Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants
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Clinical variants of TARDBP are associated with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and other degenerative diseases. The predicted C. elegans ortholog of TARDBP is encoded by tdp-1 , but functional orthology has not been demonstr... ...
