Samuel H Wu,Anna Amine,Kaya Ben-Efraim et al.
Samuel H Wu et al.
Plants synthesize compounds that modulate animal nervous systems through various mechanisms, but the key interactions remain understudied. We used chemotaxis assays with the nematode Caenorhabditis elegans to test if plant extracts can be d...
Cole R Jirsa,Bethany M Wise,Kaylia Edwards et al.
Cole R Jirsa et al.
Kremtemulon is a siphovirus isolated on the host bacterium Mycobacterium smegmatis mc 2 155 with a genome spanning 51,438 bp in length. Kremtemulon encodes 87 putative genes, 36 of which have predicted functions, and based on gene content, ...
Carla Martinez-Morant,Jui-Tung Liu,Yu-Lin Jiang et al.
Carla Martinez-Morant et al.
We previously reported that triazine thiols reduce apolipoprotein B (ApoB) secretion from human iPSC-derived hepatocytes (HLCs) and from humanized mice. To determine whether these compounds affected hepatocyte mRNA levels, we performed bulk...
Steven Awad,Madeline Kenney,Jennifer Blake-Mahmud
Steven Awad
Polyploidy, or whole genome duplication, is common in land plants. Polyploidy causes new gene combinations and is thought to provide an advantage amid the rising temperature and unpredictable precipitation regimes expected under climate cha...
Activation of 5-HT1A autoreceptors causes actin depolymerization in Drosophila serotonergic neurons [0.03%]
Ava Kinser,Jessie K Rhodes,Douglas H Roossien
Ava Kinser
Serotonergic neurons extend long, highly branched axons throughout the brain during development and are responsible for the modulation of many behaviors. Because proper behavioral output is dependent on precise outgrowth and targeting of se...
glorund functions in the Drosophila intestine to regulate triglyceride storage and the expression of lipid transport protein genes [0.03%]
Roman Voskoboynikov,Justin R DiAngelo
Roman Voskoboynikov
The intestine acts as the primary site for absorption of dietary lipids. These lipids are packaged and transported via lipoprotein complexes, whose altered levels correlate with metabolic disease. The Drosophila splicing factor glorund (gl...
Reduced expression of the electron transport chain component ATPsynβL in glutamate neurons changes Drosophila melanogaster sleep patterns through adulthood [0.03%]
Abigail Forrest,Maria Longenecker,Marciella V Shallomita et al.
Abigail Forrest et al.
A physiological marker of human aging is a decline in sleep patterns, a behavior also found in Drosophila melanogaster . To understand the connection between aging and sleep, we monitored sleep in long-lived flies. RNAi targeting the electr...
Hanan Brower,Sahar Mahmood,Joana Ruiz-Escobar et al.
Hanan Brower et al.
Cyanobacterial harmful algal blooms (cyanoHABs) can form in freshwater, and their toxins are harmful to flora and fauna, including humans. To assess the extent of cyanoHABs in urban waterways, seven creeks and Lady Bird Lake in Austin, TX U...
Stress-associated High Production of Large Extracellular Vesicles in the Parent Generation is Not Inherited by C. elegans F1 Progeny [0.03%]
压力相关的大量细胞外囊泡的产生不会在秀丽隐杆线虫亲本和其后代之间传递
Guoqiang Wang,Anna Joelle Smart,Jason F Cooper et al.
Guoqiang Wang et al.
Parental stress can influence stress responses in offspring. In C. elegans neurons, proteostress can induce the extrusion of aggregates and organelles in large extracellular vesicles called exophers. Under mild proteostress, ~20% of ALMR ...
The N-terminal α helix domain of the mitochondrial VDAC protein Por2 is dispensable for promoting the nuclear localization of yeast AMPK [0.03%]
线粒体电压依赖性阴离子通道蛋白Por2的N端α-螺旋结构域对于酿酒酵母AMPK核定位是非必需的
Kerry Brown,Hemanth Singuluri,Frank Perkins et al.
Kerry Brown et al.
In yeast, the mitochondrial voltage-dependent anion channel (VDAC) proteins Por1 and Por2 play regulatory roles in the regulation of Snf1, an ortholog of AMP-activated protein kinase (AMPK). An important question is whether Por1 and Por2 se...