Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth [0.03%]
恩格列净的基于生理的药代动力学模型在青少年中的精准给药研究
Gabriela Pereira Milhm,Fernanda de Lima Moreira,Bárbara de Azevedo Abrahim-Vieira
Gabriela Pereira Milhm
Type 2 diabetes mellitus (T2DM) is a multifactorial disease that affects both adults and children. Treating T2DM in children poses a challenge because of the difficulties in conducting clinical trials in this special population. Empaglifloz...
A New Nitroimidazole-Based Drug Attenuates Skeletal Myositis and Overcomes Benznidazole Resistance in Experimental Chagas Disease [0.03%]
一种新型硝基咪唑类药物可改善骨骼肌炎和克服实验室查加斯病的苯硝唑耐药性
Graziela Domingues De Almeida Lima,Elda Gonçalves-Santos,Monique Dias Benedetti et al.
Graziela Domingues De Almeida Lima et al.
Skeletal myositis is a disabling complication of Chagas disease for which the first-choice antiparasitic chemotherapy has limited efficacy. Therefore, we synthesized and investigated the potential of the novel nitroimidazole-based drug 1-(2...
Antimicrobial Systems Based on Essential Oils Advanced by Zinc Oxide Nanoparticles [0.03%]
基于氧化锌纳米粒子的精油抗菌系统的发展
Greta Kaspute,Urte Prentice,Roman Viter et al.
Greta Kaspute et al.
Zinc oxide nanoparticles (ZnO NPs) have emerged as a promising material to enhance the performance of essential oils (EOs) in various applications due to their unique properties, including chemical stability, biocompatibility, and antimicro...
Interaction between Paracetamol Glucuronide and a Glucose-Sensitive Insulin Molecule (NNC2215): Increased Risk of Hypoglycemia [0.03%]
对乙酰氨基酚葡糖苷酸与葡萄糖敏感型胰岛素分子(NNC2215)的相互作用增加低血糖风险
Jeppe Sturis,Lene Alifrangis,Peter K Nielsen et al.
Jeppe Sturis et al.
NNC2215 is an insulin analog with glucose-sensitive properties on activation of the insulin receptor. In NNC2215, a glucoside and a macrocycle with strong affinity to glucose were conjugated to insulin. This introduced a switch that is open...
Kidney-Targeted Nanoparticle Delivery of Formoterol Mitigates Diabetic Kidney Disease without Adverse Cardiac Effects [0.03%]
纳米颗粒靶向递送福莫特罗可减轻糖尿病肾病而无不良心脏反应
Ernest L Vallorz,Kristan Cleveland,Natalie E Scholpa et al.
Ernest L Vallorz et al.
Mitochondrial dysfunction plays a critical role in the progression of diabetic kidney disease (DKD). Previous research indicates that the FDA-approved β2-adrenergic receptor agonist and bronchodilator formoterol are efficacious at restorin...
A Minimally Invasive, Subcutaneous Biosensor Reliably Estimates Plasma Methotrexate Exposure and Quantifies Plasma-to-Tissue Transport Kinetics [0.03%]
一种微创性皮下生物传感器可可靠估算血浆氨甲蝶呤暴露量并测量血浆向组织运输动力学
Jennifer M Gibson,Zeki Duman,Nicole A Emmons et al.
Jennifer M Gibson et al.
Electrochemical aptamer-based (EAB) sensors enable high-frequency, real-time measurements of drug concentrations in situ in the body, offering a potential means of rendering therapeutic drug monitoring (TDM) as convenient, timely, and preci...
Phosphatidylinositol-3-kinase/Protein Kinase B (PI3K/AKT) and Nucleotide-Binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 (NLRP3) Inflammasome Modulation Underlies the Neuroprotective Effects of Vildagliptin in a Rotenone-Induced Mouse Model of Parkinson's Disease [0.03%]
磷酸肌醇-3-激酶/蛋白激酶B(PI3K/AKT)和核苷酸结合寡聚化域样受体家族 pryin结构结构域含3蛋白(NLRP3)炎性小体的调节作用是维达agliptin在罗tenone诱导的小鼠帕金森病模型中发挥神经保护作用的基础
Dishank Patel,Ritu Soni,Inderjeet Bhogal et al.
Dishank Patel et al.
Parkinson's disease (PD) is a chronic neurodegenerative disorder marked by the gradual loss of dopaminergic neurons. Mitochondrial impairment, neuroinflammation, oxidative stress, and abnormal aggregation of α-synuclein are the most promin...
A Novel Nitric Oxide Donor Induced Ferroptosis in Drug-Resistant Ovarian Cancer Cells through Lysosomal Iron Metabolism Regulation and Lipid Peroxidation [0.03%]
一种新型一氧化氮供体通过溶酶体铁代谢调控和脂质过氧化诱导耐药卵巢癌细胞发生铁死亡的研究
Jiachen Weng,Fan Cao,Xiufan Wu et al.
Jiachen Weng et al.
Ovarian cancer exhibits the highest mortality rate among all gynecologic malignancies. A major obstacle in its clinical management is the development of chemoresistance. Consequently, there is an urgent and unmet need to develop novel thera...
Exosomal microRNAs in Periodontitis: From Molecular Footprints to Clinical Frontiers [0.03%]
牙周炎中的外泌体微小RNA：从分子特征到临床应用
Maaz Anwer Memon,Danial Qasim Butt,Noriko Mizusawa et al.
Maaz Anwer Memon et al.
Periodontitis is a widespread chronic inflammatory disease driven by host-microbial interactions and immune dysregulation, often resulting in alveolar bone loss and systemic complications. Exosomes, small extracellular vesicles enriched wit...
Engineering the Host Defense Peptide from Scorpion Venom for Safer and More Potent Antibreast Cancer Activity [0.03%]
工程化改造来源于蝎毒的宿主防御肽以获得更强和更安全的抗乳腺癌活性
Cyntia Silva Oliveira,Laertty Garcia Sousa Cabral,Rosely Cabette Barbosa Alves et al.
Cyntia Silva Oliveira et al.
Host Defense Peptides (HDPs) are key components of the innate immune system and promising candidates for anticancer therapy due to their ability to interact with cell membranes. In this study, we investigated the structure-activity relation...