬时弹性图诊断代谢相关脂肪性肝病的准确性与MRI-PDFF脂肪变无关
Oumnia Masrour,Florent Ehrhard,Maeva Guillaume et al.
Oumnia Masrour et al.
Background: Transient elastography (TE) can be used to accurately screen for severe liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). However, some studies suggest that steatosis influenc...
Transcriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse [0.03%]
来自肝脏、大脑和骨髓的单核细胞转录组揭示了衰老和酒精滥用中的器官特异性特征
Martí Ortega-Ribera,Radhika Joshi,Sergi Guixé-Muntet et al.
Martí Ortega-Ribera et al.
Background & aims: Aging and alcohol misuse independently alter monocyte (MO) and macrophage (MØ) function, leading to impaired antimicrobial responses. However, how alcohol misuse contributes to impaired MO/MØ function...
Tumor peripheral stiffness modulates lenvatinib resistance in HCC preclinical models by regulating FIS1-dependent mitophagy [0.03%]
肿瘤周边刚度通过调节FIS1依赖性线粒体自噬来调控肝癌预临床模型中的仑伐替尼耐药性
Kunjin Wu,Jing Li,Yunong Fu et al.
Kunjin Wu et al.
Background & aims: Hepatocellular carcinoma (HCC) displays heterogeneous responses to lenvatinib, with tumor microenvironment (TME) stiffness emerging as a key resistance modulator. This study investigates how tumor perip...
Failure-to-rescue as a determinant of overall survival following resection for perihilar cholangiocarcinoma [0.03%]
术后救治失败作为肝门胆管癌切除术患者总生存率的决定因素
Yawen Dong,Zhihao Li,Vanja Podrascanin et al.
Yawen Dong et al.
Background & aims: Perihilar cholangiocarcinoma (pCCA) is a surgically challenging malignancy associated with a high risk of postoperative complications. However, advances in surgical techniques, perioperative care, and s...