Polyphenol Antioxidants Inhibit Peroxynitrite-Mediated DNA Damage In Vitro and in E. coli [0.03%]
多酚抗氧化剂抑制过氧亚硝酸盐介导的DNA损伤（体外及E.coli体内）
Hsiao C Wang,Nathan R Perron,Fatema Tuz Zohara et al.
Hsiao C Wang et al.
Peroxynitrite causes oxidative DNA damage that can lead to cancer, cardiovascular, and neurodegenerative diseases. Polyphenol compounds have been extensively studied for their ability to prevent oxidative stress and DNA damage, but the cell...
SCaN: A Screening and Characterization Platform for Nanosuspensions Enables In Vivo Delivery of a Crystalline hRpn13Pru Degrader [0.03%]
SCaN：一种纳米悬浮液筛选和表征平台，可实现结晶hRpn13Pru降解剂的体内递送
Christine S Brugger-Muli,Snehal M Gaikwad,Wendy du Bois et al.
Christine S Brugger-Muli et al.
Proteolysis-targeting chimeras (PROTACs) and degraders have been developed against the hRpn13 fragment hRpn13Pru that is present in various cancer types. Testing the performance of these hRpn13Pru-targeting compounds in pharmacokinetic and ...
Characterization of the Cross-Resistance of SARS-CoV‑2 Main Protease Inhibitors, Ibuzatrelvir, Ensitrelvir, and Nirmatrelvir [0.03%]
SARS-CoV-2 主蛋白酶抑制剂Ibuzatrelvir、Ensitrelvir和Nirmatrelvir交叉耐药表型的特征分析
Haozhou Tan,Xiang Chi,Xufang Deng et al.
Haozhou Tan et al.
The emergence of resistance to SARS-CoV-2 main protease (Mpro) inhibitors such as nirmatrelvir poses a significant threat to the long-term effectiveness of COVID-19 antivirals. Ibuzatrelvir (PF-07817883) and ensitrelvir are next-generation ...
Harnessing Anthocyanins to Mitigate Inflammation, Dysbiosis, and Aging in the Gastrointestinal Tract [0.03%]
利用花青素减轻肠道炎症、菌群失调和衰老
Livia Resende Lopes,Adriel Aparecido de Souza,Tanila Wood Dos Santos et al.
Livia Resende Lopes et al.
The gut microbiota are a dynamic ecosystem that is crucial for immune regulation and maintenance of intestinal barrier integrity. Dysbiosis within this community contributes to the chronic inflammation characteristic of inflammatory bowel d...
Advances in Pharmacological Treatments for Cystinosis: Cysteamine and Its Alternatives [0.03%]
胱氨酸贮积症的药物治疗进展： cysteamine及其替代品
Aitor Carneiro,D Heulyn Jones
Aitor Carneiro
Cystinosis is an inherited lysosomal storage disorder characterized by the intralysosomal accumulation of crystals of cystine. This alteration is caused by the absence of the lysosomal membrane transporter cystinosin, which leads to clinica...
Effect of Structural Alteration in Albumin Binder Moiety on Tumor Accumulation of Somatostatin Receptor 2‑Targeted Radioligands [0.03%]
结构重塑对肿瘤部位生长抑素受体2靶向配体摄取的影响研究
Takuma Yamane,Nobuki Kazuta,Kazuma Nakashima et al.
Takuma Yamane et al.
Somatostatin receptor 2 (SSTR2) is a valuable target for the treatment of patients with neuroendocrine tumors (NETs). [177Lu]-Lu-DOTA-TATE, an SSTR2-targeted ligand, is clinically used for therapy in patients with NETs; however, a low-absor...
Influence of Lipid Composition on Nonspecific Interactions of Serotonin with Model Membranes [0.03%]
脂质组成对五羟色胺与模型膜非特异性相互作用的影响
Jamie Gudyka,Jasmin Ceja Vega,Jessica Said et al.
Jamie Gudyka et al.
Serotonin is a monoamine neurotransmitter, which plays an important role in the development and functioning of the central nervous system. Recent biophysical studies reveal that nonspecific interactions between serotonin and lipid membranes...
Direct Injection Mass Spectrometry and iFishMass for the High-Throughput Analysis of Antibody Modifications [0.03%]
用于抗体修饰高通量分析的直接注入质谱和iFishMass技术
Jennifer Aguilan,Carlos Madrid-Aliste,Fereshteh Zandkarimi et al.
Jennifer Aguilan et al.
High-throughput analysis has become a critical component in chemical biology and analytical chemistry due to the large libraries of compounds that are screened every day for drug development. Mass spectrometry (MS)-based proteomics is the m...
3‑(4-Hydroxyphenyl-1,2,3-Triazol-1-yl)Quinuclidine, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, Attenuates Inflammatory Pain with a Favorable Central Nervous System Safety Profile in Mice [0.03%]
3-(4-羟基苯基-1,2,3-三唑-1-基)奎尼丁，一种选择性α7烟碱乙酰胆碱受体激动剂，可通过改善小鼠中枢神经系统安全性来减轻炎症痛
Thorsang Weerakul,Hasriadi,Krittamate Chatdamrongsakool et al.
Thorsang Weerakul et al.
Selective α7 nicotinic acetylcholine receptors (α7 nAChRs) have emerged as therapeutic targets for managing various pain conditions, including inflammatory pain. Activation of α7 nAChRs by selective agonists has been shown to exert both ...
A Microfibrous Extracellular Matrix Platform for In Vitro Hepatotoxicity Screening: A Next-Generation Model for Humanized Liver Research [0.03%]
一种微纤化细胞外基质平台：用于体外肝毒性筛选的人工肝脏研究下一代模型
Navneet Kaur,Mary Jean Savitsky,Michael Lipscomb et al.
Navneet Kaur et al.
Drug-induced hepatotoxicity is a significant concern in drug development and patient safety. The liver, responsible for drug metabolism, can suffer from damage caused by certain medications, leading to inflammation, cellular damage, and eve...