Millena de S Afonso,Pamella M de Souza,Adriany L Dos Santos et al.
Millena de S Afonso et al.
Sun protection has become a significant public health issue in recent decades due to the high incidence of skin diseases related to excessive exposure to ultraviolet (UV) rays. The use of nanosystems in sunscreens represents a promising inn...
Schisandrin B Upregulates Sirtuin 3 and Mitigates Lung Epithelial Injury Induced by Nickel Nanoparticles [0.03%]
Bo Zhang,Yue-Chen Xing,Ge-Ge Tang et al.
Bo Zhang et al.
NiNPs pose a persistent occupational hazard to the lung. However, it remains unclear whether mitochondrial lipid metabolismcentered on mitochondrial deacetylase Sirt3can be mechanistically modulated to mitigate NiNPs-induced epithelial ...
Identification of Acoramidis as a Repurposed Inhibitor of the DNA Sanitization Enzyme MutT Homologue 1 [0.03%]
Takeshi Yokoyama,Teruya Nakamura,Masataka Goto et al.
Takeshi Yokoyama et al.
Cancer cells experience elevated oxidative stress and rely on MutT Homologue 1 (MTH1) to sanitize the oxidized nucleotide pool and prevent the incorporation of damaged nucleotides into DNA. This dependency has established MTH1 as a promisin...
Current and Future Applications of Three-Dimensional Brain and Cardiac Organoids in Translational Medicine: From Disease Modeling to Drug Discovery [0.03%]
Anchal Kaushik,Daby Thakur Prasad Mishra,Raghu Solanki et al.
Anchal Kaushik et al.
Over the past decade, organoid research has made transformative advances, emerging as a powerful platform to address key limitations of traditional biomedical models. Although animal systems remain indispensable for studying disease mechani...
A Novel Tumor-Targeting Drug-Delivery System of Docetaxel-Loaded Poly(β-hydroxybutyrate) Nanoparticles Binding with a Specific Lectin: Design, Preparation, and Evaluation [0.03%]
Wen-Feng Dong,Fei Li,Juan Bi et al.
Wen-Feng Dong et al.
Tumor cells maintain rapid proliferation based on their highly increasing energy metabolism. Therefore, glucose-related energy substrate control therapy may become a promising approach for cancer treatment. Based on the specific binding cap...
Linda Schäker-Hübner,Finn K Hansen
Linda Schäker-Hübner
The development of selective histone deacetylase inhibitors (HDACi) and thus the identification of suitable chemical probes is still highly complex. Moreover, in the past, the results of oversimplified biochemical HDAC assays have often bee...
Structure-Activity Relationship Studies Enable Optimization of a Small-Molecule Autophagy Activator and Evaluation of Effects on Cell Death Pathways [0.03%]
Andrew Dobria,Andrea Arrieche Suarez,Thomas Whitmarsh-Everiss et al.
Andrew Dobria et al.
Autophagy is a catabolic cellular process that degrades and recycles cellular components. Dysregulation of autophagy can contribute to the development and progression of many different diseases, including cancer and neurodegenerative diseas...
Mireia Toledano-Pinedo,Isabel Iriepa,M Mercedes Rodríguez-Fernández et al.
Mireia Toledano-Pinedo et al.
Masupirdine is an oral, small, and safe molecule, readily available by a robust, two-step synthetic scheme, showing a potent, selective serotonin 5-HT6 receptor antagonist profile, pro-cognitive effects in various behavioral animal models i...
Small Interfering Ribonucleic Acid (siRNA)-Based Therapeutics in Inflammatory Bowel Disease: Crosstalk between Immune Modulation and Epithelial Barrier Restoration [0.03%]
Mansi Patel,Bhagyabhumi Shah
Mansi Patel
Inflammatory bowel disease is an autoimmune disorder associated with the gastrointestinal tract that includes ulcerative colitis and Crohn's disease, aggravated by dysregulated immune responses, disrupted epithelial barriers, and microbial ...
Ionic Liquid Pilocarpine Serves as Therapeutic Cosolvent and Permeation Enhancer for Glaucoma Medication [0.03%]
Ashish Trital,Lei Xu,Burhan Ates et al.
Ashish Trital et al.
The efficacy of hydrophobic ocular drugs is significantly hindered by their low bioavailability, for which poor water solubility is a major contributing factor. In this work, we synthesized pilocarpine-derived ionic liquid [Pilo-OEG] Cl (PO...