The Protean Nature of 14-3‑3 Proteins in G Protein-Coupled Receptor Signaling: Emphasizing Selectivity and Dynamic Interactions at the Neurokinin Receptor 3 Interface [0.03%]
G蛋白偶联受体信号转导中14-3-3蛋白的多面性：着重于神经激肽受体3界面上的选择性和动态相互作用
Manel Zeghal,Danylo Aloshyn,Samantha K Rogers et al.
Manel Zeghal et al.
Recent models of GPCR signaling extend beyond the canonical paradigm of ligand-induced activation primarily mediated by G-proteins and β-arrestins. Indeed, the various outcomes of GPCR activation are precisely regulated by several factors,...
Investigating the Anticancer Effects of Sulforaphane in an In Vitro Coculture Model of Prostate Cancer Cells with Engineered Heart Tissue [0.03%]
一种用前列腺癌细胞与工程化心肌组织共培养模型研究异硫氰酸酯抗肿瘤作用的体外方法
Jane In den Birken,Laura Rathjens,Hannah Münch et al.
Jane In den Birken et al.
Sulforaphane (SFN) is a phytoderived compound abundant in cruciferous plants that possesses a broad spectrum of anticancer properties. We showed that SFN-induced caspase-mediated apoptosis in grade IV bone metastasis-derived androgen-insens...
Molecular Repositioning of Celecoxib as a Neurotherapeutic Agent in Fragile X‑Associated Tremor/Ataxia Syndrome (FXTAS) [0.03%]
西乐葆分子重定位作为脆性X染色体综合征伴发震颤/共济失调综合症(FXTAS)的神经治疗药物
Soumalya Das,Aditi Pramod Kumari,Krishna Singh et al.
Soumalya Das et al.
Fragile X-associated tremor/ataxia syndrome (FXTAS), a nucleotide repeat expansion disorder, arises from CGG repeat expansions in the 5' untranslated region (UTR) of the fragile X messenger ribonucleoprotein 1 (FMR1) gene, leading to RNA fo...
Correction to "Sigma‑2 Receptor/Transmembrane Protein 97 in Pain Modulation: Tracing Historical Roots and Current Research Directions" [0.03%]
关于σ-2受体/跨膜蛋白97在疼痛调节中的作用：追溯历史根源和当前研究方向的更正
Veronica M Hong,Avaneesh Rade,Amulya Bhaskara et al.
Veronica M Hong et al.
[This corrects the article DOI: 10.1021/acsptsci.5c00157.]. © 2025 American Chemical Society.
Fibroblast Activation Protein Inhibitor (FAPI)-Radioligand PET/CT in the Assessment of Nononcological Diseases: A Narrative Review [0.03%]
纤维活化蛋白抑制剂（FAPI）放射配体PET/CT在非肿瘤性疾病评估中的作用：叙事综述
Forough Kalantari,Anton Amadeus Hörmann,Martha Pokarowski et al.
Forough Kalantari et al.
This narrative review provides an overview of benign FAPI-PET/CT or PET/MRI findings and studies investigating molecular imaging in nononcological diseases. Although the current focus of [68Ga]-Ga-FAPI PET/CT is on oncologic indications, th...
Discovering Potent and Diverse Agonists for the β2‑Adrenergic Receptor via Machine Learning [0.03%]
基于机器学习的β2-肾上腺素受体强效和多样 agonist 的发现
Siyao Zhang,Chenyang Wu,Shiyu Wang et al.
Siyao Zhang et al.
Screening diverse chemical structure compounds is an essential task in modern drug discovery. It provides different opportunities to avoid patent invasion, avoid potential toxicity observed in similar compounds, and execute new potential ph...
Asparaginase with Combined Mutations: Optimized Biochemistry and Lowered Allergic Risk [0.03%]
兼备多种突变的天冬酰胺酶：优化生化效应及降低过敏风险
Tales Costa-Silva,Grace V Ruiz-Lara,Iris Munhoz Costa et al.
Tales Costa-Silva et al.
Biotechnology and biomedical advances have driven the development of novel biopharmaceuticals to meet growing clinical demands. Among approved biologics, native Escherichia coli asparaginase has been under continuous optimization to improve...
Impact of Symptomatic Slow-Acting Drugs on Inflammatory Pathways in Osteoarthritis: Therapeutic Advances and Future Challenges [0.03%]
改善骨关节炎症状的慢作用药物对炎症通路的影响：治疗进展与未来挑战
Vitor Alfredo de Santana Silva,Katarine Gabriely Aurista do Nascimento,Priscila Gubert et al.
Vitor Alfredo de Santana Silva et al.
Osteoarthritis (OA) is a leading cause of physical disability, psychological distress, and a significant economic burden worldwide. Current treatments alleviate symptoms; however, disease progression remains largely uncontrolled, highlighti...
Ortho-Hydroxyanilides: Slow-Acting, Selective Histone Deacetylase 1/2 Inhibitors Suitable for Photocaging Applications [0.03%]
正式羟基苯胲类：组蛋白去乙酰化酶1/2选择性缓慢激活抑制剂适合光保护应用
Irina Honin,Tao Sun,Nisha Setia et al.
Irina Honin et al.
Histone deacetylases (HDACs) regulate gene expression and are promising targets in oncology. Especially the class I isoforms HDAC1 and HDAC2 are overexpressed in cancer. However, while ortho-aminoanilides with a suitable (het)-aryl substitu...
Anti-pyocyanin Antibody Exhibits Cytotoxicity Protective Effects on Macrophages: A Promising Innovative Therapeutic Approach for Pseudomonas aeruginosa Infections [0.03%]
抗吡咯烷多克隆抗体对巨噬细胞的细胞毒性保护作用：假单胞菌感染的新型潜在治疗方法
Bárbara Rodríguez-Urretavizcaya,Tamás Posvai,Lluïsa Vilaplana et al.
Bárbara Rodríguez-Urretavizcaya et al.
Pseudomonas aeruginosa is considered one of the most threatening pathogens worldwide, due to its high adaptability, which leads to resistance to classical antimicrobials. This fact has driven the development of new therapeutic strategies to...