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Interaction between Paracetamol Glucuronide and a Glucose-Sensitive Insulin Molecule (NNC2215): Increased Risk of Hypoglycemia

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NNC2215 is an insulin analog with glucose-sensitive properties on activation of the insulin receptor. In NNC2215, a glucoside and a macrocycle with strong affinity to glucose were conjugated to insulin. This introduced a switch that is open (activated) or clos... ...