A subset of hepatic fibroblasts marked by Gli1 expression generates portal fibrosis and promotes ductular reaction [0.03%]
Mariana Amaral Raposo,Haquima El Mourabit,Wenrui Gao et al.
Mariana Amaral Raposo et al.
Background & aims: Gli1+ cells were previously described as myofibroblast precursors. We aimed to delineate the identity of Gli1+ cells and their contribution to wound healing in liver. ...
Haemodynamic alterations associated with hepatic vascular malformations in hereditary haemorrhagic telangiectasia: a cohort study [0.03%]
Pernille Darre Haahr,Mikael Kjær Poulsen,Jens Kjeldsen et al.
Pernille Darre Haahr et al.
Background & aims: Hereditary haemorrhagic telangiectasia (HHT) is a rare autosomal dominant disorder frequently associated with hepatic vascular malformations (HVMs). Up to 78% of patients develop HVMs, which may lead to...
Seohui Jang,Jihun Song,Eun Seok Kang et al.
Seohui Jang et al.
Background & aims: Changes in the amount of alcohol consumption among individuals with steatotic liver disease (SLD) result in shifts between the phenotypes of metabolic dysfunction-associated SLD (MASLD), MASLD with incr...
Molecular evolution of mosaic chromosome 18 copy-number alterations from gametes to hepatoblastoma [0.03%]
Elise Cendres,Marianna Cornet,Zoé Gautier et al.
Elise Cendres et al.
Background & aims: Constitutive chromosomal abnormalities often underlie developmental defects, while somatic copy-number alterations are recurrent events in cancers. Although these processes are usually studied separatel...
Severe Hepatitis Flares After Antiviral Withdrawal in Chronic Hepatitis B With Lymphoma: Impact of Rituximab [0.03%]
Yen-Chun Liu,Yu-Jia Shih,Chao-Wei Hsu et al.
Yen-Chun Liu et al.
Background & aims: Rituximab-containing chemotherapy predisposes chronic hepatitis B (CHB) patients to severe hepatitis B virus (HBV) reactivation, but the clinical outcomes after prophylactic nucleos(t)ide analogue (Nuc)...
Mengqi Chen,Heming Wang,Yicheng Zhao et al.
Mengqi Chen et al.
Background and aims: The shortage of liver donors represents a critical challenge for the treatment of end-stage liver failure. Previous studies explored ectopic hepatocyte organoid or spheroid transplantation for support...
Persistent Loss of Intrahepatic IFN-γ in HBV Is Linked to Selective Impairment of Liver-Resident CXCR6+NK Cells Despite Long-Term NUC Therapy [0.03%]
Boris J B Beudeker,Diren Arda Karaoglu,Shirin Nkongolo et al.
Boris J B Beudeker et al.
Background and aims: Chronic hepatitis B virus (HBV) infection remains incurable in most patients despite long-term nucleos(t)ide analogue (NUC) therapy. Interferon-γ (IFN-γ) is a cornerstone of antiviral immunity, but ...
Intrahepatic T cell analysis reveals Th17 and MAIT17 enrichment in primary sclerosing cholangitis [0.03%]
Lisa R V Brynjulfsen,Hesham ElAbd,Jonas Øgaard et al.
Lisa R V Brynjulfsen et al.
Background and aims: Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease where the exact contribution of T cells is unclear. To deeply characterize intrahepatic T cells in PSC, we combined single-cell...
Fatigue, depression, and impaired health-related quality of life in patients with vascular liver diseases: a multicentric European study☆ [0.03%]
Clémence Ramier,Virginia Hernandez-Gea,Laure Elkrief et al.
Clémence Ramier et al.
Background & aims: Patient-reported outcomes (PROs) are scarce in vascular liver diseases (VLD), including portal vein thrombosis (PVT) and Budd-Chiari syndrome (BCS). This study aimed to assess health-related quality of ...