Marine-Derived Polyketides from Penicillium sp. Enhance Cutaneous Wound Healing through Metabolic and Regenerative Signaling [0.03%]
海洋泛菌属真菌衍生的聚酮类化合物通过代谢和再生信号促进皮肤伤口愈合
Mücahit Varlı,Eun-Young Lee,Qian Gao et al.
Mücahit Varlı et al.
Marine-derived fungi represent a rich yet underexplored source of bioactive secondary metabolites with therapeutic potential. In this study, we isolated and characterized five polyketide compounds from the marine-derived fungus Penicillium ...
IMMUNIA: A Reasoning-Centered Framework for Immunoregulatory Surfaceome Discovery [0.03%]
IMMUNIA：一种基于推理的免疫调节表面组发现框架
Namu Park,Jung Hyun Lee
Namu Park
Biomarker discovery in immunotherapy remains limited by approaches that rely primarily on correlation-based analyses, which often fail to capture the context-dependent and mechanistic nature of tumor immune interactions. Here, we present IM...
Green Tea Catechin Metabolite 5‑(3',5'-Dihydroxyphenyl)-γ-valerolactone Enhances the Antitumor Efficacy of Immune Checkpoint Blockade by Priming Type‑1 Immunity [0.03%]
表没食子儿茶素代谢产物5-(3',5'-二羟基苯基)-γ-=valerolactone通过促进1型免疫活化增强免疫检查点阻断的抗肿瘤功效
Yilin Zhang,Reno Kawamoto,Motofumi Kumazoe et al.
Yilin Zhang et al.
Cancer immunotherapy has achieved remarkable clinical success; however, its efficacy remains limited in many patients due to insufficient activation of antitumor immune responses. Green tea catechins are known to exert various biological ac...
Activation of the Aryl Hydrocarbon Receptor-Cytochrome P450 1A1 Axis Mediates the Selective Cytotoxicity of 2‑Phenyl-Imidazo[1,2‑ a]Pyridine Derivatives in Triple-Negative Breast Cancer Cells [0.03%]
芳烃受体-细胞色素P450 1A1轴的激活介导了2-苯基-咪唑并[1,2-a]吡啶衍生物在三阴性乳腺癌细胞中的选择性细胞毒性作用
Lo-Wei Lin,Carley E Beeman,Jun Yang et al.
Lo-Wei Lin et al.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with poor clinical outcomes and limited treatment options. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates ...
Recent Developments in the Diagnosis and Treatment of Disseminated and Rare Melanoma with Radiotheranostics [0.03%]
近年来放疗诊断学在黑色素瘤分散及少见病例中的新发展
Rüdiger M Exner,Jason S Lewis,Lisa Bodei et al.
Rüdiger M Exner et al.
Disseminated melanoma, particularly of rare subtypes such as mucosal or uveal melanoma, is a difficult to treat, deadly disease characterized by poor median survival and resistance to a wide range of treatments. Despite new approvals, such ...
Pharmacokinetics, Target Engagement of an Immunoproteasome Subunit Low-Molecular-Mass Polypeptide‑2 (LMP2) Inhibitor AR-01, and Its Anti-Alzheimer's Effects in Rodents [0.03%]
AR-01的药代动力学、靶点 engagement 及其在啮齿类动物中的抗阿尔茨海默病作用及对低分子量多肽-2(LMP2)免疫蛋白酶体亚单位的影响
Til Bahadur Thapa Magar,Minsu Kim,Yoonha Kim et al.
Til Bahadur Thapa Magar et al.
Previously, we reported that AR-01, an irreversible macrocyclic peptide epoxyketone, selectively inhibits the immunoproteasome catalytic subunit LMP2 (low-molecular mass polypeptide-2). We also showed that LMP2 inhibition produces anti-Alzh...
Selective Serotonin-1A Receptor Activation Elicits Antinociceptive Activity in the Knee Osteoarthritis and Plantar Incisional Postoperative Pain Models in Rats [0.03%]
选择性5-羟色胺受体激动在膝骨关节炎和术后切口痛模型中发挥镇痛作用
Ronan Depoortère,Adrian Newman-Tancredi
Ronan Depoortère
NLX-204 is a high selectivity/high efficacy agonist at serotonin 5-HT1A receptors, which are well-established modulators of pain processing. Here, we evaluated the analgesic activity of NLX-204 in two rat models of nociceptive/inflammatory ...
Identifying Antibiotic Effects of Investigational Drugs on Commensal Bacteria with Machine Learning [0.03%]
利用机器学习识别 investigational drugs 对共生细菌的抗生素效应
Hrshita Gowda,Wenbo Lu,Paul Skaluba et al.
Hrshita Gowda et al.
Many human-targeted medications have been found to impact patients' gastrointestinal microbiomes, which has been proposed as an unrecognized source of drug side effects, comorbidities, and reduced treatment efficiencies. However, current me...
A Simple and Cost-Effective Electrochemical Assay for Heart Failure Prognosis Using Soluble Suppression of Tumorigenicity 2‑Specific Nanobodies [0.03%]
一种简单且低成本的电化学测定法用于心力衰竭预后检测，使用可溶性抑癌基因特异性纳米抗体检测
Suwitchaya Sirimanakul,Joseph D Hurley,Nakarin Vutipow et al.
Suwitchaya Sirimanakul et al.
Heart failure (HF) is a major global health concern, particularly in low- and middle-income countries where it is often underdiagnosed. Prognostic testing plays a crucial role in guiding treatment and monitoring disease progression. In this...
Heparanase, Endothelial Dysfunction, and Cardiovascular Risk: The Emerging Role of Vitamin D [0.03%]
硫酸乙酰肝素蛋白聚糖内切糖苷酶、血管功能障碍与心血管风险：维生素D的潜在作用
Apurva Chittoda,Nikhil Narwaria,Geena Varghese et al.
Apurva Chittoda et al.
Endothelial dysfunction is a central pathophysiological mechanism in the development of cardiovascular disease (CVD), the leading global cause of morbidity and mortality. Vascular homeostasis critically depends on the endothelial glycocalyx...