Nikita Jhaveri,Bhagwati Gupta
Nikita Jhaveri
The nematode C. briggsae is an excellent genetic model for comparative and evolutionary studies involving its well-known cousin C. elegans . The vulval system in these two species has been used extensively to investigate genes and pathways ...
Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants [0.03%]
生成tdp-1无效等位基因及含有人类疾病变异体的TARDBP的人类化秀丽隐杆线虫模型
Jeremy Lins,Trisha J Brock,Chris E Hopkins et al.
Jeremy Lins et al.
Clinical variants of TARDBP are associated with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and other degenerative diseases. The predicted C. elegans ortholog of TARDBP is encoded by tdp-1 , but functional orthology h...
Precise mapping of one classic and three novel GluRIIA mutants in Drosophila melanogaster [0.03%]
果蝇GluRIIA经典突变体及三种新型突变体的精细定位
Bhagaban Mallik,Douglas J Brusich,Georgette Heyrman et al.
Bhagaban Mallik et al.
Mutation of the Drosophila melanogaster GluRIIA gene or pharmacological agents targeting it are commonly used to assess homeostatic synaptic function at the larval neuromuscular junction (NMJ). The commonly used mutation, GluRIIA SP16 , is ...
Experimental evolution of Saccharomyces uvarum at high temperature yields elevation of maximal growth temperature and loss of the mitochondrial genome [0.03%]
高温下毕赤酵母的实验进化使其最适生长温度升高并丢失了线粒体基因组
Emery R Longan,Justin C Fay
Emery R Longan
An organism's upper thermal tolerance is a major driver of its ecology and is a complex, polygenic trait. Given the wide variance in this critical phenotype across the tree of life, it is quite striking that this trait has not proven very e...
Azusa Yugeta,Hiroki Arai,Daiki Takahashi et al.
Azusa Yugeta et al.
Intercellular cleaning via autophagy is crucial for maintaining cellular homeostasis, and impaired autophagy has been associated with the accumulation of protein aggregates that can contribute to neurological diseases. Specifically, the los...
Nicotinamide riboside functions during development while beta-hydroxybutyrate functions during adulthood to extend C. elegans lifespan [0.03%]
烟酰胺核糖在发育过程中发挥作用，而β-羟基丁酸在成年期发挥作用以延长秀丽隐杆线虫的寿命
J Dylan Peters,McKenzie P Peters,Patrick C Bradshaw
J Dylan Peters
Nicotinamide riboside (NR), a form of vitamin B3 and a nicotinamide adenine dinucleotide (NAD + ) precursor, has been shown to activate the mitochondrial unfolded protein response (UPR mt ) and extend the lifespan when supplemented to C. el...
Molecular basis of essential and morphological variations across 12 balancer strains in C. elegans [0.03%]
秀丽隐杆线虫12个Balancer品系中必需基因和形态学变异的分子基础
Filip Cotra,Tatiana Maroilley,Maja Tarailo-Graovac
Filip Cotra
Balancers are primarily chromosomal rearrangements that allow lethal or sterile mutations to be stably maintained as heterozygotes. Strains with balanced lethal/sterile mutations are available at the Caenorhabditis Genetics Center. Such str...
Characterization of the role of Ume6 C-terminal tail in C. albicans morphological plasticity [0.03%]
芽丝型芽囊原虫形态可塑性中Ume6羧基端尾巴的作用机制表征
Ben Evans,Evan Spell,Douglas Bernstein
Ben Evans
C. albicans is an important human fungal pathogen and filamentation is essential for its virulence. Ume6 is a transcription factor critical for filamentation. Ume6 is composed of three domains, a long N terminal domain, Zn-finger domain, an...
IgG antibodies label the spermatozoan centriole of Drosophila melanogaster [0.03%]
IgG抗体标记果蝇精细胞中心体蛋白质成分
Ankit Jaiswal,Tomer Avidor-Reiss
Ankit Jaiswal
Centrioles are microtubule-based, barrel-shaped, subcellular organelles with evolutionarily conserved composition, structure, and function. Yet, in sperm cells, centrioles are remodeled, gaining species-specific composition and structure. T...
C. albicans UME7 deletion does not have major impacts on white opaque switching, filamentation, or virulence [0.03%]
UME7基因缺失对白光转换、丝状生长和毒力没有重大影响
Ben Evans,Evan Spell,Douglas Bernstein
Ben Evans
C. albicans is the most prevalent human fungal pathogen, and can be especially dangerous to immunocompromised individuals. One key aspect of C. albicans virulence is morphological plasticity. C. albicans can undergo a number of distinct mor...