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Head-to-Head Comparison of Monomeric, Homodimeric, and Heterodimeric Fibroblast Activation Protein-Targeting Radioligands Based on Small Molecule Inhibitor and Cyclic Peptide

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Fibroblast activation protein (FAP) has been identified as a promising biomarker for tumor-targeting radioligands. Among these, a small molecule FAP inhibitor (FAPI), [68Ga]-Ga-FAPI-46, and a cyclic peptide-based FAP-targeting radioligand, [177Lu]-Lu-FAP-2286,... ...