Chemically Defined Non-human Glycans Comprising Galactose-α1-3-Galactose (α-Gal) Epitopes Glycoengineered into the Fragment Antigen-Binding (Fab) Domain of Cetuximab Differentially Affect Human Anti-α-Gal Immunoglobulin E (IgE) Binding [0.03%]
化学明确的非人糖链包含半乳糖-α1,3-半乳糖(α-半乳糖)表位，此类糖链被糖工程学改造进西妥昔单抗片段抗原结合（Fab）域，会影响人抗α-半乳糖免疫球蛋白E(IgE)的结合
Grayson Hatfield,Lioudmila Tepliakova,Roger Y Tam
Grayson Hatfield
Glycosylation of monoclonal antibodies (mAbs) critically affects their effector function, stability, pharmacokinetics, and immunogenicity. Glycan structures can vary with cell type and culture conditions and are often considered key critica...
Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension [0.03%]
巴索 drostat：用于难治性高血压的第一种皮质醇 aldosterone 合酶抑制剂
Imma Capriello,Alexander Dömling
Imma Capriello
Hypertension remains the world's leading preventable cause of cardiovascular morbidity and mortality. Despite the availability of diverse antihypertensive drug classes, resistant hypertension continues to affect millions globally, leading t...
Exploring Galectin‑3 as an Emerging Frontier in Biomarker Research for Clinical Trials Approaching Cardiovascular Diseases [0.03%]
探索胃泌素-3作为生物标志物研究的新兴前沿以期用于心血管疾病临床试验
Luís Perpétuo
Luís Perpétuo
Research has consistently highlighted galectin-3 (Gal-3) as a leading biomarker candidate for cardiovascular and cerebrovascular disease. Within studies focused on atherosclerosis-related cardiovascular disease, Gal-3 has played a multiface...
Cold Atmospheric Plasma in Biomedicine and Pharmacology: Multidisciplinary Perspectives on Therapeutic Applications [0.03%]
冷等离子体在生物医学和药理学中的应用：治疗应用的多学科视角
Punam Talukdar,Reetesh Borpatra Gohain,Subir Biswas et al.
Punam Talukdar et al.
Plasma medicine has emerged as a rapidly emerging interdisciplinary area of research that investigates the interaction of cold atmospheric plasma (CAP) with biological systems. The therapeutic power of CAP relies on the controlled generatio...
Development of Cathepsin B‑Activatable Cell-Penetrating Peptides for Tumor Targeting [0.03%]
用于肿瘤靶向的Cathepsin B激活型细胞穿膜肽的研究与发展
Konstantin Kuhne,Lydia Strohbach,Christin Neuber et al.
Konstantin Kuhne et al.
Extracellular cathepsin B is a driver of tumor progression and metastasis, and its potential as a diagnostic and prognostic marker is increasingly recognized. To harness its activity for triggering the uptake of activatable cell-penetrating...
A Simple and Robust Microfluidic Glomerular Filtration Barrier-on-a-Chip Platform for Investigating Drug-Induced Nephrotoxicity [0.03%]
一种简单且稳健的微流控芯片平台，可在药物引起的肾毒性研究中模拟足细胞滑膜屏障功能
Yeo Jin Hwang,Chaewon Jin,Hongsoo Choi et al.
Yeo Jin Hwang et al.
The glomerulus is the filtering unit of the kidney, and the glomerular filtration barrier (GFB) is responsible for filtering waste, retaining plasma protein, and maintaining fluid balance. Drug-induced nephrotoxicity is characterized by dys...
T‑Cell Immunoreceptor with Ig and Immunoreceptor Tyrosine-Based Inhibitory Motif Domains/Cluster of Differentiation 40 Cellular Nanovesicles Carrying Oxaliplatin Exhibited Superior Pancreatic Cancer Cells Therapy [0.03%]
含有Ig和基于酪氨酸的免疫受体抑制基序域的T细胞免疫受体/分化抗原簇40细胞纳米囊泡携带奥沙利铂对胰腺癌细胞治疗效果更佳
Wenlong Chen,Zining Zhang,Chuangchuang Zhao et al.
Wenlong Chen et al.
Profound chemoresistance and a highly immunosuppressive tumor microenvironment (TME) contribute to the high mortality rate of pancreatic ductal adenocarcinoma (PDAC). The overexpression of CD155 in PDAC facilitates its binding to the inhibi...
Copper Transporter 1‑Mediated Deregulation of Copper Homeostasis Impacts MYC and Oxidative Phosphorylation Pathways and Increases the Sensitivity of Tumor Cells to Complex I Inhibitors [0.03%]
铜转运蛋白1介导的铜稳态失调影响MYC和氧化磷酸化途径并增加肿瘤细胞对复杂I抑制剂的敏感性
Rima Mouawad,Nada H Eisa,Andrii Balia et al.
Rima Mouawad et al.
Certain tumors are dependent on copper for proliferation, metastasis, and energy production, making them particularly susceptible to copper depletion. Altering copper homeostasis has emerged as a promising strategy for treating these cancer...
l‑Boronophenylalanine (l-BPA) Dipeptide Prodrugs Enhance Boron Delivery to Tumors, Facilitate Tumor Eradication and Induce Tumor Vaccine Effect in Mice Following Neutron Irradiation [0.03%]
L-硼苯丙氨酸（l-BPA）二肽前药可增强硼在肿瘤中的传递，提高中子照射后小鼠的肿瘤消灭率并产生肿瘤疫苗效应
Michael Torgov,Arthur Raitano,Jason Cole Quintana et al.
Michael Torgov et al.
Boron neutron capture therapy (BNCT) is an emerging cancer treatment modality that has seen a resurgence due to its efficacy and the advent of compact neutron beam devices. BNCT is a binary cancer treatment that combines selective boron del...
Cathepsin B‑Responsive Phosphatidylinositol 3‑Kinase (PI3K) Prodrug for the Treatment of Pulmonary Fibrosis [0.03%]
用于治疗肺纤维化的半胱天冬酶B响应型磷脂酰肌醇3-激酶前药
Xiaomei Li,Tao Yang,Shuyue Lei et al.
Xiaomei Li et al.
PI3K inhibitors are effective therapeutic agents for pulmonary fibrosis, but they are plagued by systemic toxicity and a narrow therapeutic window. To overcome this limitation, we developed a novel enzyme-responsive prodrug delivery system ...