From In Silico to Clinic: Harnessing Noncoding RNAs for Diabetes Research and Therapy, a Step toward ncRNA Precision [0.03%]
从计算机模拟到临床应用：利用非编码RNA进行糖尿病研究和治疗，迈向非编码 RNA 精准医疗的一小步
Nadia M Hamdy,Sherien M El-Daly,Ola Elazazy et al.
Nadia M Hamdy et al.
Diabetes mellitus (DM) represents a heterogeneous group of metabolic disorders characterized by chronic hyperglycemia and progressive metabolic dysregulation, arising from distinct but overlapping pathogenic mechanisms. Emerging evidence po...
Exploring the Impact of Multiple Gene Mutations on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Response in Asian Nonsmall Cell Lung Cancer Patients [0.03%]
探讨多基因突变对亚洲非小细胞肺癌表皮生长因子受体酪氨酸激酶抑制剂疗效影响的研究
Rui Jing,Yandong Miao,Ummi Nadira Daut et al.
Rui Jing et al.
Nonsmall cell lung cancer (NSCLC) is characterized by diverse genetic alterations, among which epidermal growth factor receptor (EGFR) mutations are the most common, particularly in adenocarcinoma, occurring in 10-15% of patients. However, ...
Linking biochemical and cellular efficacy of MERS coronavirus main protease inhibitors [0.03%]
MERS冠状病毒主要蛋白酶抑制剂的生化和细胞疗效关联研究
Van N T La,Noa Lahav,Moshe Goldsmith et al.
Van N T La et al.
Compounds that bind to the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) main protease (MPro) often produce biphasic concentration-response curves (CRCs) in biochemical assays; low concentrations activate the enzyme and high conce...
Inhibition of Lin-11, Isl-1, and Mec‑3 Kinase (LIMK) Activity Attenuates Astrogliosis and Vascular Remodeling in an Experimental Model of Cuprizone-Induced Demyelination in Mice [0.03%]
抑制Lin-11、Isl-1和Mec-3激酶(LIMK)活性可减轻小鼠杯rizone诱导的脱髓鞘实验模型中的星形胶质细胞增生和血管重塑作用
Abhishek Roy,Shradha Pendbhaje,Divya Goyal et al.
Abhishek Roy et al.
A variety of neurological impairments are caused by the loss of myelin, which is a hallmark of demyelinating diseases such as multiple sclerosis (MS). The cuprizone model is a well-established demyelination model in which specific brain reg...
Cyclin-Dependent Kinases 4 and 6 Inhibitors: An Emerging Therapeutic Framework from Growth Suppression to Tumor Clearance [0.03%]
细胞周期素依赖性激酶4和6抑制剂：从抑生长到抗肿瘤的新兴治疗框架
Cong Ma,Xuan Ji,Wenqin Huang et al.
Cong Ma et al.
This review explores strategies to overcome the clinical limitations of Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors, namely, reversible cytostasis and acquired resistance. We outline an emerging therapeutic framework in which these...
Sertraline Enhances Bacterial Control without Adversely Affecting the Pharmacodynamic-Pharmacokinetic Properties of Frontline Tuberculosis Drugs [0.03%]
塞瑞替尼增强细菌控制作用且不会影响一线结核病药物的药动学和药效学性质
Kanika Bisht,Monica Yadav,Mahima Madan et al.
Kanika Bisht et al.
Host-directed therapies (HDTs) are gaining importance as innovative intervention strategies for shortening the treatment durations of tuberculosis (TB), a major public health burden. The combination of TB drugs and sertraline (SRT), an FDA-...
Repurposing FDA-Approved Drugs as Potential Inhibitors of Feline Infectious Peritonitis Virus 3CLpro: An Integrated In Silico and In Vitro Study with Synergistic Combination Analysis [0.03%]
一种体外和基于计算机的体内实验相结合研究：将美国食品药品监督管理局已批准的药物重新配制为猫传染性腹膜炎病毒3CLpro潜在抑制剂及其协同组合分析
Varanya Lueangaramkul,Natjira Mana,Nattarat Thangthamniyom et al.
Varanya Lueangaramkul et al.
Feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV) remains a critical therapeutic challenge with no universally approved treatments. We employed a drug repurposing strategy targeting the viral main protease (3CLpro), e...
Overcoming Pharmacokinetic and Peripheral Safety Challenges in Psychedelic Therapies: The Promise of Advanced Drug Delivery Systems [0.03%]
应对迷幻疗法中的药代动力学和外周安全挑战：先进药物输送系统的前景
Tianshu Zhang,Cong Lin,Xiaohui Wang
Tianshu Zhang
Classic serotonergic psychedelics-such as lysergic acid diethylamide (LSD), psilocybin, and N,N-dimethyltryptamine (DMT)-hold remarkable promise for treating neuropsychiatric disorders, yet their clinical translation is severely constrained...
Head-to-Head Comparison of Monomeric, Homodimeric, and Heterodimeric Fibroblast Activation Protein-Targeting Radioligands Based on Small Molecule Inhibitor and Cyclic Peptide [0.03%]
基于小分子抑制剂和环肽的成纤维细胞活化蛋白靶向放射配体的头对头比较（单聚体、同二聚体和异二聚体）
Kosuke Saito,Hiroyuki Watanabe,Kazuma Nakashima et al.
Kosuke Saito et al.
Fibroblast activation protein (FAP) has been identified as a promising biomarker for tumor-targeting radioligands. Among these, a small molecule FAP inhibitor (FAPI), [68Ga]-Ga-FAPI-46, and a cyclic peptide-based FAP-targeting radioligand, ...
Cell-Penetrating Peptide-Mediated Modulation of Endoplasmic Reticulum Stress: A Bioengineered and Translational Approach [0.03%]
细胞穿透肽介导的内质网应激调节：生物工程与转化医学方法
Tripti Paliwal,Radhika Joshi,Sarvesh Paliwal et al.
Tripti Paliwal et al.
Endoplasmic reticulum (ER) stress is central to the onset and progression of metabolic and inflammatory disorders, such as insulin resistance, hepatic steatosis, and cardiovascular dysfunction. The unfolded protein response, triggered by ER...